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Recent News and Articles on the Keywords: protection against + gut against + mucins  Related to the article below (Last Update: 5/12/2008)

DNC: McCain on the Environment: Different Issue, Same Double Talk
Biloxi Sun Herald,  USA -
... sweetheart deals, appointing radical right wing judges who would gut environmental regulations, and voting against key environmental protection efforts. ...
Credit-Default Swaps: Weapons of Mass Speculation
Barron's - May 11, 2008
The buyers of CDS typically are hedgers seeking to protect against the risk of untoward widening in the credit spreads on their holdings, or speculators ...
McCain Breaks with Bush on Climate
Washington Post, United States -
... sweetheart deals, appointing radical right wing judges who would gut environmental regulations, and voting against key environmental protection efforts. ...
McCain's outlines environment proposal
guardian.co.uk, UK -
... sweetheart deals, appointing radical right wing judges who would gut environmental regulations, and voting against key environmental protection efforts. ...
Summer Safety
FOX 11 Online, WI -
However, the additional possibility of catching Lyme disease is one more reason to take action against these bugs. Lyme disease is caused by a spiral-shaped ...

Citizen
Battle against superbugs 'being won'
Telegraph.co.uk, United Kingdom - Apr 23, 2008
Ministers claim that the battle against the fatal diseases is being won, although the Opposition say the levels are still unacceptably high. ...
Hospital superbugs in decline, says report The Argus.co.uk
all 207 news articles »
iPod case roundup: classic mashup
Macworld, CA - May 9, 2008
And the Verona Holster is designed for transportation; it?s not a protective case?the leather panels safeguard against minor bumps and bruises, ...

Daily Mail
Ronaldo the great prize for Sir Alex
Daily Mail, UK - May 11, 2008
A command performance in next week's Champions League Final in Moscow, against the Chelsea team who chased United to the wire, would confirm Cristiano's ...
Boosting flood safety requires sacrifice
The Times-Picayune - NOLA.com, LA - May 10, 2008
The corps' decision, expected last month, has been so complex and gut-wrenching that agency decision-makers say they are analyzing all options and have ...
Online orders may be scams, retailers warned
Hamilton Spectator, Canada -
There is virtually no recourse for business owners, nor information about how to protect your business against fraud. Derek Nighbor, vice-president of ...
Source: Google News

Mucin and Toll-like receptors in host defense against intestinal parasites -
DM Moncada, SJ Kammanadiminti, K Chadee - Trends in Parasitology, 2003 - Elsevier
... has a crucial role in immune protection or immune ... a key role in protecting the gut
against enteric pathogens ... focus on the expression of intestinal mucin genes in ...

Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the … -
AP CORFIELD, N MYERSCOUGH, R LONGMAN, P SYLVESTER, … - British Medical Journal, 2000 - gut.bmj.com
... Gut 2000;47:589-594 ( October ) ... Mucins and mucosal protection in the gastrointestinal
tract: new prospects ... that acts as a protective barrier against the harsh ...

Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in … -
M Romano, WH Polk, JA Awad, CL Arteaga, LB Nanney, … - J Clin Invest, 1992 - pubmedcentral.nih.gov
... Gut. 1992 Jan;33(1):30?38. ... [PubMed]; Dupuy D, Szabo S. Protection by metals
against ethanol-induced gastric mucosal injury in the rat. ...

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES: Lessons from … -
FD Finkelman, T Shea-Donohue, J Goldhill, CA … - Annual Reviews in Immunology, 1997 - Annual Reviews
... These observations suggest that eosinophils may contribute less to host protection
against parasites that reside within the gut than to protection against ...

Oral trefoil peptides protect against ethanol-and indomethacin-induced gastric injury in rats -
MW Babyatsky, M deBeaumont, L Thim, DK Podolsky - Gastroenterology, 1996 - Elsevier
... Meth- pus xP4, the frog integumentary mucins FIM-A.1 and ... Time Course of HSP Protection
Against immunoglobulin was quantified by determination of optical ...

Mucosal mast cells and the allergic response against nematode parasites -
HRP Miller - Veterinary Immunology and Immunopathology, 1996 - Elsevier
... possibly through cooperative interaction between the antibodies and mucin glycoproteins
(Miller, 1987 ... 4. Mucosal mast cells and protection against gut nematodes ...

Breast-feeding and the intestinal microflora of the infant ? implications for protection against … -
AE Wold, I Adlerberth - Short and Long Term Effects of Breast Feeding on Child …, 2000 - books.google.com
... milk is predominantly mediated by mucins and depends ... antigen and to normal gut flora. ...
ofthe Infant? 91 Implicationsfor Protection against Infections Diseases ...

Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin -
A Allen, G Flemstrom - American Journal of Physiology- Cell Physiology, 2005 - Am Physiological Soc
... role of this gel layer in mucosal protection is a ... act as a protective physical barrier
against luminal pepsin ... secretions from all regions of the gut have the ...

Gastroduodenal mucosal protection -
A Allen, G Flemstrom, A Garner, E Kivilaakso - Physiological Reviews, 1993 - Am Physiological Soc
... Gastroduodenal mucus bicarbonate barrier: protection against acid and ... at the mouse
gastric surface Gut, December 1, 2004 ... Flow of Zymogenic and Mucin Contents in ...

Passive Protection Against Diarrheal Disease. -
GP Davidson - Journal of Pediatric Gastroenterology and Nutrition, 1996 - jpgn.org
... IgG 1 survives passage through the gut more completely ... 55), and human intestinal
mucins (56), but ... shown to provide complete protection against enterotoxigenic E ...

Source: Google Scholar

Mucins Provide Protection Against Gut Infections
Mucins are large proteins that are secreted on the surface of the gut, and while long regarded as having a role as a barrier to mucosal infection, data to support this theory have been lacking. In a study appearing online in advance of publication in the August print issue of the Journal of Clinical Investigation, Michael McGuckin and colleagues from the University of Queensland, Australia, show that cell surface mucin 1 (Muc1) plays a critical role in protecting the mucosal lining of the gut from bacterial infection.

These authors orally infected mice with the bacterial pathogen Campylobacter jejuni (a common cause of diarrhea) and found that 1 week after infection this organism could be detected in the organs of the vast majority of mice lacking Muc1, but never in mice with intact Muc1.

Although this organism was able to enter the gastrointestinal epithelial cells lining the gut of both Muc1-deficient and Muc1-intact mice, intestinal damage was more common in Muc1-deficient animals, and the authors determined that the prevention of the spread of infection was exclusively due to Muc1 on the surface of gut epithelial cells. This is believed to be the first study in animals to demonstrate that cell surface mucins are a critical component of mucosal defense, and the role of these proteins in epithelial infections and inflammatory disease should be further examined.

TITLE: MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

AUTHOR CONTACT:
Michael A. McGuckin
University of Queensland, South

Source: Brooke Grindlinger
Journal of Clinical Investigation Brisbane, Queensland, Australia.

 

Possible Link Found Between Memory Storage And Addiction

Our experiences -- the things we see, hear, or do -- can trigger long-term changes in the strength of the connections between nerve cells in our brain, and these persistent changes are how the brain encodes information as memory. As reported in Neuron, Johns Hopkins researchers have discovered a new biochemical mechanism for memory storage, one that may have a connection with addictive behavior.

Previously, the long-term changes in connection were thought to only involve a fast form of electrical signaling in the brain, electrical blips lasting about one-hundredth of a second. Now, neuroscience professor David Linden, Ph.D., and his colleagues have shown another, much slower form of electrical signaling lasting about a second can also be persistently changed by experience.

 

They simulated natural brain activity by applying short electrical jolts to slices of rat brain and measuring the current flowing across the cells. After repeated jolting, the strength of the slow nerve signals had dramatically decreased and remained at a low intensity for 30 minutes after electrical jolts ceased.

These slow signals are produced by a nerve cell receptor called mGluR1, which has been associated with behaviors such as addiction and epilepsy. "Both of these conditions also involve long-term changes in the function of nerve connections," says Linden. "So in addition to furthering our basic understanding of memory storage, our work suggests that drugs designed to alter mGluR1 are promising candidates for the treatment of addiction, epilepsy, and diseases of memory."

The research was funded by the Republic of Korea Ministry of Health and Welfare and the National Institutes of Health

Authors on the paper are Paul Worley and Linden of Johns Hopkins and Sang Jeong Kim, Yunju Jin and Jun Kim of Seoul National University College of Medicine

On the Web:
http://neuroscience.jhu.edu/DavidLinden.php
http://www.neuron.org/

Source: Nick Zagorski
Johns Hopkins Medical Institutions
 
 
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