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Recent News and Articles on the Keywords: leukemia diagnosis + using molecular + leukemia  Related to the article below (Last Update: 7/1/2008)

Paul Mischel: All about brains
Journal of Cell Biology (subscription) -
Around that time, Charles Sawyers at UCLA was pioneering the treatment of leukemia patients using signal transduction inhibitors. ...
Stroke Study Reveals Key Target For Improving Treatment And ...
Science Daily (press release) - Jun 22, 2008
But the Karolinska Institutet team will soon begin a clinical trial to test the theory in humans, using the leukemia drug known as imatinib (Gleevec). ...
Leukemia pill may improve stroke treatment
Cancerfacts.com, WA - Jun 24, 2008
June 23, 2008 ? Researchers have found that a drug known as imatinib (Gleevec?), currently used to treat leukemia, might improve emergency treatment for ...

TopCancerNews.com
New therapies that target leukemia stem cells, discovered
TopCancerNews.com, TX - Jun 11, 2008
Stem cell researchers at UCLA have identified a type of leukemia stem cell and uncovered the molecular and genetic mechanisms that cause a normal blood stem ...
A study could change the direction of research into cancer stem ... TopCancerNews.com
all 3 news articles »
Ability To Track Stem Cells In Tumors Could Advance Cancer Treatments
Medical News Today (press release), UK - Jun 19, 2008
Leukemia patients who haven't responded to chemotherapy, for example, may receive bone marrow transplants, through which stem cells of a healthy bone marrow ...
PET Imaging of Cancer Immunotherapy
RedOrbit, TX - Jun 25, 2008
Mice bearing rhabdomyosarcomas were challenged with Moloney murine sarcoma and leukemia virus complex, and induced immune response was monitored via 18F-FDG ...
Financings roundup
TMCnet - Jun 26, 2008
In other financing activity, CardioNet (Conshohocken, Pennsylvania), a wireless med-tech company with an initial focus on the diagnosis and monitoring of ...

New York Times
Cancer as a Disease, Not a Death Sentence
New York Times, United States - Jun 16, 2008
Then a routine checkup resulted in a shocking diagnosis ? chronic myelogenous leukemia, commonly called CML ?My initial disbelief was followed by varying ...
High-Dose vs Standard-Dose Imatinib in Treatment-Naive Patients ...
DG News - Jun 15, 2008
Jorge Cortes, MD, Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, Texas, reported the first findings from the Tyrosine ...
Personalized Medicine: It?s All About You
North American Press Syndicate, NY - Jun 23, 2008
Tests that read the DNA structure of the most-common form of leukemia in children have helped boost the 10-year survival rate from 4 percent in the 1960s to ...
Source: Google News

… discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression … -
EJ Yeoh, ME Ross, SA Shurtleff, WK Williams, D … - Cancer Cell, 2002 - Elsevier
... that worked across the different leukemia subgroups. ... Contemporary approaches to the
diagnosis of pediatric ... Using gene expression profiling, we now demonstrate ...

Unrelated donor marrow transplantation for chronic myelogenous leukemia: 9 years' experience of the … -
PB McGlave, XO Shu, W Wen, C Anasetti, A Nademanee … - Blood, 2000 - bloodjournal.hematologylibrary.org
... risk chronic phase patients with chronic myelogenous leukemia. ... marrow transplant
less than 12 months from diagnosis. ... variables, DFS was worse using marrow from ...

… drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA … -
MA Sanz, FL Coco, G Martin, G Avvisati, C Rayon, T … - Blood, 2000 - bloodjournal.hematologylibrary.org
... have used conventional acute myeloid leukemia-like protocols ... PML/RAR -specific band
visualized at diagnosis, using an RT ... level of 10 4 . Molecular relapse was ...

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression … -
TR Golub, DK Slonim, P Tamayo, C Huard, M … - Science, 1999 - sciencemag.org
... Class predictors were constructed using 50 genes, and ... performed at the time of diagnosis,
before chemotherapy ... were randomly selected from the leukemia cell bank ...

… Recommendations of the International Working Group for Diagnosis, Standardization of Response … -
BD Cheson, JM Bennett, KJ Kopecky, T Buchner, CL … - Journal of Clinical Oncology, 2003 - jco.ascopubs.org
... 29 Data from the Cancer and Leukemia Group B ... immunophenotypic changes in AML patients
between diagnosis and relapse ... 1, can also be assessed using quantitative RT ...

… de novo acute myelogenous leukemia at initial diagnosis: results of molecular and functional assays … -
T Ino, H Miyazaki, M Isogai, T Nomura, M Tsuzuki, … - Leukemia, 1994 - ncbi.nlm.nih.gov
... gp) in 52 adults with de novo acute myelogenous leukemia (AML) at the initial diagnosis.
We tested 52 patients by flow cytometry using the MRK16 monoclonal ...

Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease … -
D Grimwade, FL Coco - Leukemia, 2002 - nature.com
... role in the management of leukemia patients in ... a hematological emergency, rapid
diagnosis is of ... considerable interest in immunofluorescence using polyclonal or ...

Molecular Remission in PML/RARalpha-Positive Acute Promyelocytic Leukemia by Combined All-trans … -
F Mandelli, D Diverio, G Avvisati, A Luciano, T … - Blood, 1997 - bloodjournal.hematologylibrary.org
... As a genetic diagnosis of APL was not required ... compare our data with results obtained
using other protocols ... 28 , 30 Several new acute leukemia entities, which ...

… prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. -
K Inoue, H Sugiyama, H Ogawa, M Nakagawa, T … - Blood, 1994 - ncbi.nlm.nih.gov
... In a patient with acute promyelocytic leukemia, the limits of leukemic cell detection
by RT-PCR using either WT1 or promyelocytic leukemia/retinoic acid ...

High frequency of t (12; 21) in childhood B-lineage acute lymphoblastic leukemia -
SP Romana, H Poirel, M Leconiat, MA Flexor, M … - Blood, 1995 - bloodjournal.hematologylibrary.org
... Overrepresentation of T-cell leukemia samples investigated (compared with the ... 2 using
812Fll ... Table 1. Cytogenetic, FISH, and Molecular Data on Eight Patients ...

Source: Google Scholar

Hope For Improved Leukemia Diagnosis And Treatment Using Molecular Detectors
University of Florida researchers have successfully used molecular probes to detect subtle differences in leukemia cells from patient samples, an achievement that could lead to more effective ways to diagnose and treat cancer.

The strategy, described in a recent issue of Clinical Chemistry, involves engineering short, single strands of DNA or RNA called aptamers to seek out and bind with specific proteins in body fluids.

UF scientists designed the aptamers to bind to cells and molecules associated with leukemia, a cancer of the blood and bone marrow that annually claims about 21,000 lives in the United States, according to the National Cancer Institute.
Researchers also found the first evidence that slight molecular differences can exist even within the same samples from patients with adult T-cell leukemia, a cancer that strikes the immune system's own protective cells.

"Our selective aptamers clearly confirm there are several subcategories of adult T-cell leukemia," said Weihong Tan, Ph.D., a UF Research Foundation professor of chemistry at the College of Liberal Arts & Sciences and a member of the UF Shands Cancer Center. "At present, doctors have had only their experience to rely upon to determine the best treatment for these patients. Our findings will give doctors an effective tool to more precisely make a diagnosis and to tailor treatments."

UF researchers built designer probes using cancer cells as a template, capitalizing on the ability of aptamers to fold into well-defined, three-dimensional structures that bind to targets. The process relies on the fact that different types of cells exhibit unique surface features, so aptamers can recognize and bind with these target cells -- and only these cells -- even in the presence of other, closely related cells.

The scientists found that three of six aptamers they selected for study adhered to all types of cancerous cells but ignored normal blood and bone marrow cells. In combination, the six aptamers produced distinct patterns that characterize different cancer cells, suggesting that the technique could be useful to detect the molecular fingerprints of cancer in people.

The next step toward developing a clinical diagnostic tool involves matching patient data with these molecular profiles. The research team -- working with W. Stratford May, M.D., Ph.D., director of the UF Shands Cancer Center, and Ying Li, M.D., Ph.D., a clinical assistant professor of pathology, immunology and laboratory medicine in the College of Medicine -- has analyzed additional patient samples to build a database that may one day help doctors select the best treatment strategies.

"We are linking the medical histories of patients to specific aptamer binding patterns," said Tan, who is also affiliated with the UF Genetics Institute. "We should soon be able to say patients who belong to this specific molecular binding pattern should have 'such-and-such' treatment. Different molecular patterns of cancer patients will point to different treatments."
Current tests to diagnose leukemia use antibodies, proteins that have the ability to identify harmful substances. But such methods do not capture subtle variances in the molecular signature of cancer cells.

Once an aptamer probe has proved its utility, it can be inexpensively reproduced in a DNA synthesizer.

"Physical scientists mostly use cultured cellular models to demonstrate a principal, and then we leave the findings behind for the biological scientists to use -- if they want," Tan said. "But through collaboration we have pushed the demonstration through to an almost clinical application."

Dihua Shangguan and Zehui Cao of the UF chemistry department and the UF Shands Cancer Center are among the co-authors of the research paper.

Source: John Pastor
University of Florida
 
 
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