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Recent News and Articles on the Keywords: thyroid cancer + aggressive thyroid + thyroid  Related to the article below (Last Update: 5/12/2008)

Vital: Read Your Body Signs
Glasgow Daily Record, UK - May 11, 2008
One woman who knows all about the potential danger of ignoring such signs is Joan Liebmann-Smith who nearly died when her thyroid became seriously ...
Radioactive Iodine Does Not Provide Additional Benefit to Surgery ...
DG News - May 7, 2008
[Presentation title: Neither Total Thyroidectomy Nor Radioiodine Remnant Ablation Improved Long-Term Outcome in 900 Patients With Papillary Thyroid ...
Simultaneous testing for thyroid
Laboratory Talk, UK - Apr 21, 2008
Thyroid cancer varies between slow-growing tumours with a good prognosis, to aggressive tumours with limited treatment options.
NL Focus: Arizona's Davis a hero to many
SportingNews.com - Apr 16, 2008
Davis says both his mother and sister had thyroid cancer and made full recoveries. Davis was confident of his return to the team before the surgery and ...
Determined to fight
Jackson Clarion Ledger, MS - May 5, 2008
Her chemo treatments have been interrupted because of emergency thyroid surgery April 14. "The only thing I got is the good Lord holding cancer back in my ...
Focused, now more than ever
Vallejo Times-Herald, CA - May 11, 2008
Also at that time April was diagnosed with thyroid cancer, Roberts recalls, so he stayed home to help look after Joseph and take care of things. ...
Relay for Life survivor stories: Ever vigilant
McDowell News, NC - Apr 21, 2008
?I found out at that time that I had an aggressive and recurrent thyroid cancer,? said Terri. She was treated again, but it eventually spread to her lymph ...
Abraham Lincoln's death revisited
San Jose Mercury News,  USA - Apr 14, 2008
The condition, which causes aggressive thyroid cancer, explains Lincoln's lanky build, chronic constipation, hooded eyes, asymmetric jaw and the lumps on ...
Ontario's environment ministry guarantees no risk durng PCB removal
LondonTopic.ca, Canada - May 10, 2008
"There is significant studies that link that level to increased risk of heart disease, diabetes, thyroid malfunction, lower IQs, birth deficiencies, cancer, ...
UF researchers identify key target for cancer therapies
Media Newswire (press release), NY - Apr 21, 2008
New therapies must target a key protein interaction to destroy aggressive cancer cells' protective force field, University of Florida scientists reported ...
Source: Google News

Medullary thyroid cancer -
E Kebebew, OH Clark - Current Treatment Options in Oncology, 2000 - Springer
... Although MTC is a relatively rare thyroid cancer, it is one of the more aggressive
thyroid cancers accounting for about 14% of all thyroid cancer deaths [1,2]. ...

Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment -
RF Grossman, SH Tu, QY Duh, AE Siperstein, F … - Archives of Surgery, 1995 - Am Med Assoc
... Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive
treatment. RF Grossman, SH Tu, QY Duh, AE Siperstein ...

High Prevalence of BRAF Mutations in Thyroid Cancer Genetic Evidence for Constitutive Activation of … -
ET Kimura, MN Nikiforova, Z Zhu, JA Knauf, YE … - Cancer Research, 2003 - AACR
... thyroid cell transformation to papillary cancer, although they ... of these effectors
in rat thyroid cells, clones ... in the development of more aggressive tumors is ...

BRAF mutation in thyroid cancer -
M Xing - Endocrine-Related Cancer, 2005 - Soc Endocrinology
... Pepe, G. Troncone, F. Carlomagno, RM Melillo, SM Wilhelm, and M. Santoro BRAF Is
a Therapeutic Target in Aggressive Thyroid Carcinoma Clin. Cancer Res., March 1 ...

… Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid … -
DS Cooper, GM Doherty, BR Haugen, RT Kloos, SL Lee … - Thyroid, 2006 - liebertonline.com
... Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid
Cancer ... Thyroid nodules and pregnancy 4. Differentiated Thyroid Cancer . . . ...

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer -
MD Songtao Wang, RV Lloyd, MJ Hutzler, MS Safran, … - Mod Pathol, 2000 - nature.com
... decreased p27 expression in both papillary and more aggressive carcinomas of ... they
probably have a limited role in malignant progression of the thyroid cancer. ...

BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma -
G Salvatore, V De Falco, P Salerno, TC Nappi, S … - Clinical Cancer Research, 2006 - AACR
... for Cancer Research Cancer Therapy: Preclinical. BRAF Is a Therapeutic
Target in Aggressive Thyroid Carcinoma. Giuliana Salvatore ...

Graves'disease and thyroid cancer. -
R Behar, M Arganini, TC Wu, M McCormick, FH Straus … - Surgery, 1986 - ncbi.nlm.nih.gov
... Thyroid cancer associated with Graves' disease is found more ... be treated with total
thyroid ablation rather ... at risk of developing aggressive thyroid cancers if ...

Risk factor analysis in differentiated thyroid cancer.
B Cady, CE Sedgwick, WA Meissner, MS Wool, FA … - Cancer, 1979 - ncbi.nlm.nih.gov
... Less aggressive biologic behavior of thyroid cancer before the age of menopause
implies that an estrogen-rich milieu may alter the effects of initiating and ...

… and surgical management of locoregional lymph node metastases in papillary thyroid cancer -
GFW Scheumann, O Gimm, G Wegener, H Hundeshagen, H … - World Journal of Surgery, 1994 - Springer
... aggressive papillary thyroid cancer. N1 status did not influence survival of patients
with T4 tumor but did influence those with T1-T3 status (p < 0.001). The ...

Source: Google Scholar

Thyroid cancer treatment may be overly aggressive

Last Updated: 2007-08-01 14:12:33 -0400 (Reuters Health)

By Will Boggs, MD

NEW YORK (Reuters Health) - Thyroid cancers that are clinically insignificant - and may never cause serious disease -- may be treated too aggressively in some patients, according to the author of the 2006 Hayes Martin Lecture, published in the Archives of Otolaryngology-Head and Neck Surgery.

Physicians need to be more selective in how aggressively they evaluate patients who have low-risk thyroid cancer in the earliest stages and stable thyroglobulin levels, Dr. Keith S. Heller told Reuters Health. Elevated or rising levels of thyroglobulin, a protein produced in the thyroid gland, may indicate the presence of thyroid cancer. However, elevated thyroglobulin is also caused by many benign conditions.

Heller from New York University School of Medicine, New York, contends that several of the American Thyroid Association guidelines for the treatment of patients with thyroid nodules or stage 1 thyroid cancer may lead to overly aggressive treatment. In particular, the use of sonography, and how much of a thyroglobulin elevation requires further evaluation, need to be reconsidered.

After reviewing some of the articles that led to these guidelines, Heller asserts: "All of these studies, guidelines, and recommendations lack data that prove that the presence of these minimally involved lymph nodes in any way affects the patient's prognosis." There is also no evidence that the removal or treatment of these lymph nodes improves patients' survival.

"I find these guidelines very troubling for those reasons."

In Heller's personal experience with 360 patients younger than 45 years at the time of initial treatment for differentiated thyroid cancer, 99 percent are still alive. Three died from causes unrelated to thyroid cancer and only one died of thyroid cancer.

Similarly, among 449 of his older patients with previously untreated differentiated thyroid cancer, 91 percent are alive, and of the 40 patients who died, only 8 died of thyroid cancer.

"My objection is not that the guidelines are wrong, but that they need to be clearer in using risk stratification to determine which patients need to be the subject of which guidelines," Heller said.

"In many ways the ability to detect microscopic metastatic thyroid cancer creates a dilemma similar to that faced by urologists when an elevated PSA leads to the detection of microscopic prostate cancer," he pointed out. "Clearly, not all of these need to be treated."

He concludes: "We have embarked on a quixotic quest to rid our patients of microscopic and probably clinically unimportant thyroid cancer. We need to refocus our efforts, not to detect more occult disease, but to identify and cure those few patients whose disease is likely to shorten their lives."

SOURCE: Archives of Otolaryngology-Head and Neck Surgery, July 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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