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Recent News and Articles on the Keywords: parkinson's disease + early recognition + early  Related to the article below (Last Update: 5/5/2008)

Loss of smell may precede Parkinson's disease
Tehran Times, Iran - Apr 15, 2008
""Olfactory screening could help in the early detection of Parkinson's disease before the typical motor signs are evident,"" lead investigator Dr. G. ...
Region native Kristy Follmar helps knock out Parkinson's disease
nwitimes.com, IN - Apr 20, 2008
Rock Steady received national recognition for its success stories when it was featured on ABC World News in early March. Follmar said the attention has ...
REPORT FOR FIRST QUARTER 2008
Ad-Hoc-News (Pressemitteilung), Germany - Apr 29, 2008
With funding from the Michael J. Fox Foundation, development of aproduct for early diagnosis of Parkinson's disease was initiated. ...
US jazz clarinetist Jimmy Giuffre dead at 86
AFP - Apr 26, 2008
He died of pneumonia and complications from Parkinson's disease, it said. A musician with multiple talents, Giuffre played the saxophone and flute, ...
Sick and Famous
American Enterprise Institute, DC - Apr 11, 2008
In the early years of the twentieth century, regardless of a person's prominence, the subject of illness and disease was deeply personal and considered ...
'And our cause is just'
Arizona Daily Star, AZ - Apr 11, 2008
Bob reports moderate Parkinson's disease symptoms in most categories. "I'm afraid when I don't know every fifth word or sixth word," says Bob. ...
Free will? Not as much as you think
Boston Globe, United States - Apr 13, 2008
In the future, research in the field could help people with neurological motor disorders such as Parkinson's disease. It also could identify people whose ...
The Great McCain Story You've Probably Forgotten
Slate - Apr 9, 2008
For the past few years, Udall has lain ill with Parkinson's disease in a veterans hospital in Northeast Washington, which is where we were heading. ...

Daily Peloton
Cycling News Roundup - 17 April 2008
Daily Peloton - Apr 18, 2008
The Sea Otter Classic benefits the Davis Phinney Foundation, which supports Parkinson's disease research and wellness, and IMBA California, which organizes ...
Power3 Medical Products Issues Letter to Shareholders
Centre Daily Times, PA - Apr 21, 2008
I am confident that Power3 is on the path to successful commercialization of our blood serum diagnostic tests for the early detection of disease. ...OTC:PWRM
Source: Google News

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 -
EM Valente, PM Abou-Sleiman, V Caputo, MMK Muqit, … - Science, 2004 - sciencemag.org
... affect kinase activity or substrate recognition. ... can be indistinguishable from
idiopathic Parkinson disease. ... in autosomal recessive early-onset parkinsonism. ...

COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE -
AJ LEES, E SMITH - Brain, 1983 - Oxford Univ Press
... Our study shows that even in the early stages of Parkinson's disease slight difficulty
in ... could be found on the two-choice recognition memory test. ...

Cognitive impairments associated with early Parkinson's disease -
BE Levin - Neurology, 1989 - AAN Enterprises
... and 41 controls to assess the early neuropsychological changes associated with
Parkinson's disease (PD). Parkinson subjects did as well as controls on ...

Effects of Coenzyme Q10 in Early Parkinson Disease Evidence of Slowing of the Functional Decline -
CW Shults, D Oakes, K Kieburtz, MF Beal, R Haas, S … - Archives of Neurology, 2002 - Am Med Assoc
... Parkinson disease affects approximately 1% of Americans older than ... 5-6 Recognition
that 1-methyl-4-phenyl-1 ... demonstration that patients with early, untreated PD ...

Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations -
K Hedrich, K Marder, J Harris, M Kann, T Lynch, H … - Neurology, 2002 - AAN Enterprises
... be expected solely because of earlier recognition of disease ... frequent than Parkin
(PARK2) mutations in early-onset Parkinson disease Neurology, February ...

Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in … -
SJG Lewis, A Dove, TW Robbins, RA Barker, AM Owen - Journal of Neuroscience, 2003 - neuroscience.org
... cognitive tests with less executive loading (eg, visual recognition memory ... Smith
E (1983) Cognitive deficits in the early stages of Parkinson's disease. ...

The performance on learning tasks of patients in the early stages of Parkinson's disease. -
AG Canavan, RE Passingham, CD Marsden, N Quinn, M … - Neuropsychologia, 1989 - ncbi.nlm.nih.gov
Neuropsychologia. 1989;27(2):141-56. Click here to read The performance on learning
tasks of patients in the early stages of Parkinson's disease. ...

Loss of olfaction in de novo and treated Parkinson's disease: Possible implications for early -
G Tissingh, HW Berendse, P Bergmans, R DeWaard, B … - Movement Disorders, 2001 - doi.wiley.com
... Hurtig HI. Bilateral olfactory dysfunction in early stage treated and
untreated idio- pathic Parkinson?s disease. J Neurol ...

Early cognitive changes and nondementing behavioral abnormalities in Parkinson?s disease -
BE Levin, HL Katzen - Behavioral Neurology of Movement Disorders, 1995 - books.google.com
... how prominent these changes are in the early stages of the disease. ... 88 PARKINSON'S
DISEASE that the earliest visuospatial changes reflect an executive ...

Spatial disorientation as an early symptom of Parkinson's disease -
A Hovestadt - Neurology, 1987 - AAN Enterprises
... Spatial disorientation as an early symptom of ... 44 consecutive outpatients with idiopathic
Parkinson's disease (PD) without ... and on the facial recognition test in ...

Source: Google Scholar

Early Recognition Of Parkinson's Disease

Specialists of the brain investigation department of the Scientific Research Institute of Neurology, Russian Academy of Medical Sciences, are developing methods for early pre-clinical recognition of Parkinson's disease. The method is based on the fact that even at early stages of the disease, the patients' head, eye and hand movement parameters change.

Parkinson's disease is one of the most widespread neurodegenerative diseases. It develops as a result of injuries of 60 to 80 percent of neurons in a single part of the brain. It is important to find the way to "catch" the disease before neuron degeneration reaches the critical level, and the patient starts suffering from tremor and movement disorders.
To find reliable methods of early diagnostics, the Moscow neurologists examined 12 healthy probationers and 16 patients suffering from the first and the second stages of Parkinson's disease. The participants to the experiment were tested with the help of the hardware and software complex, which analyzes the moving activity. The probationers were (by moving the eyes only) to fix the look on the target, which was shifting across at the angle of 40 degrees. They were suggested to make sliding movements by the head to the left and to the right along the horizontal plane, retaining the look on the target, which moved synchronously with the head movements. And, finally, after several open-eye training sessions, the participants transferred the cursor onto the target by memory, their eyes being curtained off. These three tests allow to check how the patients move separate parts of the body (only eyes, head or hand). In the course of the fourth test, the probationers shifted the cursor from one target to another by moving the eyes, head and hand, i.e. by coordinating their movements.

At the early stage of the disease, individual movements' indices were changed with the patient, but these changes differed slightly from the age standard. However, all parameters of coordinated movement with Parkinson's disease patients reliably differed from those of healthy probationers. Apparently, at the early stage of the disease, the brain is still able to impede the disease development and to compensate for movement disorders. That is why, although each individual movement occurs with a mistake, the mistake is minimal, and it is not always possible to reveal it. However, in case of coordinated movement all these minor delays, inaccuracies in movements and multistage of movements "superimpose" upon each other, and movement disorders become evident.

The researchers assume that it is the coordinated movement disorder that can be considered as one of the markers for early stage of Parkinson's disease. Analysis of such disorders drastically increases the probability of early disease recognition. Nevertheless, the authors of the hypothesis emphasize that this is only a hypothesis so far, and further experiments are need to verify it.

INFORMNAUKA (INFORMSCIENCE) AGENCY
http://www.informnauka.ru/eng

Investigating The Causes Of Parkinson's Disease

A University of Nottingham researcher has been awarded more than £440,000 by the Parkinson's Disease Society (PDS) to investigate the causes of the condition.

Dr Lynn Bedford, of the School of Biomedical Sciences, will lead a five-year study after receiving an award from the PDS under its Career Development Awards Scheme, which aims to support the careers of the UK's most promising individuals working in Parkinson's research.

Dr Bedford will be using a new genetic model of Parkinson's to further understanding of how and why nerve cells die. Her research will also take a closer look at the reasons for the formation of Lewy bodies a build-up of proteins within nerve cells in the brains of people with Parkinson's.

This study is aimed at providing a platform for the development of drugs to stop nerve cell death.

Dr Kieran Breen, Director of Research and Development for the Parkinson's Disease Society, said: "Researchers are the people who make the discoveries and forge the links between different research areas so clearly investing in people is key to furthering our understanding of Parkinson's.

"The Career Development Awards Scheme is aimed at increasing the number of people involved in Parkinson's research and encouraging the UK's top researchers of the future to specialise in Parkinson's."

Parkinson's is a progressive neurological condition caused by the death of nerve cells in the brain that produce the chemical dopamine, which is responsible for movement. The condition affects movements such as walking, talking, and writing. Its three main symptoms are tremor, muscular rigidity, and slowness of movement. Parkinson's is a very individual condition and the rate and nature of progression varies from person to person.

Dr Bedford said: "I have been involved in Parkinson's disease research for the last five years so I am delighted to get this Career Development Award. This novel model of Parkinson's will be crucial in helping to uncover and study why nerve cells die in the region of the brain affected in Parkinson's disease.

"At Nottingham we have an excellent team who are committed to understanding this model. I look forward to driving this interesting new avenue of research and interacting with individuals, both researchers and clinicians, in the field of Parkinson's."

Approximately 120,000 people in the UK have Parkinson's, and 10,000 are diagnosed with the condition every year. Although more common in people aged over 60, about one in 20 of those diagnosed each year are under 40.

Dr Breen added: "The Parkinson's Disease Society is very pleased to be funding Dr Bedford's study. Furthering our understanding of the causes of Parkinson's will hopefully lead to the development of new treatments for the condition, making a difference to the lives of the 120,000 people in the UK with Parkinson's."

The PDS has spent more than £30m on research since 1969, including almost £4m in 2006. Studies funded use basic and applied science as well as health and social care projects to investigate the causes, treatment, prevention and cure for Parkinson's.

The Parkinson's Disease Society (PDS) is the UK's leading authority on all aspects of the condition. The charity campaigns for a better quality of life for people with Parkinson's. The PDS provides field staff and local information and maintains 300 branches.

NOTTINGHAM UNIVERSITY
University Park
Nottingham
NG7 2RD
http://www.nottingham.ac.uk
 
 
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