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Recent News and Articles on the Keywords: brain regions + placebo effect + effect  Related to the article below (Last Update: 5/12/2008)


Xinhua
Why People Engage In Risky Behavior While Intoxicated: Imaging ...
Science Daily (press release) - Apr 30, 2008
The study, in the April 30 issue of The Journal of Neuroscience, is the first human brain imaging study of alcohol's effect on the response of neuronal ...
Alcohol Dulls the Brain?s Ability to Feel Fear: Study HealthJockey.com
all 69 news articles »
Hormone Linked to Food Appeal and Eating
MedPage Today, NJ - May 7, 2008
"These regions encode the salience and the hedonic and incentive value of visual cues," the authors said. "This effect likely accounts for the ability of ...

HealthJockey.com
Ghrelin hormone makes food look more delicious: Research
HealthJockey.com, India - May 7, 2008
The effect was that there was increased response to food pictures because of ghrelin and in other areas of brain involving salience and hedonic incentive ...
Endocrinology & Metabolism News, May 2008
Journal of Clinical Endocrinology and Metabolism, MD - May 7, 2008
This protective effect was still observed even after the removal of confounding factors such as family history, birthweight, presence of maternal diabetes, ...
The μ-Opioid System and Antidepressant Response: How the Opioid ...
Psychiatric Times, NY - Apr 15, 2008
... increased activation of specific brain regions over the sustained pain condition. The placebo effect may be mediated by the endogenous opioid system. ...
Volunteers sought to test vitamin D memory effect
The West Australian, Australia - Apr 13, 2008
... Starkstein and Professor David Bruce, will use neuro-imaging techniques to examine the association between apathy and abnormalities in brain regions. ...

InTheNews.co.uk
New report shows why drunk people favour a fight
InTheNews.co.uk, UK - Apr 29, 2008
"By showing that alcohol exerts this effect in normal volunteers by acting on specific brain circuits, these study results make it harder for someone to ...
Update in Sleep and Control of Ventilation 2007
RedOrbit, TX - May 2, 2008
This was the first demonstration of a direct cause-and-effect relationship between intermittent hypoxia and development of acute insulin resistance in ...
A Preliminary Attempt to Personalize Risperidone Dosing Using Drug ...
Psychosomatics (subscription) - Apr 30, 2008
Typically, studies for approving drugs focus on significance, but another statistical concept, effect size, may be more relevant to clinical practice, ...
AAN: Promising Long-Term Results for Oral MS Drug
MedPage Today, NJ - Apr 16, 2008
Gadolinium-enhancing lesions on MRI, which reflect recent activation of brain regions in acute inflammation, were down to a mean of 0.1 to 0.3 per patient ...
Source: Google News

[PDF] The Functional Neuroanatomy of the Placebo Effect -
HS Mayberg? - American Journal of Psychiatry, 2002 - science.mcmaster.ca
... Second, while comparable brain changes were seen with ... was active fluoxetine or placebo,
was associated ... changes in specific cortical and paralimbic regions. ...
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Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks -
SE Shaywitz, BA Shaywitz, KR Pugh, RK Fulbright, P … - JAMA, 1999 - Am Med Assoc
... crossed over with identical placebo and a ... the hemisphere encoding/retrieval asymmetry
(HERA) effect. ... postmenopausal women in specific brain regions during the ...

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain -
TD Wager, JK Rilling, EE Smith, A Sokolik, KL … - Science, 2004 - sciencemag.org
... have no intrinsic pharmacological effects may produce ... experiments, we found that
placebo analgesia was ... activity in pain-sensitive brain regions, including the ...

The neural correlates of placebo effects: a disruption account -
MD Lieberman, JM Jarcho, S Berman, BD Naliboff, BY … - Neuroimage, 2004 - Elsevier
... Though a drug and a placebo may both affect brain region X, the drug may do so directly,
whereas placebo effects are typically mediated by placebo-induced ...

Estrogen Therapy in Postmenopausal Women Effects on Cognitive Function and Dementia -
K Yaffe, G Sawaya, I Lieberburg, D Grady - JAMA, 1998 - Am Med Assoc
... serotonergic activity in specific brain regions, maintenance of ... studies have measured
the effect of postmenopausal ... Large placebo-controlled trials are required ...

Modulation of Cortical-Limbic Pathways in Major Depression: Treatment-Specific Effects of Cognitive … -
K Goldapple, Z Segal, C Garson, M Lau, P Bieling, … - Archives of General Psychiatry, 2004 - archpsyc.highwire.org
... changes with CBT in these regions may reflect ... Brain changes with placebo response,
in fact, directly shadowed ... Obviously, a placebo-controlled CBT trial will be ...
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Placebo and Opioid Analgesia--Imaging a Shared Neuronal Network -
P Petrovic, E Kalso, KM Petersson, M Ingvar - Science, 2002 - sciencemag.org
... analgesia, we suggest that these regions belong to a ... How the Doctor's Words Affect
the Patient's Brain. ... Bases for Reward: Implications for the Placebo Effect. ...

The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation … -
EA Mayer, S Berman, SWG Derbyshire, B Suyenobu, L … - Alimentary Pharmacology & Therapeutics, 2002 - pt.wkhealth.com
... Some of these regions have a high density of 5-HT 3 receptors in the human brain,
particularly the ... irritable bowel syndrome drug in a placebo-controlled study ...

Neurobiological Mechanisms of the Placebo Effect -
F Benedetti, HS Mayberg, TD Wager, CS Stohler, JK … - Journal of Neuroscience, 2005 - neuroscience.org
... independence, by a number of brain regions with complex ... in some but not other regions
(Fig. ... in the subsequent regional neurochemical responses to placebo. ...

Effect of Amitryptiline on Symptoms, Sleep, and Visceral Perception in Patients With Functional … -
H Mertz, R Fass, A Kodner, F Yan-Go, S Fullerton, … - American Journal of Gastroenterology, 1998 - Blackwell Synergy
... Therefore we believe that placebo effect was unlikely to have played a ... imaging
techniques may allow further definition of the brain regions responsible for the ...

Source: Google Scholar

The Placebo Effect Explained Through Identification Of Relevent Brain Region
Researchers have pinpointed a brain region central to the machinery of the placebo effect -- the often controversial phenomenon in which a person's belief in the efficacy of a treatment such as a painkilling drug influences its effect.

The researchers said their findings with human subjects offer the potential of measuring the placebo effect and even modulating it for therapeutic purposes. They also said their findings could enable measurements of brain function that "would help determine dysfunctions in cerebral mechanisms that may impair recovery across a number of conditions."

Jon-Kar Zubieta and colleagues published their findings in the journal Neuron, published by Cell Press.
Their studies concentrated on a brain area known as the nucleus accumbens (NAC), a region deep in the brain, known to play a role in expectation of reward. Earlier studies had hinted at involvement of the NAC in the placebo effect, but the nature of that role was unknown, said the researchers.

In their experiments, the researchers told volunteers that they were testing the effects of a new pain-killing drug and that the subjects might receive the drug or a placebo. However, in the experiments, the researchers gave only a placebo injection of a salt solution. The experiments involved asking the subjects to rate their expectation of the pain-killing effects of the "drug" and also the level of pain relief with or without the "drug" that they felt from a moderately painful injection of salt solution into their jaw muscle.

In one set of experiments, the researchers used a molecular tracer scanning technique known as Positron Emission Spectroscopy to measure release from the NAC of the neurotransmitter dopamine - a chemical trigger of the brain's reward response. They found that the greater subjects' anticipation of the pain-killing benefit of the placebo, the greater the dopamine release from the NAC. Also, subjects who reported greater relief from the placebo when they did experience pain showed greater NAC activity when they received the placebo before the pain.

In separate experiments, the researchers studied whether activation of subjects' NAC during reward processing correlated with the magnitude of their placebo effect. They told subjects to expect monetary rewards of different amounts, as their brains were scanned using functional magnetic resonance imaging. The researchers found that the people who showed greater activation of the NAC during this reward-expectation task also showed a greater anticipation of effectiveness of a placebo.

The researchers concluded that "These findings are consistent with the hypothesis that this system is involved in the encoding of the 'incentive value' of the placebo, possibly acting as a gate or permissive system for the formation of placebo effects."

They wrote that "The placebo effect then emerges as a resiliency mechanism with broad implications that, given its activation of specific circuits and mechanisms, can be both examined and modulated for therapeutic purposes."

The researchers include David J. Scott, Christine M. Egnatuk, Heng Wang, Robert A., Koeppe, and Jon-Kar Zubieta of The University of Michigan, Ann Arbor; Christian S. Stohler of University of Maryland, Baltimore. This work was supported by grants R01 AT 001415 and R01 DA 016423 to J.K.Z. and R01 DE 15396 to C.S.S.

Scott et al.: "Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects." Publishing in Neuron 55, 325-336, July 19, 2007. DOI 10.1016/j.neuron.2007.06.028. http://www.neuron.org/.

Source: Erin Doonan
Cell Press
 
 
 
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