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Recent News and Articles on the Keywords: with surprising + novel biomaterial + novel  Related to the article below (Last Update: 5/12/2008)

Arthur Hart: Idaho county names hold some surprising origins
IdahoStatesman.com, ID - 31 minutes ago
By Arthur Hart - Special to the Idaho Statesman There are 25 counties in the United States named Franklin, but the one in Idaho is the only one not named ...

Washington Post
Mayo saga not at all surprising
Palm Beach Post,  United States -
By Dave George One and done. It's the definition of disaster in the NCAA basketball tournament, and USC guard OJ Mayo had the shock of experiencing it in ...
OJ Mayo's Not The Sharpest Trojan In The Jar Deadspin
Mayo case may affect NCH Cincinnati Enquirer
MONDAY MORNING QUARTERBACK Fort Worth Star Telegram
all 583 news articles »
Pineiro part of surprising rotation
MLB.com - May 11, 2008
By JR Radcliffe / Special to MLB.com MILWAUKEE -- One of the main reasons prognosticators expected the St. Louis Cardinals to struggle before the season was ...
Surprising Ways You Can Save Big Bucks In Bad Economy
North American Press Syndicate, NY -
(NAPSI)-Are you wasting your money? You? No way, because you shop the sales, you?ve switched from premium brands to store labels, and you?ve even given up ...
MARCH: Scott gets a surprising job as bodyguard to the Fratellis ...
Cambs Times, UK -
AT four-and-a-half feet tall, Scott English may not seem your average bodyguard. But that's just the job the March man carried out on Saturday, ...
CBC's struggle with its mandate disheartening, surprising
Hill Times (subscription), Canada -
To realize that the CBC appears to be struggling with its mandate is quite surprising and rather disheartening. Instead of sponsoring concerts, plays, ...
Surprising success: Cazal Arnett
Binghamton University Pipe Dream,  USA - May 11, 2008
Before his days of breaking record after record during his freshman track and field campaign at Binghamton University, he was just another sprinter on a ...
U-Md. Students Bring Their Real-Money Fund Home to a Surprising Finish
Washington Post, United States - May 10, 2008
By Nancy Trejos There were some rocky moments for the 10 business-school students responsible for investing $1.2 million in a fund belonging to the ...

OverTheLimit.info
Obama shares 10 surprising facts
Independent, UK - May 2, 2008
On Thursday, it was the top 10 surprising facts about Barack Obama, delivered by the candidate himself via satellite link from Bend, Indiana, where he is in ...
Obama reveals Top 10 'surprising facts' on Letterman The Associated Press
Top 10 Surprising Facts About Barack Obama TheImproper.com
No space for Clinton, pastor in Obama top 10 list NEWS.com.au
Reuters - Dallas Morning News
all 259 news articles »

Bleacher Report
Surprising Goydos has 1-shot lead at TPC
Sun-Sentinel.com, FL - May 11, 2008
By Randall Mell | South Florida Sun-Sentinel He knows he's dumbfounding golf with his unexpected run atop the leaderboard heading into today's final round ...
Goydos cool during surprising rise to TPC lead MLive.com
Surprising Goydos Out in Front The Ledger
SERGIO SURGES Electric New Paper
Winnipeg Sun
all 2,655 news articles »
Source: Google News

Biomaterial-Induced Sarcoma A Novel Model to Study Preneoplastic Change -
CJ Kirkpatrick, A Alves, H Kohler, J Kriegsmann, F … - American Journal of Pathology, 2000 - ASIP
... A Novel Model to Study Preneoplastic Change. ... the vicinity of the biomaterials, some
surprising results were ... adjacent to the site of the biomaterial to complete ...

Nanoelectronics and Information Technology: Advanced Electronic Materials and Novel Devices -
R Waser - MRS BULLETIN, 2004 - mrs.org
... Overall, this book covers an impressive variety of ... minerals, coatings, construction
materials, biomaterials, pigments, dyes ... also has some surprising omis- sions ...

… stability of collagen porous scaffolds by using amino acids as novel cross-linking bridges -
L Ma, C Gao, Z Mao, J Zhou, J Shen - Biomaterials, 2004 - Elsevier
... scaffolds by using amino acids as novel cross-linking ... However, the surprising results
were gotten in the ... 1. Wolfgang, Collagen-biomaterial for drug delivery. ...

Pyrolysis Mass Spectrometry of Recent and Fossil Biomaterials -
HLC Meuzelaar, J Haverkamp, FD Hileman - Compendium and Atlas, Elsevier, Amsterdam, 1982 - doi.wiley.com
... Nevertheless, it is surprising that the authors who have ... The book consists of two
parts; roughly a third ... in detail in Chapter 3 with reference to biomaterials. ...

Small intestinal submucosa as a small-caliber venous graft: A novel model for hepatocyte … -
SS Kim, S Kaihara, MS Benvenuto, BS Kim, DJ Mooney … - Journal of Pediatric Surgery, 1999 - Elsevier
... characteristics of the SIS, it had surprising integrity and ... gated as a biomaterial
for tissue remodeling in animal ... mesh, this model provides a novel method for ...

Biomaterials and Scaffolds in Reparative Medicine -
EL CHAIKOF, H MATTHEW, J KOHN, AG MIKOS, GD … - Annals of the New York Academy of Sciences, 2002 - Blackwell Synergy
... For example, most natural "biomaterials" possess a composite ... it should not be surprising
that modifications ... For example, novel materials based on human elastin ...

-
MD Lauren - US Patent 4,755,593, 1988 - Google Patents
... NOVEL BIOMATERIAL OF CROSS-LINKED ... {o ^ e biomaterial ... This is not surprising, as direct
isometric tension measurements are usually needed to verify such 15 ...

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue … -
MP Lutolf, JA Hubbell - Nature Biotechnology, 2005 - eng.uwo.ca
... its key features, it is not surprising that synthetic ... formation and regeneration
necessitates novel design strategies for synthetic biomaterials (Fig ...

[PDF] Biotin-derivatized poly (L-lysine)-g-poly (ethylene glycol): A novel polymeric interface for … -
NP Huang, J Voros, SM De Paul, M Textor, ND … - Langmuir, 2002 - textorgroup.ch
... A novel biosensor interface exploiting the spontaneous surface assembly of a
polycationic, PEG ... I.; De Paul, SM; Textor, M.; Spencer, ND Biomaterials, submitted. ...
-

Biaxial Mechanical Response of Bioprosthetic Heart Valve Biomaterials to High In-plane Shear -
W Sun, MS Sacks, TL Sellaro, WS Slaughter, MJ … - Journal of Biomechanical Engineering, 2003 - link.aip.org
... protocol, it was not surprising that Eq ... In the current study, several novel modeling
problems ... used previously , even though we utilized identical biomaterials. ...

Source: Google Scholar

University of Delaware scientists have invented a novel biomaterial with surprising antibacterial properties that can be injected as a low-viscosity gel into a wound where it rigidifies nearly on contact--opening the door to the possibility of delivering a targeted payload of cells and antibiotics to repair the damaged tissue.
Regenerating healthy tissue in a cancer-ridden liver, healing a biopsy site and providing wounded soldiers in battle with pain-killing, infection-fighting medical treatment are among the myriad uses the scientists foresee for the new technology.

The patented invention by Joel Schneider, UD associate professor of chemistry and biochemistry, and Darrin Pochan, associate professor of materials science, and their research groups marks a major step forward in the development of hydrogels for medical applications.
Formulating hydrogels as delivery vehicles for cells extends the uses of these biopolymers far beyond soft-contact lenses into an intriguing realm once viewed as the domain of science fiction, including growing bones and organs to replace those that are diseased or injured.

"This is an area that will be exploding over the next decade," Pochan said.

Hydrogels are formed from networks of super-absorbent, chain-like polymers. Although they are not soluble in water, they soak up large amounts of it, and their porous structure allows nutrients and cell wastes to pass right through them.

Schneider and Pochan and their research teams have been focusing on developing peptide-based hydrogels that, once implanted in the human body, will become scaffolds for cells to hold onto and grow--cells such as fibroblasts, which form connective tissue, and osteoblasts, which form bone.

"They're like rebar when you're building something with concrete," Schneider said. "They give the cement something to hang onto."

The basis of UD's hydrogels is "MAX1," a self-assembling peptide that the scientists designed six years ago and named after Pochan's son, Max.

Peptides are short chains of amino acids, the building blocks of proteins. Different amino acids are bonded together to form chains, which then fold up into more compact shapes with specific functions.

The peptide that Schneider and Pochan and their research teams designed undergoes triggered "self-assembly," meaning that the peptide will fold automatically into a specific shape in response to a particular trigger, or environmental stimulus, such as exposure to light. After folding, it self-assembles, affording the hydrogel.

Using "MAX8," the eighth iteration of their original peptide, Lisa Haines-Butterick, a doctoral student in Schneider's group, figured out how to encapsulate living cells in the hydrogel and then inject the gel into secondary sites without harming the cells.

"Although we have currently only demonstrated this capacity of our gels using simple models, we envision that when injected into the body, the cells encapsulated in the gel can go about their business in restructuring the tissue," Schneider explained.
UD's peptide-based hydrogels display several novel features. Not only are they cytocompatible, meaning that they are not toxic to the living cells they are enlisted to deliver, but some of the gels are inherently antimicrobial, killing certain gram-negative and gram-positive bacteria, a characteristic the research team currently is exploring.

The UD hydrogels also can be freeze-dried into a powder and reconstituted into a solution for use. They can be injected from a syringe, offering a minimally invasive approach to medical treatment, as well as a targeted, "leak-proof' way of potentially delivering cells and drugs to a wound or diseased organ.

Collaborations with physicians at Christiana Care Health System in Newark, Del., may lead to future developments for the hydrogels. Schneider recently began working with Dr. Joseph Bennett, a surgeon at the Helen F. Graham Cancer Center who resects liver tumors.

Both Schneider and Pochan attribute this new collaboration to the Center for Translational Cancer Research, a collaboration of Christiana Care Health System, A. I. duPont Hospital for Children and UD, including the University's Delaware Biotechnology Institute. The center is under the direction of Mary C. Farach-Carson a professor of both biological sciences and material sciences at UD.

"You know, the liver is an amazing organ," Schneider said. "It has the ability to regenerate itself quite easily. If almost 70 percent of it is lost to disease and removed, that remaining 30 percent can grow back, affording a functional liver. We want to use the hydrogels to deliver hepatocytes to the liver," he noted. "These could be used to beef up the liver's function prior to surgery if, for example, someone had hepatitis, or drank a lot, factors that would normally limit the amount of cancerous liver that can be removed."

While Schneider and Pochan aren't Felix and Oscar in The Odd Couple, they do work in very different scientific disciplines, and they have an easy banter.

Both scientists joined the UD faculty in 1999. They met during new faculty orientation at the president's house, seated at the same table.

"Serendipity can really be your friend," Pochan said.

Besides learning about each other's research, Pochan and Schneider also found out they lived in the same neighborhood in Philadelphia, although at different times (Schneider during postgraduate research at the University of Pennsylvania, and Pochan during his first years at UD), and even had some of the same mutual friends there.

"What are the odds"" Schneider said.

Both scientists have since gone on to win the National Science Foundation's prestigious Faculty Early Career Development Award in 2004 and the DuPont Young Professor Award (Pochan in 2002 and Schneider in 2005). Schneider also received the Francis Alison Society's Young Scholars Award in 2003, and Pochan is this year's recipient of the American Physical Society's John H. Dillon Medal.

"The thing is, he used to throw these things away," Pochan said, referring to the hydrogels and pointing his thumb at Schneider.

"For the research I was working on when I was a graduate student a long time ago, the last thing I wanted to make was hydrogels," Schneider explained, "so when that's what I ended up with, I'd throw them out. Then Darrin said to me, 'You know, these things are really pretty interesting....'

"It's been a very successful collaboration," Schneider added. "A whole host of terrific students and other people on- and off-campus have helped this come to fruition," he noted. "Without these students and collaborators, this work would be impossible."

Schneider and Pochan's most recent hydrogel study is reported in the May 8 (print) edition of the Proceedings of the National Academy of Sciences. Their research is funded by the National Science Foundation and the National Institutes of Health.

The University of Delaware is pursuing commercialization opportunities for the research. Patents have been filed in the United States, Canada, Europe and Japan.

Source: Tracey Bryant
University of Delaware
 
 
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