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Recent News and Articles on the Keywords: side effects + better understanding + reduction  Related to the article below (Last Update: 5/5/2008)

Q1 2008 Quest Diagnostics Earnings Conference Call - Final
Insurance News Net (press release), PA -
During the quarter, we reduced debt by $113 million, bringing our total debt reduction since the AmeriPath acquisition to more than $500 million. ...DGX
What CATIE Did: Some Thoughts on Implications Deep and Wide
Psychiatric Services (subscription) - May 1, 2008
It is a high-potency, relatively D 2 -selective compound with a high?possibly uniquely high?propensity to induce extrapyramidal side effects (8), ...
White Mountains Reports Tangible Book Value Per Share of $443
PR Newswire (press release), NY - May 2, 2008
We realized a 3-point reduction in our expense ratio as we lowered acquisition costs and continued to scale the business." Gross written premiums were $231 ...OB - BRK.A
Riding on the next wave of promise
EnergyCurrent, TX - May 1, 2008
A lack of understanding and consensus on wave energy's environmental, social and economic impacts also persist in some parts of the world. ...
In the shadow of debt
Inquirer.net, Philippines - Apr 25, 2008
Trade liberalization had fiscal effects. If the hemorrhage of payments on the foreign debt blew a hole on the expenditure side, trade liberalization, ...
OneBeacon Reports $16.69 Adjusted Book Value Per Share
PR Newswire (press release), NY - May 2, 2008
The first quarter of 2008 also included a $59 million reduction in unrealized investment gains in revenues as a result of adopting FASB Statement No. 159. ...OB
Nano-sized technology has super-sized effect on tumors
Washington University Record, MO - Apr 16, 2008
"Many chemotherapeutic drugs have unwanted side effects, and we've shown that our nanoparticle technology has the potential to increase drug effectiveness ...
Expedia Inc Q1 2008 Earnings Call Transcript
Seeking Alpha, NY - May 1, 2008
Do you believe Hotwire is somewhat countercyclical, or is it just that people are looking for a better deal, and on the European side, are you seeing ...EXPE
LETTERS: Mat 2, 2008
North County Times, CA - May 2, 2008
If you find it threatening to be on such a list, maybe you'll have a better understanding of the resistance to gun registration. Yokozuna to DD wrote on May ...
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment ...
RedOrbit, TX - May 3, 2008
Siems W, Wiswedel I, Salerno C, et al. beta-Carotene breakdown products may impair mitochondria! functions-potential side effects of high-dose beta-carotene ...
Source: Google News

Perception of the role and potential side effects of inhaled corticosteroids among asthmatic … -
LP Boulet - Chest, 1998 - Am Coll Chest Phys
... 19 To better understand how to provide adapted and ... such as inhaled corti- costeroids,
and understand their fears ... the role and potential side effects of asthma ...

Therapeutic Approaches to Bone Diseases -
GA Rodan, TJ Martin - Science, 2000 - sciencemag.org
... be manipulated to generate new and even better SERMs. ... antiinflammatory action but
without detrimental effects on bone ... by a carbon with various side chains (Fig ...

Obesity Impact on Cardiovascular Disease -
RM Krauss, M Winston, BJ Fletcher, SM Grundy - Circulation, 1998 - Am Heart Assoc
... from obesity-related consequences may better delineate who ... an important component
in understanding both why ... moderate weight loss and have minimal side effects. ...

Do Parents Understand Immunizations? A National Telephone Survey -
BG Gellin, EW Maibach, EK Marcuse - Pediatrics, 2000 - Am Acad Pediatrics
... regard to concern about side effects for each of ... and to help parents better understand
why physicians ... of parental attitudes and understanding of immunizations ...

Molecular targets for breast cancer therapy and prevention -
J Bange, E Zwick, A Ullrich - Nature Medicine, 2001 - nature.com
... indicated a statistically significant reduction of 49 ... only tumor cells with minimal
side effects for normal ... and, consequently, a better understanding of common ...

[PDF] The neurobiology of pain -
JM Besson - Lancet, 1999 - ub.uio.no
... new analgesics, but also for a better understanding of pain ... to target these systems
could produce widespread side-effects. ... that there can be a reduction in the ...
-

Collaborative Management of Chronic Illness -
M Von Korff, J Gruman, J Schaefer, SJ Curry, EH … - Annals of Internal Medicine, 1997 - annals.highwire.org
... Health care leaders must better understand incentives that are intrinsic ... Families
and health: the negative side of social ties ... S, van den Broek Y. Effects of a ...

Randomized Clinical Trial of an Implantable Drug Delivery System Compared With Comprehensive Medical … -
TJ Smith, PS Staats, T Deer, LJ Stearns, RL Rauck, … - Journal of Clinical Oncology, 2002 - jco.ascopubs.org
... doses were eligible if opioid side effects refractory to ... with at least a 20% reduction
in toxicity ... toxicity were conducted to better understand the differences ...

The impact of patients' preferences on the treatment of atrial fibrillation: observational study of … -
J Protheroe, T Fahey, AA Montgomery, TJ Peters - BMJ: British Medical Journal, 2000 - pubmedcentral.nih.gov
... table 1). The relative risk reduction and the ... utility states (such as severity of
side effects), but this may be at the expense of better understanding for the ...

Integrating response shift into health-related quality of life research: a theoretical model -
MAG Sprangers, CE Schwartz - Social Science & Medicine, 1999 - Elsevier
... the comparatively severe gastro-intestinal side effects of methotrexate ... his or her
health was better, then the ... in model development, our understanding of the ...

Source: Google Scholar

Reduction In Risks And Side Effects From Anaesthetics Likely With Better Understanding Of How Anaesthetics Work
An important clue to how anaesthetics work on the human body has been provided by the discovery of a molecular feature common to both the human brain and the great pond snail nervous system, scientists report. Researchers hope that the discovery of what makes a particular protein in the brain sensitive to anaesthetics could lead to the development of new anaesthetics with fewer side effects.

The study focuses on a particular protein found in neurons in the brain, known as a potassium channel, which stabilises and regulates the voltage across the membrane of the neuron. Communication between the millions of neurons in the brain -- which is the basis of human consciousness and perception, including perception of pain -- involves neurons sending nerve impulses to other neurons. In order for this to happen, the stabilising action of the potassium channel has to be overcome. Earlier studies on great pond snails by the same team identified that anaesthetics seemed to selectively enhance the regulating action of the potassium channel, preventing the neuron from firing at all -- meaning the neuron was effectively anaesthetised.

The new research has identified a specific amino acid in the potassium channel which, when mutated, blocks anaesthetic activation. Lead author, Biophysics Professor Nick Franks from Imperial College London, explains how this will allow the importance of the potassium channel in anaesthetic action to be established:

"We've known for over 20 years now that these potassium channels in the human brain may be important anaesthetic targets.

However, until now, we've had no direct way to test this idea. Because a single mutation can block the effects of anaesthetics on this potassium channel without affecting it in any other way, it could be introduced into mice to see if they also become insensitive to anaesthetics. If they do, then this establishes the channel as a key target."

The group carried out their new study, published in the 20 July issue of the Journal of Biological Chemistry, by cloning the potassium channel from a great pond snail and then making a series of chimeric channels -- part snail and part human.

The chimeras were used to identify the location of the precise amino acid to which the anaesthetic binds on the potassium channel, giving the team a clearer picture than ever before of the precise mechanism by which anaesthetics work.

This kind of research, explains Professor Franks, is important because understanding exactly how anaesthetics work may pave the way for the development of a new generation of anaesthetics which solely affect specific anaesthetic targets, which could potentially reduce the risks and side effects associated with current anaesthetics.

"At the moment, anaesthetics have many unwanted side-effects on the human body such as nausea and effects on the heart. This is because our current drugs are relatively non-selective and bind to several different targets in the body. A better understanding of how anaesthetics exert their desirable effects could lead to much more specific, targeted alternatives being developed, which could greatly reduce these problems," he said.


Source: Danielle Reeves
Imperial College London

 
 
 
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