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Recent News and Articles on the Keywords: thinning drug + blood + computer  Related to the article below (Last Update: 5/19/2008)

Heparin Contaminated on Purpose, Congress Told
Newsinferno.com, NY - Apr 30, 2008
The chemical had been molecularly changed to mimic heparin?s blood thinning properties. That ingredient was supplied to Baxter by Changzhou SPL, ...
Source: Google News

Ginger Lowers Blood Pressure Through Blockade of Voltage-Dependent Calcium Channels. -
MN Ghayur, AH Gilani - Journal of Cardiovascular Pharmacology, 2005 - cardiovascularpharm.com
... of ginger, it may interact with blood-thinning drugs such as ... Blood Pressure in
Anesthetized Rats TOP. ... for 30 minutes before exposing the tissue to any drug. ...

[CITATION] Intravesical Drug Delivery: Pharmacokinetic and Clinical Considerations. -
MS Highley, AT van Oosterom, RA Maes, EA De Bruijn - Clinical Pharmacokinetics, 1999
... bladder can be regarded as a thin diffusion barrier ... gradient, and capillary removal
of drug, which depends on ... difference be- tween tissue and perfusing blood. ...

[PDF] Space-derived Health Aids -
P Implantable - ntrs.nasa.gov
... When the computer reports its medication is ... include programmed metering of
blood-thinning drugs to prevent ... tumors; methadone for drug addiction; antabuse for ...
-

Knowledge of Stroke Risk Factors, Warning Symptoms, and Treatment Among an Australian Urban … -
S Sug Yoon, RF Heller, C Levi, J Wiggers, PE … - Stroke, 2001 - Am Heart Assoc
... conducted a telephone survey using the Computer-Assisted Telephone ... respondents described
"blood clot?dissolving drug or blood-thinning drugs" such as ...

Effect of Blood Viscosity on Oxygen Transport in Residual Stenosed Artery Following Angioplasty -
O Kwon, M Krishnamoorthy, YI Cho, JM Sankovic, RK … - Journal of Biomechanical Engineering, 2008 - link.aip.org
... it is known that anti-blood-thinning drugs (eg, protamine ... on Oxygen Transport to
Blood Flowing in a ... RappitschG., and PerktoldK., 1996, ?Computer Simulation of ...

Heart Insight is lively, upbeat and glossy?but also provides readers with the most up-to-date, … -
A PALKHIVALA - HEART, 2007 - heartinsight.com
... Not taking the blood-thinning drugs often prescribed after a heart ... or whether you
can substitute a drug that treats ... as high cholesterol and high blood pressure ...
-

[CITATION] JUST WHAT THE DOCTOR ORDERED: Taking Your Meds As Prescribed Could Save Your Life
A PALKHIVALA - HEART, 2007

[DOC] Colgan Institute News
K Vitamin - colganinstitute.com
... of Vitamin K, and due to the large portion of the population on blood-thinning drugs
it is not ... The molecular basis of blood coagulation. ... They are not drugs. ...

Aspects of the modification of the self-medication behavior of patients by presentation of …
J Rosiene, X Liu, D Sawyer - Enterprise Networking and Computing in Healthcare Industry, …, 2003 - ieeexplore.ieee.org
... 'Masters Student, Depanment of Computer Science, University of Connecticut, Storrs, ...
?Aspirin can increase the effect of blood thinning drugs, thus increasing ...

Computer game delusions -
R Forsyth, R Harland, T Edwards - Journal of the Royal Society of Medicine, 2001 - Royal Soc Med
... Treatment includes non-steroidal anti-in?ammatory drugs, other analgesia ... Blood tests
were unremarkable. ... in the left frontoparietal cortex and thinning in the ...

Source: Google Scholar

Computer Dosage Calculation Of Blood Thinning Drugs Found To Be Safe
The largest ever study into the administration of blood thinning drugs like Warfarin has concluded that dosages calculated by computer are at least as safe and reliable as those provided by trained medical professionals.

Increasing evidence of the value of these anticoagulant drugs in a wide range of clinical disorders such as abnormal heart rhythm, or atrial fibrillation, has led to a rapid rise in their use around the world.

However, prescribing the right oral dose of anticoagulant to patients, even for experienced medical staff, can be problematic as individuals differ greatly in response to a given dose: too high a dose for an individual and the blood becomes too thin and can lead to internal bleeding, too low and the blood clots too readily.
Previous studies supporting the use of computer-assisted dosage have depended solely on laboratory results and have not been sufficiently large to determine whether observed improvements in normal blood clotting time -- known as the 'international normalised ratio' or INR -- resulted in clinical benefit and improved safety.

But now results from a four-year clinical trial organised from The University of Manchester have shown that computer-assisted dosage is as good, if not better, at prescribing the correct dosage to normalise and maintain the correct INR in patients as dosages given by medical professionals.

"The need for computer assistance arises from the massive demand for oral anticoagulants following their success at treating an increasing number of thrombotic and embolic conditions," said Professor Leon Poller, who headed the research in Manchester's Faculty of Life Sciences.

"This increased demand has been overwhelming and stretched medical facilities worldwide to their limits. Computer dosage was introduced as a way to meet this demand but its safety and effectiveness had never been established."

The study, carried out in 32 medical centres across the European Union and involving more than 13,000 patients, analysed nearly 400,000 INR tests, divided evenly between manual and computer-assisted dosage.

The percentage of manual tests to give the correct INR was 64.7%, compared to 65.9% for computer-assisted dosage, confirming the effectiveness of the two programs tested by the team.

In terms of safety, the number of INR tests that resulted in clinical complications was 7.6% lower in all clinical groups with computer-assisted dosage, dispelling any safety concerns.

Indeed, while this overall figure may not be deemed significant, in the 3,208 patients with deep vain thrombosis or pulmonary embolism, the number of clinical events following treatment were significantly lower for computer dosage -- 9.1 per 100 patient-years with medical staff dosage was reduced to 6.1 in the computer arm.

"The results are even more impressive when you consider that the comparisons were made against medical professionals based at centres that specialised in prescribing oral anticoagulants," said Professor Poller.
"At the very least, our study confirms the clinical safety and effectiveness of computer-assisted dosage using the two systems we tested and should help to bring relief to overstretched medical professionals while providing reassurance to patients."

The 32 centres with a special interest in oral anticoagulation recruited 13,219 patients, providing 18,617 patient-years.

INR tests numbered 193,890 with manual dosage and 193,424 with computer-assistance, giving 'time-in-range' of 64.7% and 65.9% respectively.

The two computer programs tested were PARMA 5 and DAWN AC.

The results of the study have just been presented to the International Society on Thrombosis and Haemostasis conference in Geneva, Switzerland.

Source: Aeron Haworth
University of Manchester
 
 
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