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Recent News and Articles on the Keywords: proteomics research + proteomic research + new  Related to the article below (Last Update: 7/8/2008)

New bioinformatics software created
United Press International -
"This could be a powerful way to improve both genome and proteome annotations and to address notoriously difficult biological problems that remain outside ...
Power3 Medical Products, Inc. Provides Progress Report ? NuroPro ...
Business Wire (press release), CA -
The institute's Cleo Roberts Center for Clinical Research takes laboratory discoveries to clinical trials that foster hope for new treatments. ...OTC:PWRM
GenoLogics Expands Its LIMS Platform With St. George's, University ...
Eworldwire (press release), NJ -
Geneus is based on the same configurable and flexible platform as Proteus, GenoLogics' proteomic data management system. The platform is designed to adapt ...
Manchester scientist appointed new BBSRC boss
University of Manchester, UK -
The University of Manchester?s Professor Douglas Kell has been appointed as the next Chief Executive of the Biotechnology and Biological Sciences Research ...
Undergraduates Forge New Area Of Bioinformatics
Science Daily (press release) - Jul 2, 2008
Jesse Rodriguez, the undergraduate researcher who is now at working on a Ph.D. at Stanford, also published a paper in the Journal of Proteome Research ...
Shared recipes for longer life
Science News - Jul 7, 2008
... with males and when comparing the groups on normal or calorie-restricted diets, the team reports online and in an upcoming Journal of Proteome Research. ...
Illumina to Announce Second Quarter 2008 Financial Results on ...
FOXBusiness -
Our customers include leading genomic research centers, pharmaceutical companies, academic institutions, clinical research organizations, and biotechnology ...ILMN
Medical Lab Receives Grant for Vaccine Research
WNEP-TV, PA - Jul 7, 2008
"We predominantly (do) vaccine development and we do it using the latest technology which is called proteomics," Del Vecchio explained. ...
NJ Biotech Industry Remains Buoyant Despite Broader Life-Sci Slump ...
BioRegion News, NY - Jul 7, 2008
Research, testing, and medical laboratories in New Jersey increased 31.4 percent to 925 between 2001 and 2006. The nation?s growth in this sector was ...
New Center for Sickle Cell Disease
Johns Hopkins Gazette, MD - Jul 7, 2008
For example, a basic-science project led by Allen Everett, a pediatric cardiologist, will use the science of proteomics, the study of proteins, ...
Source: Google News

[BOOK] Proteome Research: New Frontiers in Functional Genomics
MR Wilkins - 1997 - books.google.com
... those who conceived the notion of proteomics and contributed ... stored, retrieved and
applied by the research and industrial ... 1 Proteome: a new word, a new field ...

Use of proteomic patterns in serum to identify ovarian cancer -
EF Petricoin, AM Ardekani, BA Hitt, PJ Levine, VA … - The Lancet, 2002 - Elsevier
... Institutes of Health Office of Human Subjects Research. ... Figure 1. Phases of
N-dimensional proteomic analysis. ... and described herein is Proteome Quest beta ...

The dynamic range of protein expression: a challenge for proteomic research. -
GL Corthals, VC Wasinger, DF Hochstrasser, JC … - Electrophoresis, 2000 - ncbi.nlm.nih.gov
... from the last decade of genomic research as we ... The availability of a "proteomics
toolbox", consisting of ... Proteome. PMID: 10786884 [PubMed - indexed for MEDLINE]

A common open representation of mass spectrometry data and its application to proteomics research -
PGA Pedrioli, JK Eng, R Hubley, M Vogelzang, EW … - Nature Biotechnology, 2004 - nature.com
... applications of MS-based proteomics research: database searching ... data associated
with a proteomics publication in ... at the HUPO Plasma Proteome Project Jamboree ...

[PDF] Proteomics to study genes and genomes -
A Pandey, M Mann - Nature, 2000 - biochem.wisc.edu
... relationship between genes and the protein complement or ?proteome? of a ... Proteomics
to study ... Whitehead Institute for Biomedical Research, Nine Cambridge ...
-

Proteomics: quantitative and physical mapping of cellular proteins -
WP Blackstock, MP Weir - Trends in Biotechnology, 1999 - Elsevier
... transmuted into a new discipline, ?proteomics?, which at least implies that money
should be spent on it! The first book on proteome research has recently ...

The role of separation science in proteomics research -
HJ Issaq - Electrophoresis, 2001 - doi.wiley.com
... the most impor- tant tools in proteomics research for peptide ... possible a new concept
of ?accurate mass tags? that ... on-line to FTICR for proteome analysis of ...

[PDF] From genomics to proteomics -
M Tyers, M Mann - Nature, 2003 - natureasia.com
... has proclaimed five initial goals for world-wide proteomics research: definition
of the plasma proteome, proposals for an in-depth proteomics assault on ...
-

Proteomics: a new approach to the study of disease -
G Chambers, L Lawrie, P Cash, GI Murray - The Journal of Pathology, 2000 - doi.wiley.com
... proteomics represents an exciting new way to ... Proteomics: quantitative and physical
mapping of ... Proteome research: complementarity and limitations with respect ...

Proteomics: new perspectives, new biomedical opportunities -
RE Banks, MJ Dunn, DF Hochstrasser, JC Sanchez, W … - The Lancet, 2000 - Elsevier
... and subsequent identification of new proteins and ... provided from the ExPASy proteomics
server (www ... databases are the bioinformatic core of proteome research. ...

Source: Google Scholar

New Proteomics Research
Human cells function through the concerted action of thousands of proteins that control their growth and differentiation. Yet, the specific function of most human proteins remains either unknown or poorly characterized. Diseases being often due to aberrations in the function of key cellular proteins, numerous large-scale research initiatives have been launched internationally to crack the function of all human proteins. In a research article that will be published in the July 20th issue of the journal Molecular Cell, a research team led by Dr. Benoit Coulombe from the Institut de recherches cliniques de Montreal (IRCM) describes a powerful proteomics approach that promises to have a profound impact on our current understanding of the human proteome and the function of its individual proteins.
"In this work, we have taken advantage of an intrinsic property of proteins in order to develop a method that we use to infer a putative function to many previously uncharacterized proteins", said Dr. Coulombe who is very excited by his team's achievement and the future prospects these efforts hold. The unique property of proteins, exploited by this Montreal research team, is the fact that proteins rarely work alone, but rather assemble with other proteins into complexes to concertedly exert their function. The strategy of the IRCM researchers was basically to identify the interaction partners of many proteins of well-known function, using sophisticated proteomics procedures and computational algorithms they developed. The initial guess of the scientists was that proteins interacting together are likely to be partners in the same biological pathway and, consequently, to serve the same (or related) function(s). By systematically identifying the interaction partners of 32 human proteins known to exert specific functions in gene transcription and RNA processing, the Coulombe team has defined an intricate network of 805 high-confidence interactions that connect together 436 different proteins. Among them, many proteins of previously unknown function can now be inferred putative functions based on their association. To confirm that physically interacting proteins are also functionally related, the researchers have selected a number of the previously uncharacterized proteins present in their network and conducted more detailed functional assays. "The specificity of our procedure to identify functionally relevant interaction partners is amazing", said Dr. Coulombe. "For example, we present in the Molecular Cell article the long-awaited discovery of a cellular enzyme that regulates the stability of small RNA molecules playing pivotal roles in cell function and regulation. The existence and importance of this enzyme was recognized for more than a decade, but it had been so far impossible to isolate it in the sea of proteins that make up human cells and further characterize it. We succeeded in finding the enzyme, which we named MePCE, as an interaction partner of another cellular protein it regulates". Many other important proteins have been uncovered in this analysis and their precise roles in cell function will be published in the coming months and years.

Defining the maps of protein interactions that regulate cell growth, differentiation and disease progression is the overall goal of the Human Proteotheque Initiative (HuPI), a forward-looking project conducted in the Coulombe laboratory. Central to the HuPI project is its experimental platform, termed the "HuPI discovery engine", which ultimately generates maps of protein interaction networks. The Molecular Cell article reports on the first generation of this technology platform that is currently being improved by a multi-disciplinary team of scientists.
What is most important is to develop a highly reliable and efficient discovery pipeline that generates interaction maps that are both as complete and as accurate as possible". Dr. Coulombe likes to compare his HuPI discovery engine to the Google search engine for the Internet. Setting in place a method that generates useless information would be a waste of time and resources. Instead, Coulombe aims to deploy all energy and brain power to build a proteomics discovery pipeline that produces only relevant, useful information (as Google is also efficient to map useful links for a Web search, leaving out most irrelevant information). Given the success seen thus far, Dr. Coulombe may well be on the right road to achieve his long-term objective which is to build a publicly-available repertoire of molecular maps that represents the fingerprint of the physiological status of normal human cells and the signature of some disease conditions. "If this comprehensive repertoire of protein interaction networks, termed the Human Proteotheque, can assist scientists worldwide in identifying important new proteins that can be used to diagnose and/or eventually cure specific diseases, then I will have succeeded in doing what I set out to do", concluded Dr.

Dr. Benoit Coulombe

Reference: Célia Jeronimo, Diane Forget, Annie Bouchard, Qintong Li, Gordon Chua, Christian Poitras, Cynthia Thérien, Dominique Bergeron, Sylvie Bourassa, Jack Greenblatt, Benoit Chabot, Guy G. Poirier, Timothy R. Hughes, Mathieu Blanchette, David H. Price and Benoit Coulombe. (2007) Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular Cell 27, July 20th, 2007 issue.

Benoit Coulombe is director of the Gene Transcription and Proteomics Laboratory and the Proteomics Discovery Platform of the IRCM (Institut de recherches cliniques de Montréal). He is also professor in the Department of Biochemistry of the Université de Montréal. This research is funded by Genome Québec, Genome Canada, the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC).

Established in 1967, the IRCM (http://www.ircm.qc.ca/) is recognized as one of the country's top-performing health research centres. It has a mandate to understand the causes and mechanisms of diseases in order to find diagnostic tools and means of prevention and treatment; to train a new generation of high-level scientists; and to contribute to Québec's socio-economic development by facilitating the commercial development of new discoveries. The IRCM has 37 research units and a staff of more than 450.

Source: Lucette Thériault
Institut de recherches cliniques de Montreal
 
 
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