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Recent News and Articles on the Keywords: link between + work could + mit  Related to the article below (Last Update: 5/12/2008)


The Age
"Everybody talks about the weather but nobody does anything about ...
The Age, Australia - May 10, 2008
But the link between seeding and rainfall is controversial. How do you prove rain was caused by seeding? A 2002 report from the United States National ...
Chance to link campus and community is invaluable
Inverness Courier, UK - May 6, 2008
Perhaps, students could reside in some areas of the Old Town which are crying out to be brought back to life. All around MIT, students and professors alike ...
Scientists Unravel Heparin Death Mystery
Science Daily (press release) - Apr 23, 2008
The New England Journal of Medicine study offers the first potential link between the contaminant and the reported deaths. The researchers found that the ...
Books On Electronics For the Lay Programmer?
Slashdot - May 7, 2008
As for your link to electricity misconceptions [eskimo.com], all I can say is that I find the information there disagrees with what I was taught by the US ...

Adweek
'The Hills' Is Alive
Adweek, NY - May 5, 2008
"Differentiating between the seekers and the generators struck me as a significant," said Rubinson. "What's groundbreaking here is they were able to link ...
Dr. Evelynn Hammonds, Harvard College?s next Deanby
Madison Times, WI - May 2, 2008
She then went to the Massachusetts Institute of Technology (MIT) to earn a master?s degree in physics. While at MIT she realized she was one of only a ...
The Return of Ada
Slashdot - Apr 15, 2008
Ada's stringency causes more work for programmers, but it will also make the code more secure, Ada enthusiasts say. Last fall, contractor Lockheed Martin ...
Bonus Review: Apple's Time Capsule
Washington Post, United States - Apr 29, 2008
But afterwards, it worked the same over a wired or wireless link. (My colleague Liz McGehee, however, wrote that she returned a Time Capsule that wouldn't ...
Riding the College-to-Business School Express
Harvard Crimson, MA - Apr 20, 2008
?We were the link between the teams that ran the funds and the teams that distributed the funds to individual private clients or to institutional investors, ...
A New Transatlantic Agenda in a Changing World
PR Newswire (press release), NY - Apr 14, 2008
There is a strong link between the nuclear powers' willingness to disarm and the willingness of the non-nuclear states not to build up their arsenals. ...
Source: Google News

The link between individual and organizational learning
DH Kim - The Strategic Management of Intellectual Capital, 1993 - books.google.com
... what makes a" good" route home from work. ... The Link between Individual and Organizational
Learning 49 Audienc ... the nature of the environment could change, thus ...

Culture in Action: Symbols and Strategies
A Swidler - American Sociological Review, 1986 - JSTOR
... systematic view of the dynamic interactions between culture and ... One could point to
practical links be- tween ... Choices: How Women Decide about Work, Career, and ...

The control of filamentous differentiation and virulence in fungi -
HD Madhani, GR Fink - Trends in Cell Biology, 1998 - Elsevier
... Recent work has implicated a gene encoding a ... There is an intriguing link between
mating type ... that control dimorphism are conserved between distantly related ...

Work, locales and distributed social worlds -
G Fitzpatrick, WJ Tolone, SM Kaplan - … European Conference on Computer-Supported Cooperative Work, 1995 - portal.acm.org
... can offer particular insights into the link between the social ... point for bridging
the gap between the social ... on Computer-Supported Cooperative Work, Chapel Hill ...

Experiments with Oval: a radically tailorable tool for cooperative work -
TW Malone, KY Lai, C Fry - ACM Transactions on Information Systems (TOIS), 1995 - portal.acm.org
... name to reduce the widespread confusion between Information Lens ... Oval (objects, views,
agents, and links) are not new ... was described in our previous work [Lai et ...

Understanding human competence at work: an interpretative approach
J Sandberg - Academy of Management Journal, 2000 - JSTOR
... of formal educa- tion and length of work experience, but no clear links emerged
between those sources ... Human competence at work: An in- Sandberg, J. 1995 ...

Reflections on NoteCards: seven issues for the next generation of hypermedia systems -
FG Halasz - ACM Journal of Computer Documentation (JCD), 2001 - portal.acm.org
... are in fact icons for traversable links between the browser ... emphasizes versioning
[10] and node/link attri- butes. ... 25] and to single-user work- station systems ...

Sir2 links chromatin silencing, metabolism, and aging -
L Guarente - Genes & Development, 2000 - Cold Spring Harbor Lab
... I will next speculate how the regulation of Sir2 by NAD could represent the link
between caloric intake and ... Subsequent work proved that Sir2 could, in fact ...

The relationship between work and nonwork domains: A review of empirical research
JP Near, RW Rice, RG Hunt - Academy of Management Review, 1980 - JSTOR
... and extra-work domains of life could be better ... Other studies have shown positive
links between job satisfaction and ... type of community in which work- ers live ...

An overview of PCTE and PCTE+ -
G Boudier, F Gallo, R Minot, I Thomas - Proceedings of the third ACM SIGSOFT/SIGPLAN software …, 1989 - portal.acm.org
... area network, in such a way that useful work could still be ... There is no difference
between the creation or manipulation of links between objects on ...

Source: Google Scholar

MIT IDs Link Between Brain Tumor Proteins Work Could Guide Drugs For Especially Aggressive Cancer
MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients.

Glioblastoma multiforme (GBM), the most aggressive brain tumor in adults, strikes about 15,000 people in the United States each year. GBM is currently treated with a combination of surgery, radiation and chemotherapy, but those treatments have proven ineffective. Most patients die within a year.

Now, MIT scientists have uncovered a connection between two proteins found in the tumor cells, and they have demonstrated that attacking both of those proteins kills tumor cells much more effectively than targeting either one alone.
The researchers, led by Forest White, MIT associate professor of biological engineering, report their findings in the early online edition of the Proceedings of the National Academy of Sciences for the week of July 16-20.

Their work could guide drug developers seeking treatments for GBM, which has proven resistant to all drugs that have been tried against it.

The team focused on a protein called EGFRvIII, a mutated form of the cell receptor for epidermal growth factor (EGF). The mutated receptor, which is found in approximately a quarter of GBM tumors, is continuously active and relentlessly pushes cells to keep growing and dividing.

Doctors have tried treating GBM patients with drugs that inhibit EGFRvIII, but they have had little effect. This could be because the continuous stimulation of the receptor is so intense and because the receptor interacts with numerous other proteins that also promote tumor growth, said White, who is also affiliated with MIT's Center for Cancer Research and its Computational and Systems Biology Initiative.
The researchers believe it is the cumulative action of EGFRvIII and those other proteins that leads to tumor growth.

"It seems that it is not the activation of one receptor that results in cancer. It's the action of multiple receptors that leads to the tumors we see," said Paul Huang, a graduate student in biological engineering and lead author of the paper. "A potential way to overcome this is to attack multiple targets instead of just one."

To find out what other proteins are involved in tumor growth, the researchers used a tool known as mass spectrometry to analyze the network of proteins activated by EGFRvIII in GBM tumor cells.

They found that when EGFRvIII is activated, so is another receptor called c-Met. C-Met is normally active during human development, but it's turned off in most adult cells.

Until now, there had been no evidence of any "cross-talk" between c-Met and EGFRvIII in GBM. This discovery could offer an explanation for why GBM tumors are so invasive, because over-activated c-Met has already been implicated in very invasive types of lung and breast cancers.
The researchers don't know yet how EGFRvIII is activating c-Met, and whether other proteins are involved in the activation.

"The mechanism underlying this control has yet to be fully characterized," said White. "Our data shows that as EGFRvIII is activated, c-Met is activated as well. Whether it's direct, or indirect, is something that we are currently deciphering."

The new knowledge of c-Met's involvement could give researchers a potent tool to attack GBM tumors. When the MIT group treated tumor cells with drugs that inhibit EGFRvIII and c-Met, respectively, much lower doses were required to kill the cells than when either drug was given alone.

There are several EGFRvIII inhibitors in clinical trials now, and some have already been approved to treat other cancers. Drug companies are also working on c-Met inhibitors, and Huang estimated that some might be available in five to 10 years.

Other MIT authors on the paper are Ryan Flynn, a sophomore biology major, and Zachary Brewer, a senior chemical engineering major. This work was performed in collaboration with researchers at the Ludwig Institute of Cancer Research (San Diego Branch) led by Webster Cavenee and Frank Furnari. The research was funded by the National Cancer Institute, the National Institutes of Health and the Goldhirsh Foundation.

By Anne Trafton

Massachusetts Institute of Technology
 
 
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