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Recent News and Articles on the Keywords: disease-free mosquitoes + disease-free mosquito + mosquito  Related to the article below (Last Update: 5/5/2008)

Tips for a disease-free summer
Times of India, India - Apr 24, 2008
"This is the time when mosquito breeding starts, so dengue, malaria and other vector-borne diseases make a comeback. Precautions must be taken to stop ...
Source: Google News

Comparative Efficacy of Insect Repellents against Mosquito Bites -
MS Fradin, JF Day - The New England Journal of Medicine, 2002 - nejm.org
... For each test, 10 disease-free, laboratory-reared Aedes aegypti female mosquitoes
that were between 7 and 24 days old were placed into separate laboratory ...
-

An epidemiological model for West Nile virus: invasion analysis and control applications -
MJ Wonham, T de-Camino-Beck, MA Lewis - Proceedings of the Royal Society B: Biological Sciences, 2004 - journals.royalsoc.ac.uk
... Thus, for any given initial density of adult mosquitoes, s m0 , the resulting
disease-free equilibrium (DFE) is (l m0 , s m0 , e m0 , i m0 ) = ( m s m0 /( l ...

[PDF] A mathematical model for endemic malaria with variable human and mosquito populations -
GA Ngwa, WS Shu - Mathematical and Computer Modelling, 2000 - library.ictp.trieste.it
... variable human and mosquito populations is analysed. Conditions are derived
for the existence of endemic and disease free equilibria. A ...
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Influence of vertical and mechanical transmission on the dynamics of dengue disease -
L Esteva, C Vargas - Mathematical Biosciences, 2000 - Elsevier
... where a is the transmission probability from humans to mosquitoes. ... (3.4). We have
the disease-free equilibrium E 0 =(1,0,0,0,0), which always exists in O. ...

… responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito … -
Z Peng, AN Beckett, RJ Engler, DR Hoffman, NL Ott, … - The Journal of Allergy and Clinical Immunology, 2004 - Elsevier
... 29 individuals who lived in Manitoba, Canada, and who had a negative bite test result
from disease-free, laboratory-reared Aedes aegypti mosquitoes; all these ...

Attitudes towards Chagas' disease in an endemic Brazilian community -
S Williams-Blangero, JL VandeBerg, ARL Teixeira - Cadernos de Sa?de P?blica, 1999 - SciELO Brasil
... recover spontaneously from the acute phase and remain seropositive but disease-free
for the ... showed that only 25-50% of residents identified mosquitoes as the ...
-

Multi-state epidemic processes on complex networks -
N Masuda, N Konno - Journal of Theoretical Biology, 2006 - Elsevier
... models in which the phase boundary between the coexistence state, where both
susceptible and infected individuals can survive, and the disease-free state with ...

Pathogens and the evolution of primate sociality
WJ Freeland - Biotropica, 1976 - JSTOR
... The pos- sibility of continually moving into new disease-free environments is
eliminated ... If an animal can reduce the num- ber of mosquitoes by which it is bitten ...

POTENTIAL ROLE OF SYLVATIC AND DOMESTIC AFRICAN MOSQUITO SPECIES IN DENGUE EMERGENCE -
M DIALLO, AA SALL, AC MONCAYO, Y BA, Z FERNANDEZ, … - The American Journal of Tropical Medicine and Hygiene, 2005 - ASTMH
... human travel resulting in DENV introduction into previously disease-free regions,
and an expansion of the range of the principal epidemic mosquito vector Aedes ...

Epstein-Barr virus-associated T-cell lymphoma: a case of eyelid swelling and intramuscular … -
F Shirasaki, K Taniuchi, T Matsushita, Y Hamaguhi, … - British Journal of Dermatology, 2002 - Blackwell Synergy
... fever and high titres of EBV-related antibodies, whereas hypersensitivity to mosquito
bites and ... in our patient, contributing to the 3-year disease-free survival ...

Source: Google Scholar

Disease-Free Mosquitos
A decade ago, scientists announced the ability to introduce foreign genes into the mosquito genome. A year ago, scientists announced the successful use of an artificial gene that prevented a virus from replicating within mosquitoes. But how does one apply what can be done with a small number of mosquitoes in a lab to the tens of millions of mosquitoes that spread disease worldwide"

Researchers from Virginia Tech and the University of California Irvine have demonstrated the ability to express a foreign gene exclusively in the female mosquito germline, a necessary prerequisite to future genetic control strategies in mosquitoes where all progeny of lab and wild mosquitoes will have the gene that blocks virus replication -- or whatever trait has been introduced into the lab mosquitoes.
Until now, if lab-grown mosquitoes that are unable to support virus replication were to mate with wild, disease-vector mosquitoes, only half of their off-spring would have the anti-virus gene. Researchers have been working on how to skew the outcome so that all off-spring lack the ability to spread disease. However, these experiments have been hampered by the inability to express foreign genes in the mosquito germ cells.

"We needed to gain access to the cells in the reproductive germline to change the way traits are inherited," said Zach Adelman, assistant professor of entomology and a member of the Vector-Borne Infectious Disease Research Group at Virginia Tech (http://www.vectorborne.ibphs.vt.edu/).

Adelman discussed what the research breakthrough means for the future control of diseases spread by mosquitoes in his talk, "Dengue Viruses and Mosquitoes, Scourge of the Developing World: Can Genetic Control Make a Difference?" presented at the 2007 Biotechnology Education Conference at the Inn at Virginia Tech, hosted by the Fralin Biotechnology Center at Virginia Tech.

The research appeared in the Proceedings of the National Academy of Sciences (PNAS) http://www.pnas.org/cgi/content/abstract/104/24/9970), in the article, "Nanos gene control DNA mediates developmentally-regulated transposition in the yellow fever mosquito Aedes aegypti," by Adelman, assistant professor of entomology at Virginia Tech, and UC Irvine colleagues Nijole Jasinskiene, Sedef Onal, Jennifer Juhn, Aurora Ashikyan, Michael Salampessy, Todd MacCauley, and Anthony A. James.

Working with Aedes aegypti, the mosquito that carries yellow fever and dengue fever viruses, the researchers are working to create a "gene-drive system" by using instructions copied from the nanos (nos) gene, which is essential for germline formation. "Think of the nanos instructions as a key to a room," Adelman said.

Using the nanos "key," the researcher team successfully achieved germline-specific expression of Mos1, an enzyme isolated from the housefly that is a transposable element (TE) -- a piece of genetic material that moves around. Mos1 can also move anything attached to it and can duplicate itself and whatever is attached to it, such as a gene that directs the dengue virus to stop replication.
"The research reported in PNAS shows that we can access the female germline and we can perform experiments in the germline," said Adelman. "The nanos control sequences show promise as a part of a TE-based gene drive system," he said.

Adelman was also a member of the team that genetically modified Aedes aegypti so that it was resistant to dengue virus type 2 and showed that the virus was unable to replicate. That research, reported in PNAS on March 14, 2006, also took advantage of the Mos1 transformation system. The anti-viral gene was activated in the mosquito gut following a blood meal. The research was a collaboration of researchers at Colorado State University and UC Irvine, lead by Alexander W.E. Franz at Colorado State. Adelman, who joined the Virginia Tech faculty two years ago, was previously at UC Irvine.

Source: Susan Trulove
Virginia Tech
 
 
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