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Recent News and Articles on the Keywords: bladder + scientists + bladders  Related to the article below (Last Update: 7/8/2008)

Pregnancy may protect against bladder cancer, UR study finds
Rochester Democrat and Chronicle, NY - Jul 6, 2008
Traditionally, scientists have blamed men's higher risk of bladder cancer on increased rates of smoking and exposure to certain chemicals in the workplace. ...
Pregnancy May Help Protect Against Bladder Cancer
Science Daily (press release) - Jun 26, 2008
ScienceDaily (June 26, 2008) ? Pregnancy seems to confer some protection against bladder cancer in mice, scientists have found. Female mice that had never ...
Breakthroughs offer hope to MS patients
Tehran Times, Iran - 9 minutes ago
Still another might have slurred speech, tremors, stiffness and bladder problems, according to the National Multiple Sclerosis Society. ...
Flawed Analysis Block Official Release of CDC Study
Mackinac Center for Public Policy, MI -
But a study of the homes of Roto-Finish employees found traces of a suspected bladder carcinogen[16] in vacuum cleaner dust, dryer lint and urine samples. ...
What you should know
Melbourne Herald Sun, Australia - Jul 2, 2008
It's under the bladder and in front of the rectum. The prostate partly surrounds the urethra, the tube that carries urine from the bladder during urination ...

HealthNewsDigest.com
Raw Veggies Fight Cancer, Tests Say
KNBC.com, CA - Jun 17, 2008
Certain vegetables can help protect against bladder cancer if they are eaten raw, according to new research. Scientists at Roswell Park Cancer Institute in ...
Certain Vegetables More Potent Raw Than Cooked - Just Three ... Medical News Today (press release)
all 60 news articles »
Different Type Of Colon Cancer Vaccine Reduces Disease Spread ...
Science Daily (press release) - Jun 24, 2008
... sites might be extended to other cancers that originate from mucosal cells, including cancers of the head and neck, lung, breast, vagina, and bladder. ...
Colon Cancer Vaccine on the Horizon RedOrbit
Study suggests colon cancer vaccine possible Washington Post
all 49 news articles »
In the end, take me to the river
Myrtle Beach Sun News, SC - Jul 5, 2008
But at least I'd be saving some schmuck in the future who'd have a properly trained surgeon when it came time to remove a gall bladder. ...

Natural News.com
The Poisoning of America's Water Supplies
Natural News.com, AZ - Jul 3, 2008
"Individuals who consume chlorinated drinking water have an elevated risk of cancer of the bladder, stomach, pancreas, kidney and rectum as well as ...
Prognostic Significance Of HIF-1α Polymorphisms In Transitional ...
Medical News Today (press release), UK - Jun 15, 2008
A total of 219 patients with bladder cancer and 464 healthy native Japanese control subjects were enrolled. Tissue VEGF and HIF-1 α expression levels and ...
Source: Google News

p53 Immunohistochemistry as a Prognostic Marker in Bladder Cancer Playground for Urology Scientists? -
E Urol - European Urology, 2000 - content.karger.com
Bladder and Urothelial Cancer. p53 Immunohistochemistry as a Prognostic
Marker in Bladder Cancer Playground for Urology Scientists? ...

Bladder Tumors in Rats Fed Cyclohexylamine or High Doses of a Mixture of Cyclamate and Saccharin -
JM Price, CG Biava, BL Oser, EE Vogin, J Steinfeld … - Science, 1970 - sciencemag.org
... 1967, scientists of the FDA reexamined all available information ... Bladder Tumors in
Rats Fed Cyclohexylamine ... cell tumors were found in the urinary bladders ...

… Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary Bladder. -
JI Epstein, MB Amin, VR Reuter, FK Mostofi - The American Journal of Surgical Pathology, 1998 - ajsp.com
... urologists, urologic oncologists, and basic scientists with an ... CIS), the natural
history of bladder dysplasia in ... are typically seen in bladders with urothelial ...

Smooth muscle of the bladder in the normal and the diseased state: Pathophysiology, diagnosis and … -
WH Turner, AF Brading - Pharmacology and Therapeutics, 1997 - Elsevier
... PHARMACOL. THER. 75(2):77-110, 1997. 0 1997 Elsevier Science Inc. KEY WORDS. Urinary
bladder, smooth muscle, diabetic neuropathy, detrusor, unstable bladder. ...

[PDF] Occupational Risks of Bladder Cancer in the United States: I. White Men -
DT Silverman, LI Levin, RN Hoover, P Hartge - jnci, 1989 - jnci.oxfordjournals.org
... blaster and powderman; agricultural scientist; gardener in ... 3). Baggage porters,
biological scientists, and com ... the relationship between bladder cancer risk and ...

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer -
S Sen, H Zhou, RD Zhang, DS Yoon, F Vakar-Lopez, S … - jnci, 2002 - jnci.oxfordjournals.org
... StatSoft, Inc., Tulsa, OK) and Statistical Package for Social Scientists Software
(SPSS ... linked to chromosomal instability and aneuploidy in human bladder cancer ...

Dietary acrylamide and cancer of the large bowel, kidney, and bladder: Absence of an association in … -
LA Mucci, PW Dickman, G Steineck, HO Adami, K … - British Journal of Cancer, 2003 - nature.com
... The relative risk estimates for bladder and kidney cancers were also unaffected
by the ... unexpected, and led to a call by public health scientists for additional ...

Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder -
WA Kachadorian - The Journal of Cell Biology, 1981 - Rockefeller Univ Press
... within the cytoplasm of the granular cells of those bladders in which ... Vasopressin :
induced structural change in toad bladder luminal membrane. Science (Wash ...

Bladder cancer in relation to cigarette smoking -
A Augustine - Cancer Research, 1988 - AACR
... TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced ... 40
years of Philip Morris' efforts to influence a leading scientist J. Epidemiol ...

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? -
MA Knowles - Carcinogenesis, 2006 - Oxford Univ Press
... Similar articles in ISI Web of Science. Similar articles in PubMed. ... REVIEW. Molecular
subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? ...

Source: Google Scholar

Scientists move closer to bio-engineered bladders

Researchers at the University of York are using an understanding of the special cells that line the bladder to develop ways of restoring continence to patients with serious bladder conditions, including cancer. The research, highlighted in the quarterly magazine of the Biotechnology and Biological Sciences Research Council (BBSRC) this week, is looking at urothelial cells. These are the specialised lining cells of the bladder that enable it to retain urine. The cells have a very low turnover rate, but scientists have found that if the bladder is damaged, the urothelial cells are able to rapidly re-grow to repair the wound. The researchers hope to harness this property to engineer new bladders.

The York researchers have developed a series of models that mean they can study human urothelial cells in the laboratory. Of these models, the most important is their development of a urothelial cell sheet that functions as it would in the bladder. When the researchers create a wound in this model, the cells regenerate to repair the damage - just as they would in the body.

Pharmaceutical companies should soon be able to use the research models to test therapies for the bladder, but the longer term aim for this research is to help patients who have lost bladder function or have had all or part of their bladder removed because of cancer.

Research leader, Professor Jenny Southgate, explains: "The models we have developed mean that we have been able to examine how urothelial cells in the bladder self-renew to cope with injury.

"With this basic understanding of how the cells work, we are moving towards being able to engineer new bladders. Currently, substitute bladders can be created by using a section of the patient's bowel, but this can lead to complications, as the bowel does not have the same urine-holding properties as urothelial cells. One solution could be to use laboratory-grown urothelial cells to line a section of bowel."

The hope in the long term is that collaborative research to combine Professor Southgate's work with biomaterial studies at the Universities of Durham and Leeds could mean engineered bladder tissue ready for transplantation.

Professor Southgate, who is Director of the Jack Birch Unit for Molecular Carcinogenesis, in the Department of Biology at the University of York said: "Our most exciting work moving forward is to develop natural and synthetic biomaterials that could be combined with regenerating urothelial cells. This has the potential to produce viable bladder tissue for transplant into patients who need replacement bladders."
The York research highlights the importance of basic biology research in underpinning medical advances. Professor Nigel Brown, BBSRC Director of Science and Technology, commented: "Fundamental bioscience research forms the foundation for much of the medical advances we have today and hope for in the future. We need a solid understanding of how our bodies work and maintain themselves before we can understand what goes wrong when they become diseased and how the disease can be treated."
 
 
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