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Recent News and Articles on the Keywords: cerebrospinal fluid + csf hypocretin-1 + narcolepsy  Related to the article below (Last Update: 5/12/2008)

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Source: Google News

The Role of Cerebrospinal Fluid Hypocretin Measurement in the Diagnosis of Narcolepsy and Other … -
E Mignot, GJ Lammers, B Ripley, M Okun, S … - Archives of Neurology, 2002 - Am Med Assoc
... 24 Human narcolepsy is generally not due to gene ... with undetectable and, more rarely,
elevated hypocretin-1 levels in the cerebrospinal fluid (CSF). ...

Low cerebrospinal fluid hypocretin(orexin) and altered energy homeostasis in human narcolepsy -
S Nishino, B Ripley, S Overeem, S Nevsimalova, GJ … - Annals of Neurology, 2001 - doi.wiley.com
... was emphasized by preliminary cerebrospinal fluid (CSF) and brain ... study, we found
that CSF hypocretin-1 levels were ... 9 sporadic cases of narcolepsy?cataplexy. ...

Hypocretin (orexin) deficiency in human narcolepsy -
S Nishino, B Ripley, S Overeem, GJ Lammers, E … - The Lancet, 2000 - Elsevier
... hypocretin was measured in the cerebrospinal fluid (CSF) of nine ... by a physician
experienced with narcolepsy (GJL). ... Hypocretin-1 was extracted from 1 mL of CSF ...

… (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and … -
LE Krahn, VS Pankratz, L Oliver, BF Boeve, MH … - Sleep, 2002 - ncbi.nlm.nih.gov
... orexin) levels in cerebrospinal fluid of patients ... The relationship between
hypocretin-1 levels and ... This study compared cerebrospinal (CSF) hypocretin-1 in 13 ...

CSF hypocretin-1(orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic … -
T KANBAYASHI, Y INOUE, S CHIBA, R AIZAWA, Y SAITO, … - Journal of Sleep Research, 2002 - ingentaconnect.com
... SUMMARY We measured cerebrospinal fluid (CSF) hypocretin-1 levels in 11 patients
with narcolepsy?cataplexy, five with narcolepsy without cataplexy and 12 ...

CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and … -
Y Dauvilliers, CR Baumann, B Carlander, M Bischof, … - British Medical Journal, 2003 - jnnp.bmj.com
... CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without ...
Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low ...

… borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 ( … -
C Bassetti, M Gugger, M Bischof, J Mathis, C … - Sleep Medicine, 2003 - Elsevier
... markers of narcolepsy with cataplexy (classical narcolepsy) include sleep ... DQB1*0602
positivity, low levels of cerebrospinal fluid (CSF) hypocretin-1 (orexin A ...

Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed … -
RM Salomon, B Ripley, JS Kennedy, B Johnson, D … - Biological Psychiatry, 2003 - Elsevier
... so we examined lumbar cerebrospinal fluid (CSF) hypocretin-1 levels in ... in that our
opening fluid samples were ... Lower CSF hypocretin levels (hypocretin-1 levels ...

Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis -
S Overeem, J Dalmau, L Bataller, S Nishino, E … - Neurology, 2004 - AAN Enterprises
... The authors measured CSF hypocretin-1 levels in six ... excessive daytime sleepiness;
hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an ...

Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic … -
JE Mart?nez-Rodr?guez, L Lin, A Iranzo, D Genis, … - Sleep, 2003 - ncbi.nlm.nih.gov
... Since narcolepsy is characterized by a dysfunction of the hypothalamic ... Cerebrospinal
fluid hypocretin-1 levels were measured using a direct radioimmunoassay in ...

Source: Google Scholar

Persons with narcolepsy with cataplexy have low levels of CSF hypocretin-1

WESTCHESTER, Ill. -- Persons with narcolepsy with cataplexy have low levels of cerebrospinal fluid (CSF) hypocretin-1, a protein thought to help regulate sleep and wakefulness, according to a study published in the August 1st issue of the journal SLEEP.

The study, authored by Mona Skard Heier, MD, PhD, of Ullevål University Hospital in Oslo, Norway, focused on 64 previously diagnosed patients: 47 with narcolepsy with cataplexy, seven with narcolepsy without cataplexy and 10 with idiopathic central nervous system (CNS) hypersomnia, a condition characterized by recurrent daytime sleepiness without the abrupt sleep attacks classically seen in narcolepsy. The patients answered a questionnaire that asked about sleep habits, daytime sleepiness, accessory symptoms, duration and treatment.

Low hypocretin-1 values were found in 72 percent of those patients with narcolepsy and cataplexy. Patients with low CSF hypocretin-1 levels reported more extensive muscular involvement during cataplectic attacks than patients with normal levels.

Patients with narcolepsy without cataplexy and idiopathic CNS hypersomnia all had normal hypocretin-1 levels. No significant clinical or biochemical differences were found between these patient groups.

“Although hypnagogic hallucinations and sleep paralysis were most frequently reported by patients with narcolepsy with cataplexy than in the other patient groups, there was no correlation to low hypocretin-1 values,” said Heier. “Hypnagogic hallucinations and sleep paralysis are usually thought to be isolated components of REM sleep in the waking state. Similarly, cataplexy has been considered as an isolated manifestation of REM sleep atonia, triggered by emotional stimuli.”

Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes features of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy.

About one out of every 2,000 people is known to have narcolepsy. The chance that you have narcolepsy is higher when a relative also has it. It is very rare for more than two people in the same family to have this sleep disorder. It affects the same number of men and women.

Those who suspect they might be suffering from narcolepsy, or another sleep disorder, are urged to consult with their primary care doctor or a sleep specialist.
 
 
 
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