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Recent News and Articles on the Keywords: lyme disease + life cycle + interrupting  Related to the article below (Last Update: 5/5/2008)

Diagnosis and Treatment of Lyme Disease
RedOrbit, TX - May 3, 2008
Reported cases of Lyme disease in the United States by year, 1991-2005. From the Centers for Disease Control and Prevention.1 FIGURE 3. Two-year life cycle ...
Common Sense Control of Insect Pests on Homestead Animals
Mother Earth News, KS - May 2, 2008
Ticks, where they come from and how they spread Rocky Mountain spotted fever and Lyme disease.... Follow this vet's advice for a flea-free summer, ...
How to prevent Lyme disease
Culpeper Star Exponent, VA - Apr 27, 2008
First, many pet owners do not understand the timing of the deer tick life cycle. These ticks generally spend the summer months as tiny, immature stages. ...
Cancer survivors praise Regional Cancer Center
Reporter-Times, IN - May 3, 2008
I was tested for every disease known to man, including Crohn?s disease, Rocky Mountain spotted fever and Lyme disease. I had to give a complete history of ...
RICK CHARMOLI | CADILLAC NEWS
Cadillac News,  United States - May 1, 2008
... that shows the life cycle of a deer tick in his office in Cadillac. Wilson said that while Lyme Disease is in Michigan he believes it is not widespread. ...
Letters: Languages and Lyme
Philadelphia Inquirer, PA - Apr 27, 2008
However, he scoffs at the "Lyme literate" approach to treating Lyme disease. In addition, he questions the quality of research that supports long-term ...
NEW FOOD FACTS
Mother Earth News, KS - May 2, 2008
Here are just a few items from the food front (as well as the latest update on Lyme disease), as reported by the editors of American Health, a magazine that ...
German Tots Learn to Answer Call of Nature
Wall Street Journal - Apr 13, 2008
Frankfurt resident Donna Parssinen sent her son to a Waldkindergarten last year but says he got Lyme disease from ticks. It resulted in meningitis that ...
The Human Side of Global Warming
Center For American Progress, DC - Apr 10, 2008
In the United States, viruses such as West Nile, Hantavirus, and Lyme disease could increase their ranges or spread more quickly with changing weather, ...
Source: Google News

Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody 1 -
U Pal, RR Montgomery, D Lusitani, P Voet, V … - The Journal of Immunology, 2001 - Am Assoc Immnol
... in mice and humans and serves as a Lyme disease vaccine (15 ... prevent tick colonization
by B. burgdorferi, and therefore interrupt the spirochete life cycle. ...

Lyme borreliosis -
CL Fritz, AM Kjemtrup - Journal of the American Veterinary Medical Association, 2003 - Am Vet Med Assoc
... ticks con- tribute to complex life cycles for ... In 1982, the Centers for Disease Control
and Prevention (CDC) initiated surveillance for Lyme bor- reliosis ...

OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected … -
J Tsao, AG Barbour, CJ Luke, E Fikrig, D Fish - Vector Borne and Zoonotic Diseases, 2001 - liebertonline.com
... of wild reservoirs and interrupting the enzootic ... scapu- laris: fluctuations during
the tick life cycle. ... specific transmission-blocking Lyme disease vaccine. ...

The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within … -
X Li, U Pal, N Ramamoorthi, X Liu, DC Desrosiers, … - Molecular Microbiology, 2007 - Blackwell Synergy
... survival in nature may lead to new strategies to interrupt the spirochaete life
cycle, and thereby reduce the abundance of the Lyme disease agent in the ...

Dynamic Changes in Borrelia burgdorferi Populations in Ixodes scapularis (Acari: Ixodidae) during … -
J Piesman, NS Zeidner, BS Schneider - Vector-Borne and Zoonotic Diseases, 2003 - liebertonline.com
... of novel ways of interrupting the spread ... an arthropod-specific transmission blocking
Lyme disease vaccine ... burgdorferigene expression during life cycle phases of ...

Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes … -
G Neelakanta, X Li, U Pal, X Liu, DS Beck, K … - PLoS Pathog, 2007 - pathogens.plosjournals.org
... its vector might lead to new ideas for combating the Lyme disease. ... a basis for the
development of novel strategies to interrupt the spirochete life cycle. ...

[PDF] Developing an integrated approach for diagnosing, managing tick-borne diseases
S Levy - DVM Magazine, 2002 - dvmnewsmagazine.com
... Table 2: Tick life cycle and Lyme disease ... individu- als are possibly infected for
life.New re ... however,the long incubation for canine Lyme disease may allow for ...

Attempt to Control Ticks (Acari: Ixodidae) on Deer on an Isolated Island Using Ivermectin-Treated … -
PW Rand, EH Lacombe, MS Holman, C Lubelczyk, RP … - Journal of Medical Entomology, 2000 - bioone.org
... represent a particularly effective method of interrupting the life cycle of the ... an
extensively studied offshore island where Lyme disease was hyperendemic ...

[CITATION] TELECONNECTIONS OF THE EL NINO PHENOMENON: PUBLIC HEALTH AND EPIDEMIOLOGICAL PROSPECTS
R Woodruff, C Guest - El Nino: Studies from the Asia-Pacific Region, 2000 - The White Horse Press

Strategies for primary and secondary prevention of Lyme disease -
KM Corapi, MI White, CB Phillips, LH Daltroy, NA … - NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007 - nature.com
... The life cycle of the tick vector is known ... Lyme disease might also be avoided by
the ... All the preventive behaviors described interrupt Lyme disease transmission ...

Source: Google Scholar

Interrupting The Lyme Disease Life Cycle

Blocking a tick protein that protects the Lyme disease bacteria as it moves from mice back to the tick that infected them might reduce incidences of the illness among humans, a Yale School of Medicine researcher reports in Cell Host & Microbe.

Lyme disease, which is transmitted to people by deer ticks, is the most common tick-borne illness in the United States. The primary reservoirs for its bacteria, known as Borrelia burgdorferi, are mice, chipmunks, and other small rodents. Symptoms include a skin rash, abnormal heart rhythms, arthritis, and meningitis.
In this study on mice, Erol Fikrig, professor of internal medicine, first blocked the protein Salp25D in the tick's salivary gland to see if it would interrupt transmission of the bacteria, but it did not affect the bacteria.

The ticks engorge on humans and other vertebrates for several days, penetrating the skin, damaging vessels, and obtaining blood from the resulting bruise. In response, neutrophils and other inflammatory cells are recruited to the bite site to disrupt tick feeding. Ticks counteract these forces with an assortment of immunomodulators, anticoagulants, and other biologically active proteins in saliva.

Fikrig then found that the tick must secrete the protective Salp25D into the bite site in order for the Lyme disease agent to successfully migrate from mice to ticks. The tick acquires the pathogen from the host it infected-in this case, mice.

"Developing Salp25D-based strategies to interrupt the Borrelia burgdorferi life cycle may lead to new methods of reducing the incidence of Lyme disease," he said.

Fikrig said the control and prevention of many insect-borne diseases has been primarily focused on trying to produce antibodies to fight the infection. The emphasis is now shifting to disrupting the insects' life cycle.

The research was supported by grants from the National Institutes of Health.

Cell Host & Microbe 2: 7-18 (July 12, 2007)

http://www.yale.edu
 
 
 
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