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Recent News and Articles on the Keywords: duke university + july 30 + 2007  Related to the article below (Last Update: 5/5/2008)

Prep notebook: Cline takes over boys team at Madisonville
Princeton Times Leader, KY - May 3, 2008
Duke and numerous other schools have also shown interest. Hood, who figures to be among the frontrunners for Mr. Basketball 2009, puts the Maroons among the ...
Unwelcome Guest: PBDEs in Indoor Dust
Food Consumer, IL - May 1, 2008
Research published by Webster and colleagues in the 1 July 2007 issue of Environmental Science & Technology also found high levels of PBDEs in air from ...
ENTERTAINMENT NOTES : Piano quintet, poetry lecture, Pinocchio on ...
Arkansas Democrat Gazette, AR - Apr 27, 2008
Exploring Yeats Stanford University professor Eavan Boland will examine the works of Irish poet WB Yeats at 6: 30 pm Thursday in the Darragh Center of the ...
International League News & Notes- 05.01
OurSports Central (press release), WI - May 1, 2008
As a freshman at Duke University in 2000 he went 1-1 with a 4.68 ERA in his only season as a pitcher. The Clippers also used a pitcher to pinch-hit on ...
Sports Briefs: Bishop McGuinness grad Britz is named commissioner ...
Winston-Salem Journal, NC - May 2, 2008
He will replace Doug Echols, who is retiring after 19 years, and will start work in July, becoming only the second full-time commissioner in SAC history. ...
Bernanke Grapples With Greenspan as Volcker Scorns Fed Bailouts
Bloomberg - Apr 21, 2008
``He is very even-keeled, with a pleasant demeanor, a level temperament,'' says Richard Newell, an economist at Duke University who studied under Bernanke ...
Seekonk native a leader of the pack
Attleboro Sun Chronicle, MA - Apr 20, 2008
For the 2003 graduate of Duke University, backpacking has become his preferred means of connecting with the natural world that both enlivens and humbles him ...
Fairfield County Calendar
The Stamford Times, CT - Apr 23, 2008
Music with DJ Lee Moore "The Duke of Doo Wop." No cover. VFW Post 603 holds a dance every Friday with music from the '40s, '50s and '60s. ...
Philharmonic quintet performs for 'Music on Main' series
Durham News, NC - Apr 11, 2008
Joe Robinson, former principal oboist of the New York Philharmonic and now artist in residence at Duke University, describes the quintet as "the finest ...
Community Notes (April 25)
Allston-Brighton TAB, MA - Apr 24, 2008
?AAA? teams have a maximum roster of 60 players, and single ?A? teams have a maximum roster of 30 players. Games begin in July for ?AAA? and in August for ...
Source: Google News

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology -
… -Pierrat, D Abramowski, M Duke, KH Wiederhold, C … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... Pierrat * , , Dorothee Abramowski * , , Mairead Duke * , , Karl-Heinz ... and ? Institute
for Pathology, University of Basel ... mice by phenserine PNAS, July 24, 2007 ...

Yeast microarrays for genome wide parallel genetic and gene expression analysis -
DA Lashkari, JL DeRisi, JH McCusker, AF Namath, C … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... CA 94305; and ? Department of Microbiology, Duke University, Durham, NC ... Biol., July
15, 2003; 23(14): 4814 - 4825. ... Acids Res., October 15, 2002; 30(20): e104 ...

Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion -
XJ Chen, LW Hedlund, HE Moller, MS Chawla, RR … - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences
... C/O Elaine G. Fitzsimons, Center for In Vivo Microscopy, Duke University Medical
Center ... E-mail: egf{at}orion.mc.duke.edu ... J. Anaesth., July 1, 2003; 91(1): 16 - 30 ...

Static and dynamic lengths of neutrophil microvilli -
JY Shao, HP Ting-Beall, RM Hochmuth - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
... of Mechanical Engineering and Materials Science, Duke University, Durham, NC ... e-mail:
hochmuth{at}acpub.duke.edu ... cytoskeleton adhesion J. Cell Sci., July 1, 2007 ...

Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy -
RB Vega, BA Rothermel, CJ Weinheimer, A Kovacs, RH … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... MO 63110; and ? Office of the Dean, Duke University School of ... an inhibitor of
calcineurin PNAS, October 30, 2007; 104(44 ... Res., July 7, 2006; 99(1): 15 - 24. ...

Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral … -
MJ Lindberg, L Tibell, M Oliveberg - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... Edited by Irwin Fridovich, Duke University Medical Center, Durham, NC ... and familial
amyotrophic lateral sclerosis PNAS, July 24, 2007; 104(30): 12524 - 12529 ...

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs -
R Yi, Y Qin, IG Macara, BR Cullen - Genes & Development, 2003 - Cold Spring Harbor Lab
... 3 nM of the [ 32 P]-pre-miR-30 probe, and ... G?rlich (ZMBH, Heidelberg, Germany), James
Dahlberg (University of Wisconsin ... E-MAIL culle002{at}mc.duke.edu; FAX (919 ...

Biomass and toxicity responses of poison ivy (Toxicodendron radicans) to elevated atmospheric CO2 -
JE Mohan, LH Ziska, WH Schlesinger, RB Thomas, RC … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences
... M. El Sohly (University of Mississippi, University, MS) for ... at}oeb.harvard.edu or
schlesin{at}duke.edu. ... Atmospheric Carbon Dioxide Crop Sci., July 30, 2007; 47(4 ...

Superoxide accelerates DNA damage by elevating free-iron levels -
K Keyer, JA Imlay - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences
... Communicated by Irwin Fridovich, Duke University Medical School, Durham, NC ... Chem.,
January 12, 2007; 282(2): 929 - 937 ... Chem., May 30, 2003; 278(23): 20708 - 20715 ...

Profound neuronal plasticity in response to inactivation of the dopamine transporter -
SR Jones, RR Gainetdinov, M Jaber, B Giros, RM … - Proceedings of the National Academy of Sciences - National Acad Sciences
... Hughes Medical Institute Laboratories, Box 3287, Duke University Medical Center ...
e-mail: caron002{at}mc.duke.edu. ... Chem., July 18, 2003; 278(30): 28089 - 28100. ...

Source: Google Scholar

Two-Drug Combo Tough on Kidney Cancer

Early trial shows promise for interferon, sorafenib together

 

(SOURCE: Duke University, news release, July 30, 2007)

TUESDAY, July 31 (HealthDay News) -- Kidney cancer might have met its match in a new combination of cancer drugs, a new study shows.

Used together, interferon alpha, a drug that boosts the body's ability to fight off tumors and infections, and sorafenib, a drug that cuts off a tumor's blood supply, led to significant tumor shrinkage in 33 percent of patients in a U.S. pilot study.

"We found that by combining a drug that enlists the immune system's help in combating cancer with one that cuts off a tumor's blood supply, we could substantially increase patients' response rates to treatment," lead investigator Dr. Jared Gollob, of the Duke Comprehensive Cancer Center in Durham, N.C., said in a prepared statement.

Used alone, each drug is only successful in fighting 5 percent to 10 percent of tumors. But the new study finds that the combination works much better. Sorafenib is sold under the brand name Nexavar.

The drugs had an additional benefit, the researchers said, in that the combo therapy doubled the time before tumors began to grow again. According to Gollob, most tumors begin growing again after about five or six months when treated by either drug alone.

Reporting in the Aug. 1 issue of the Journal of Clinical Oncology, Gollob and his research team gave 40 study patients sorafenib in pill form twice daily and interferon alpha injections three time a week for eight weeks. If the patient's tumor had not grown or had shrunk after eight weeks, they repeated the cycle after a two-week break until the tumors disappeared or the cancer got worse. The researchers monitored the tumors using computerized-tomography (CT) scans.

The approach completely destroyed tumors in two of the 40 patients.

Researchers plan to begin a multi-site clinical trial that will analyze the impact of giving patients increasing doses of sorafenib alone after their tumors have shrunk as much as possible on the combination treatment.

According to the U.S. National Cancer Institute, about 51,000 people suffer from kidney cancer every year, and almost 13,000 will die from the disease. The majority of patients are men over the age of 45. The cancer is especially deadly, because it very rarely causes symptoms until it has reached an advanced stage. By the time kidney cancer rates stage IV status, it has spread to other organs such as lungs, liver and bones. People are given six months to two years to live once they reach stage IV, and only about 10 percent are alive five years after diagnosis.

The Duke team noted that one of the biggest challenges facing doctors and patients with kidney cancer is the cancer's resistance to chemotherapy, radiation and other common cancer-fighting tools.

More information

To learn more about kidney cancer visit the U.S. National Cancer Institute

 
 
 
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