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Recent News and Articles on the Keywords: rheumatoid arthritis + slow arthritis + arthritis  Related to the article below (Last Update: 5/12/2008)

Arthritis walk planned: Local event set as chairwoman will be ...
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RTT News - TheStreet.com
all 51 news articles »  BIIB - DNA
Source: Google News

… bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease … -
B M?nsson, D Carey, M Alini, M Ionescu, LC … - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov
... Copyright notice. Cartilage and bone metabolism in rheumatoid arthritis. Differences
between rapid and slow progression of disease identified by serum markers ...

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis -
JM Bathon, RW Martin, RM Fleischmann, JR Tesser, … - New England Journal of Medicine, 2000 - content.nejm.org
... trials and long-term observational studies that disease-modifying anti-rheumatic
drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 ...

Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis -
EHS Choy, GS Panayi - New England Journal of Medicine, 2001 - content.nejm.org
... rheumatoid arthritis averages $5,919 per case per year in the United States 3 and
approximately ?2,600 per case per year in the United Kingdom. 4 Current slow- ...

Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective … -
F Wolfe, DJ Hawley, MA Cathey - J Rheumatol, 1990 - ncbi.nlm.nih.gov
1990 Aug;17(8):994-1002. Termination of slow acting antirheumatic therapy in rheumatoid
arthritis: a 14-year prospective evaluation of 1017 consecutive starts. ...

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS -
M Feldmann, FM Brennan, RN Maini - Annual Reviews in Immunology, 1996 - Annual Reviews
... ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS. ... This led to the hypothesis that TNFa was
of major importance in rheumatoid arthritis and was a therapeutic target. ...

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist -
B Bresnihan, JM Alvaro-Gracia, M Cobby, M Doherty, … - Arthritis & Rheumatism, 1998 - doi.wiley.com
... American College ol Rheumatvlvgy TREATMENT OF RHEUMATOID ARTHRITIS WITH
RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST BARRY ...

Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development … -
DM van der Heijde, MA van't Hof, PL van Riel, LA … - British Medical Journal, 1990 - ard.bmj.com
... a prospective study of up to three years' duration of 113 patients with early
rheumatoid arthritis. Decisions to start treatment with slow acting antirheumatic ...

Evolving concepts of rheumatoid arthritis -
GS Firestein - Nature, 2003 - nature.com
... T-cell activation could operate within the rheumatoid synovium ... clearly show that
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[PDF] Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind … -
P Emery, H Zeidler, TK Kvien, M Guslandi, R Naudin … - Lancet, 1999 - medwriter.4t.com
... Rheumatoid arthritis (RA) is a chronic, systemic disease characterised by periods
of ... diclofenac SR 75 mg (Voltarol ? 75 slow-release, Ciba-Geigy, UK). ...

Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein … -
JM Kremer, R Westhovens, M Leon, E Di Giorgio, R … - The New England Journal of Medicine, 2003 - nejm.org
... macrophage is an important pathogenic mediator in rheumatoid arthritis, and cytokines ...
block TNF- decrease joint inflammation and slow radiographic progression. ...
-

Source: Google Scholar

Nicotine may slow progression of rheumatoid arthritis

Last Updated: 2007-07-31 13:19:24 -0400 (Reuters Health)

By Joene Hendry

NEW YORK (Reuters Health) - In people with rheumatoid arthritis, heavy cigarette smoking appears to slow the rate of joint destruction, new research suggests.

"Potentially, this may be due to the anti-inflammatory properties of nicotine," Dr. Axel Finckh, University Hospital of Geneva, Switzerland told Reuters Health.

Cigarette smoking is a known risk factor for rheumatoid arthritis, a chronic inflammatory disease that causes progressive joint destruction, disability, and premature death, Finckh and colleagues reported in the Annals of the Rheumatic Diseases.

Yet, it remains unclear if smoking influences the progressive joint destruction and disability cause by rheumatoid arthritis. Finckh and colleagues therefore assessed joint X-rays and results from self-reported functional disability questionnaires for more than 2,000 rheumatoid arthritis patients in their early- to mid-fifties.

Most of the patients (1459) did not smoke; 489 were considered moderate smokers and 55 were classified as heavy smokers, consuming more than one pack per day.

Overall, the investigators found that the smokers and non-smokers had similar rates of progressive joint damage and functional disability.

Unexpectedly, they also found slower rates of progressive joint damage in the X-rays of heavy cigarette smokers compared with the moderate smokers and the non-smokers over the 3-year study.

These findings suggest that smoking is more influential in the development of rheumatoid arthritis than the progression of the disease over time, but further research is needed to fully understand the impact smoking has on disease progression.

Still, Finckh cautioned: "The cardiovascular hazards of smoking certainly outweigh the potential anti-inflammatory benefits of nicotine," so the health risks associated with smoking are much greater than any benefits people with rheumatoid arthritis may gain from smoking.

Additional study is needed to understand the influence of tobacco and nicotine on the body's immune system.

SOURCE: Annals of the Rheumatic Diseases, July 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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