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Recent News and Articles on the Keywords: fragile skin + screening tests + skin  Related to the article below (Last Update: 5/12/2008)

What is epidermolysis bullosa?
Daily News Tribune, MA - Apr 15, 2008
When the anchoring mechanism fails, the skin layers slip easily one over the other, making the skin very fragile. Blisters and sores caused by the friction ...
Have you completed your child checklist?
Nashua Telegraph, NH - May 3, 2008
"That wouldn't be good for the kids' skin, would it?" Despite my editor's inside-the-box thinking, with apologies to the dermatologists of the world and to ...
Pathophysiology of Anemia and Nursing Care Implications
RedOrbit, TX - Apr 30, 2008
It is recognized most often when laboratory screening tests are done because individuals often do not present with the signs and symptoms of advanced anemia ...
Source: Google News

Regular review: Diagnosis and management of porphyria -
H Thadani, A Deacon, T Peters - BMJ: British Medical Journal, 2000 - pubmedcentral.nih.gov
... Routine laboratory screening tests may be unreliable, 14 but a recently introduced
screening kit seems ... are similar and include fragile skin that heals ...

THE PORPHYRIAS -
G DEAN - British Medical Bulletin, 1969 - British Council
... no clinical manifestations; latent cases nC Skin fragile or lesions ... variegata, the
tendency for the skin to abrade ... and is the simplest screening test, but it ...

The Neonatal Skin Risk Assessment Scale for Predicting Skin Breakdown in Neonates -
B Huffines, MC Logsdon - Issues in Comprehensive Pediatric Nursing, 1997 - informaworld.com
... care practices that affect the fragile, underdeveloped skin ... significant differ- ences
by T tests in the ... scores of participants who developed skin breakdown and ...

Hydroxylysine-deficient skin collagen in a patient with a form of the Ehlers-Danlos syndrome -
M SUSSMAN - The Journal of Bone and Joint Surgery, 1974 - JBJS
... fragile, and bruisable skin), these patients had severe ... Screening for abnormal urinary ...
He had hyperextensible joints, soft stretchable skin, and scoliosis. ...

Acromegaly and hyperadrenocorticism in cats: A clinical perspective -
EC Feldman, RW Nelson - Journal of Feline Medicine and Surgery, 2000 - Elsevier
... infected and easily bruised skin (?feline fragile skin syndrome ... potbelly (pendulous
abdomen with hepatomegaly) and pigmented skin. ... Diagnosis?screening tests ...

Anaesthesia and severe skin disease -
GB SMITH, AJ SHRIBMAN - Anaesthesia, 1984 - Blackwell Synergy
... extent of skin lesions and the presence of bruising, intra-oral lesions and
pathological fractures should be noted. Tests should include a clotting screen and ...

ACP Best Practice No 165: Front line tests for the investigation of suspected porphyria -
AC Deacon, GH Elder - British Medical Journal, 2001 - jcp.bmj.com
... with acute photosensitivity unaccompanied by fragile skin or bullae. ... lesions in areas
of skin exposed to ... Qualitative screening tests in which the PBG?Ehrlich ...

Endocrinopathies and the skin. -
SA Jabbour, JL Miller - International Journal of Dermatology, 2000 - pt.wkhealth.com
... hormone (TSH) level, which is the most cost-effective screening test.30 In ... of the
hand and the elbow.45 The skin eventually becomes fragile and, in ...

Sensitive skin: a complex and multifactorial syndrome -
A Pons-Guiraud - Journal of Cosmetic Dermatology, 2004 - Blackwell Synergy
... these cases, patch testing can be done using screening series and ... for an ?allergic?
pathology, makes the skin increasingly fragile, subject to ...

Noninvasive Test for Fragile X Syndrome, Using Hair Root Analysis -
R Willemsen, B Anar, YDD Otero, BBA de Vries, Y … - The American Journal of Human Genetics, 1999 - Elsevier
... illustrated by the identification of two fragile X patients ... In contrast, both neurons
and skin develop from the ... test might be ideal to screen populations of ...

Source: Google Scholar

Screen test for fragile skin

White Dorper breeders and owners are hoping to eradicate a genetic disorder causing a lethal fragile skin condition among some of their drought-hardy flocks.

The disease dermatosparaxis also exists in other breeds but White Dorper breeders are the first to opt for a mass flock screening program in Australia.

"Their early adoption of a newly developed test should ensure this disease is effectively managed," NSW DPI research scientist, Dr Tracey Berg, said.

Dermatosparaxis is an inherited connective tissue disorder attributable to abnormal collagen in the skin which causes extreme skin fragility. Normal collagen provides elasticity and strength.

Dermatosparaxis most often affects lambs. They suffer tearing of the skin, usually in their inner thighs and under armpits. The severity of the condition results in death or euthanasia.

Attempts to stitch the skin usually fall apart, exacerbated when animals are handled to check the repair. Mild forms of the disease have been seen in adult sheep.

"If unchecked now, there could be a potential problem for the sheep industry in the future," Angus McTaggart, federal board president of the Dorper Sheep Breeders Society of Australia, said.

The disease has been reported elsewhere in Merino, South African White Dorper and Border Leicester-Southdown sheep.

Similar conditions occur in cattle, cats and humans (Ehlers- Danlos Syndrome type VIIC).

After Brendon O’Rourke and Dr Berg confirmed and defined the disorder in Australian White Dorper flocks at the Elizabeth Macarthur Agricultural Institute (EMAI) at Camden in 2006, they then developed a DNA test to screen individual sheep for the defective gene.

They developed the test in mid-2006 at the request of breeder Malcolm Green with subsequent support from the Breeders’ Society.

"The mutation exists in sheep from most of the Australian flocks we’ve tested," Dr Berg said.

"Of the substantial number of sheep tested, 20 per cent were carriers.

"We have also received overseas submissions and detected carriers from several countries, so it is a world wide problem."

Dr Berg and her colleagues at EMAI are consequently recommending screening of all breeding stock, or at the very minimum, screening of all sires.

"The latter is the first step in managing both damage to reputations and economic loss," former head of the Regional Veterinary Laboratory at EMAI, Dr Keith Walker, said.

"The DNA test provides an avenue for genetically smarter breeding programs."

The breed society is taking advantage of reduced rate testing by being responsible for administering samples, invoicing and reporting results.

It will also note all results on its stud book registration records, to enable public scrutiny of both positive and negative pedigree discrimination by all breeders.

A number of cattle breed societies have embraced this approach, to reduce the incidence of genetic disorders. The new genetic test is available commercially from the Genetics laboratory at EMAI.

Contact Dr Rod Reece, Camden, (02) 4640 6309, for veterinary advice about the disease, or Ian Marsh, (02) 4640 6502, about testing. 

- Ron Aggs
 
 
 
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