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Recent News and Articles on the Keywords: side effects + fat deposits + fat  Related to the article below (Last Update: 5/12/2008)

Safety fears rise over unlicensed 'flab jab'
Independent, UK - May 3, 2008
But safety experts warn there is no reliable evidence about how it works or the long-term effects on fat and other cells. The UK's two main medical insurers ...

PR Web (press release)
Liposuction verses Lipo Dissolving Procedures - This Truth Could ...
PR Web (press release), WA - Apr 25, 2008
With these procedures, chemical agents are injected directly into fat deposits which are supposed to eliminate fat cells - all with minimal downtime and ...
Delirium With Psychotic Features Possibly Associated With Mesotherapy
Psychosomatics (subscription) - Apr 30, 2008
The most common chemical used for treatment of localized fat deposits is phosphatidylcholine. 2 Other formulations may include carnitine, hyaluronidase, ...
Mainstream Docs Join Anti-Aging Bandwagon
NBC6.net, FL - Apr 21, 2008
Besides exercising five days a week and following a strict low-fat diet that includes lots of fruits, vegetables and wild salmon but no white flour or red ...
British Judge Bruises Al Gore?s Movie
New York Times Blogs, NY - Apr 21, 2008
Doctors don?t tell you to wait to see if you get fat before you try eating healthier or exercising more. You do these things voluntarily because they?re ...
How America Can Survive the Rise of the Rest
Foreign Affairs Magazine - Apr 23, 2008
Ultimately, this is what sets the country apart from the experience of Britain and all other past great economic powers that have grown fat and lazy and ...
Source: Google News

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin. -
A Fukuhara, M Matsuda, M Nishizawa, K Segawa, M … - Obstetrical & Gynecological Survey, 2005 - obgynsurvey.com
... because the majority of women did not experience side effects of hot ... on biopsies
of visible lesions included vascular proliferation, deposits of hemosiderin ...

[PDF] Phosphatidylcholine in the treatment of localized fat -
D Hexsel, M Serra, R Mazzuco, T Dal?Forno, D … - J Drugs Dermatol, 2003 - mesotherapyworldwide.com
... of the use of 250 mg/ml phosphatidylcholine injections in the treatment of subcutaneous
fat deposits, showing the clinical response and side-effects. ...
-

Detergent Effects of Sodium Deoxycholate Are a Major Feature of an Injectable Phosphatidylcholine … -
AM Rotunda, H Suzuki, RL Moy, MS Kolodney - Dermatologic Surgery, 2004 - Blackwell Synergy
... these detergent substances into tissue other than fat could lead ... of serious immediate
or long-term adverse effects. 1?3,10 Side effects are transient and self ...

[PDF] Medicinal strategies in the treatment of obesity -
GA Bray, LA Tartaglia - Nature, 2000 - facmed.unam.mx
... antiobesity therapy. However, side effects of Xenical resulting from faecal
fat loss can be a problem for some patients. Another approach ...
-

Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1- … -
PWG Mallon, J Miller, DA Cooper, A Carr - AIDS, 2003 - aidsonline.com
... calculi, one secondary to paronychia and one secondary to other side effects). ... these
subjects already have high baseline body fat deposits, thus explaining the ...

Cellularity of rat adipose tissue: effects of growth, starvation, and obesity -
J Hirsch, PW Han - The Journal of Lipid Research, 1969 - ASBMB
... into four observations from the right side and four ... 5 and 6 show the effects of this
procedure on ... can be accounted for by massive increases in fat deposits. ...

[PDF] Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes -
K Ashrafi, FY Chang, JL Watts, AG Fraser, RS … - Nature, 2003 - ucsf.edu
... and was similar to the pattern of fat deposits previously observed ... potently and
specifically affect fat storage without obvious side-effects on the ...
-

Superficial Fascial System (SFS) of the Trunk and Extremities: A New Concept. -
TE Lockwood - Plastic and Reconstructive Surgery, 1991 - plasreconsurg.com
... deposit is due lo pseudo-fat deposit deformity. ... The excursion of the skin-fat-
superficial fascial ... improved lift with fewer untoward side effects and incisional ...

Impact of Treatment of Dyslipidemia on Renal Function, Fat Deposits and Scarring in Patients with … -
OA Gheith, MAK Sobh, KES Mohamed, MA El-Baz, F El- … - Logo, 2002 - content.karger.com
... The degree of hypertension and manifestations of statin side effects, mainly myopathy ...
There was a significant regression in fat deposits in the statin-treated ...

[CITATION] Long-Term Results of Fat Transplantation: Clinical and Histologic Studies. -
I Niechajev - Plastic and Reconstructive Surgery, 1994
... the dimples and waves that occur as undesirable side effects of lipo ... Transplantation
Fat grafts were preferably obtained from localized fat deposit areas with a ...

Source: Google Scholar

Protein Accumulation Might Cause Fat Deposits, Other Side Effects In HIV-Positive People Taking Protease Inhibitors, Study Says

Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published Monday in the Proceedings of the National Academy of Sciences, Reuters reports. Protease inhibitors can cause metabolic complications -- such as an unhealthy accumulation of cholesterol in the blood, high blood pressure and an increased risk of diabetes -- Reuters reports. The drugs also can cause a condition called lipodystrophy -- an abnormal redistribution of body fat that gives some HIV-positive people gaunt cheeks and limbs, as well as an accumulation of fat on the back of the neck.
Study Findings
For the study, researchers at the University of California-Los Angeles and Purdue University treated mouse and human cells with protease inhibitors and found that they accumulated a clumpy form of the protein prelamin A. According to the researchers, the drug triggered the development of this protein by blocking the action of another protein, called ZMPSTE24, that converts prelamin A into its effective form. According to the study, cells with lower levels of ZMPSTE24 were particularly affected by protease inhibitors.

Christine Hrycyna, a researcher from Purdue University who worked on the study, said that blocking ZMPSTE24 might contribute to the metabolic side effects of protease inhibitors. She also said that people with early aging syndromes, including Hutchinson-Gilford progeria, have symptoms that imitate the side effects associated with protease inhibitors. According to Hrycyna, prelamin A accumulates in the cells of people with early aging syndromes, but she added that the effect on metabolism is not clear. "The side effects are probably due not to just one simple thing," she said.

Charles Flexner of Johns Hopkins University School of Medicine, who was not involved with the study, said that the side effects of protease inhibitors occur among tens of thousands of HIV-positive people worldwide and that the study's findings might "provide new insights into possible mechanisms" of the drugs.

The researchers also tested some of the drugs that are used in highly active antiretroviral therapy and found that they did not trigger the same protein accumulation, even though they have the ability to cause similar side effects. "They are probably due to a combination of all these different drugs," Hrycyna said. According to Reuters, the researchers plan to conduct further studies among humans, as well as investigate if versions of protease inhibitors that block ZMPSTE24 to a lesser extent cause fewer side effects (Ganguli, Reuters, 7/17).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.
 
 
 
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