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Recent News and Articles on the Keywords: genetic link + premenstrual depression + depression  Related to the article below (Last Update: 5/19/2008)


TopNews
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The expansion of the project enables the Korea NIH to increase the overall genetic power of the project to validate previous findings and to identify new ...AFFX
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Source: Google News

Hormones and depression: what are the facts about premenstrual syndrome, menopause, and hormone … -
TB Pearlstein - Am J Obstet Gynecol, 1995 - pt.wkhealth.com
... Genetic and environmental factors in the aetiology of menstrual ... waveform of plasma
nocturnal melatonin secretion in premenstrual depression. ... [Context Link]. 31. ...

Genetic risk factors for major depression in men and women: similar or different heritabilities and … -
KS KENDLER, CO GARDNER, MC NEALE, CA PRESCOTT - Psychological Medicine, 2001 - pt.wkhealth.com
... Genetic and environmental factors in the aetiology of menstrual, premenstrual and
neurotic symptoms: a population ... [Context Link]. Kendler, KS, Neale, MC ...

Childhood and Adolescent Depression: A Review of the Past 10 Years. Part I. -
B Birmaher, ND Ryan, DE Williamson, DA Brent, J … - Journal of the American Academy of Child & Adolescent …, 1996 - jaacap.com
... Seasonal affective disorder, atypical depression, and premenstrual dysphoric disorder ...
at least in part, under genetic influence (Plomin ... Context Link]. 2. Akiskal ...

… Chronic Fatigue Syndrome, Migraine, Irritable Bowel Syndrome, Atypical Facial Pain, and Premenstrual … -
AJ Gruber, JI Hudson, HG Pope - Psychiatric Clinics of North America, 1996 - Elsevier
... bowel syndrome, atypical facial pain, or premenstrual dysphoric disorder ... relevant
regardless of any possible link between these disorders and depression. ...

The Flinders Sensitive Line rats, a genetic model of depression, show abnormal serotonin receptor … -
MK ?sterlund, DH Overstreet, YL Hurd - Molecular Brain Research, 1999 - Elsevier
... Depressive disorders such as premenstrual syndrome, postnatal ... in the FSL rats, a
genetic animal model ... In considering the link between affective disorders and ...

Pubertal changes in hormone levels and depression in girls. -
A ANGOLD, EJ COSTELLO, A ERKANLI, CM WORTHMAN - Psychological Medicine, 1999 - pt.wkhealth.com
... The Premenstrual Syndrome - A Reappraisal of the Concept and the Evidence. ... Journal
of Genetic Psychology 149, 29-34. [Context Link]. Goji, K. (1993). ...

Depression in women -
RE Noble - Metabolism, 2005 - Elsevier
... yet poorly understood factors such as genetic vulnerability and ... or imbalance in specific
premenstrual syndromes and ... Abstract | Full Text + Links | PDF (1005 K ...

Genetic influences on post-natal depressive symptoms: findings from an Australian twin sample. -
SA TRELOAR, NG MARTIN, KK BUCHOLZ, PAF MADDEN, AC … - Psychological Medicine, 1999 - pt.wkhealth.com
... Genetic and environmental factors in the actiology of menstrual, premenstrual and
neurotic symptoms -a population-based twin study. ... [Context Link]. 30. ...

Recognition of depression in obstetric/gynecology practices. Symposium--Women And Depression -
KA Yonkers, SJ Chantilis - American Journal of Obstetrics & Gynecology, 1995 - pt.wkhealth.com
... Genetic and environmental factors in the etiology of menstrual, premenstrual ... [Context
Link]. 33 ... Yonkers KA, White K. Premenstrual exacerbation of depression: one ...

Genetic and environmental influences on premenstrual symptoms in an Australian twin sample. -
SA TRELOAR, AC HEATH, NG MARTIN - Psychological Medicine, 2002 - pt.wkhealth.com
... intakes and improves the mood of women with premenstrual depression. ... [Context Link].
Bucholz, KK, Cadoret ... psychiatric interview for use in genetic linkage studies ...

Source: Google Scholar

Genetic Link To Premenstrual Depression
A specific genetic variation may be tied to an increased risk for severe premenstrual depression, scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health have found.

Known medically as premenstrual dysphoric disorder, or PMDD, this psychiatric condition affects roughly 8 percent of women in their childbearing years. It's characterized by bouts of major depression and/or anxiety and severe irritability during the second half of the menstrual cycle. Symptoms subside with the onset of each menstrual period.
While PMDD has been thought to be linked to hormonal changes over the course of the menstrual cycle, until now an explanation for the susceptibility to hormone-related mood changes has been elusive. "Our initial hope in the study was that by looking at steroid-related genes like those for receptors for steroid hormones such as estrogen, we would be able to find gene differences that might explain why some women have these mood disorders and others don't," said Dr. David R. Rubinow, the study's senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine. "This study may begin to provide important clues to the nature of that susceptibility."

The study is the first to identify a genetic variation linked to a mood disorder associated with endocrine changes during the menstrual cycle, Rubinow said. The results will appear in an upcoming print edition of the journal Biological Psychiatry and were published online June 30, 2007. The study was supported by funds from the Intramural Research Program at the National Institute of Mental Health (NIMH).

The research involved 91 women for whom the authors prospectively confirmed a diagnosis of PMDD over at least three months. Another 56 women who had no history of mood disorders related to the menstrual cycle served as a comparison group. All the women provided blood samples for genetic analysis.

The team discovered four specific genetic variants, called single nucleotide polymorphisms, in one of the two genes that encode the estrogen receptor. The variants, which are differences in strings of DNA nucleotides A, G, C, or T, were identified in the estrogen receptor alpha gene, ESR1.

Compared to the control group, women with PMDD were significantly more likely to have the ESR1 gene variants, the study found.

"While these are preliminary findings that require replication in larger studies, we would argue that this may explain part of the variance among women in the susceptibility to developing this mood disorder," Rubinow said. "Studies have shown that PMDD is characterized by abnormal sensitivity to reproductive steroids like estrogen. As a receptor for the hormone that can trigger the onset of PMDD symptoms, ESR1 has clear physiologic relevance for this disorder."
The authors acknowledge that as with other complex genetic disorders, the contribution to PMDD of polymorphisms in a single gene may not be large. In addition, they also noted that the findings may be telling us more about the control group.

These women, who have no history of psychiatric problems or menstrual cycle-related symptoms, may have gene variants that protect against PMDD. According to Rubinow, "this is equally interesting because it may help us to understand resilience and protection, which are also very important."

Dr. Susan S. Girdler, professor of psychiatry and director of the UNC Psychiatry Stress and Health Research Program, pointed out that the severity of PMDD symptoms are as great or can be as great as those of women with full-blown major depression or major anxiety disorder. "But what makes them different is that the symptoms are very time-limited and linked strongly with the women's menstrual cycle."

Girdler emphasizes that to qualify for PMDD, symptoms must be severe enough to interfere with everyday functioning - to disrupt relationships, result in social withdrawal, even prompt thoughts of suicide. "We are talking about women who meet very stringent diagnostic criteria for PMDD. This is not the garden variety PMS."

Rubinow's coauthors were from the National Institute of Mental Health's Behavioral Endocrinology Branch and Program on Genes, Cognition and Psychosis.

The UNC Center for Women's Mood Disorders is conducting follow-up studies on the genetic and environmental contributors to PMDD. Eligible women will receive free diagnostic and medical evaluations, and may be eligible to take part in reatment studies or studies providing monetary compensation.

Source: Les Lang
University of North Carolina School of Medicine
 
 
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