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Recent News and Articles on the Keywords: 0.21 + ulcer + buruli  Related to the article below (Last Update: 8/5/2008)

Distribution of Arsenic in coals with special to Jharkhand State ...
American Chronicle, CA - Aug 2, 2008
Concentrations of arsenic in Chinese coals are between 0.21 and 32000 ppm . In general, the arsenic content of most Canadian coals is low as compared with ...
Source: Google News

Heterogeneity of Mycolactones Produced by Clinical Isolates of Mycobacterium ulcerans: Implications … -
A Mve-Obiang, RE Lee, F Portaels, PLC Small - Infection and Immunity, 2003 - iai.highwire.org
... of pathology distant from the site of bacterial colonization in Buruli ulcer provided
the ... of a slightly more polar lipid species with an R f value of 0.21. ...

Curing Mycobacterium ulcerans Infection in Mice with a Combination of Rifampin-Streptomycin or … -
S Lefran?ois, J Robert, A Chauffour, B Ji, V … - Antimicrobial Agents and Chemotherapy, 2007 - Am Soc Microbiol
... Strain Cu001 was isolated from a patient with Buruli ulcer in C?te d'Ivoire and ... numbers
of AFB and CFU were 6.45 ? 0.37 and 5.94 ? 0.21, respectively, for ...

Activities of Several Antimicrobials against Mycobacterium ulcerans Infection in Mice -
H Dega, J Robert, P Bonnafous, V Jarlier, J … - Antimicrobial Agents and Chemotherapy, 2000 - pubmedcentral.nih.gov
... been inoculated with material from a Buruli ulcer excised from ... AFB) harvested from
the skin ulcer were inoculated ... was 0.14 (CI 95 , 0.08 to 0.21), suggesting a ...

[PDF] Multivariate Markovian Modeling of Tuberculosis: Forecast for the United States -
SM Debanne, RA Bielefeld, GM Cauthen, TM Daniel, … - Lyme Disease Tuberculosis Vaccines, 2000 - 0-www.cdc.gov.mill1.sjlibrary.org
... 0.13 32.1 237.9 Washington 0.11 25.7 231.9 West Virginia 0.21 39.1 189.4 ... 2,
March?April 2000 Research Buruli ulcer (BU) disease, caused by Mycobacterium ...
-

[PDF] A needs-based pharmaceutical R&D agenda for neglected diseases -
E Torreele, M Usdin, P Chirac - Working draft, 2004 - who.int
... which represent a significant health burden and cause enormous suffering- such as
Buruli ulcer. ... tropical diseases, giving an NCE per DALY ratio of 0.21 1 . Thus ...

Proceedings of the Australasian Society for Human Biology -
A Options, TOC Latest - Annals of Human Biology, 2000 - ingentaconnect.com
... Both Bairnsdale ulcer and Buruli ulcer are caused by the same bacterial species ... that
for the Old World (0.84), but is much higher than that for America (0.21). ...

Proceedings of the Australasian Society for Human Biology
T Huckle - Annals of Human Biology, 2000 - informaworld.com
... Both Bairnsdale ulcer and Buruli ulcer are caused by the same bacterial species ... that
for the Old World (0.84), but is much higher than that for America (0.21). ...

The unusual macrocycle forming thioesterase of mycolactone
JL Meier, T Barrows-Yano, TL Foley, CL Wike, MD … - Molecular BioSystems, 2008 - rsc.org
... and analgesic properties, which result in the unusual painless nature of Buruli
ulcer lesions. ... MLSA2 ACP-TE, 0.33 ? 0.02, 1.63 ? 0.21, 0.20, . ...
-

Total synthesis of mycolactones A and B -
F Song, S Fidanze, AB Benowitz, Y Kishi - Tetrahedron, 2007 - Elsevier
... Graphical abstract. Keywords: Mycolactones; Total synthesis; Buruli ulcer. ... Buruli
ulcer is a severe necrotizing skin disease caused by Mycobacterium ulcerans. ...

Natural antimycobacterial metabolites: current status -
AL Okunade, MPF Elvin-Lewis, WH Lewis - Phytochemistry, 2004 - Elsevier
... disease, tuberculosis, and two skin diseases, leprosy (M. leprae) and buruli ulcer
(M. ulcerans). ... The IC 90 for M. aurum A+ obtained using 23 (0.21 ?g/mL) is ...

Source: Google Scholar

Grant To Develop Test For Buruli Ulcer, A Major African Disease
A new grant from the National Institutes of Health will help researchers at Atom Sciences and the University of Tennessee better understand how people in rural Africa contract a deadly disease known as Buruli ulcer.

The grant from the National Institute of Allergy and Infectious Disease (NIAID) to Atom Sciences will enable the company, in partnership with UT, to test a new diagnostic technique to determine how a person might have acquired the disease from the environment around them.
Prominent in West Africa, the disease resembles leprosy, causing a skin lesion that can lead to infections so severe that limbs may simply fall off, and that the body is unable to fight. The disease is particularly difficult to cure without removing the infected area from the person's body.

Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. The disease itself is not contagious; infected persons acquire the bacteria from their environment. Atom Sciences' new diagnostic technique may allow researchers to know where a person first acquired the bacteria.

Atom Sciences researcher Richard Hurt will lead the study, working with UT microbiology professor Pamela Small. Small, a leading expert in the study of Buruli ulcer, will provide a number of samples for use in testing the new technique.

The diagnostic relies on a genetic analysis of the bacteria. Hurt and Small will compare test results with different strains of the bacteria to refine the diagnostic's ability to detect the subtle genetic differences between bacteria that come from different environmental sources, such as contaminated water sources.

By understanding the sources, medical professionals and researchers will be better able to understand how people acquire the disease, which is known in some areas of Africa as "wounds that do not heal," according to Small.

As the bacteria progresses, it produces toxins that suppress the immune system, eventually destroying skin and underlying tissue. The World Health Organization has said finding the source of this disease is one of the two most important research priorities in its Global Buruli Ulcer Initiative.

The grant, for more than $98,000 during a six-month period, will serve as a pilot test of the new diagnostic technique. As the technique is refined, it also will be adapted to detect other important pathogens.


Source: Jay Mayfield
University of Tennessee at Knoxville
 
 
 
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