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Recent News and Articles on the Keywords: new + researchers + diagnosis  Related to the article below (Last Update: 7/1/2008)


BBC News
Low HDL Linked To Memory Loss
CBS News, NY -
Low levels of high-density lipoprotein (HDL), or good cholesterol, in middle age may increase the risk for developing dementia later in life, new research ...
Low Levels Of Good Cholesterol Linked To Memory Loss, Dementia Risk Science Daily (press release)
Good Cholesterol Linked to Good Memory, British Study Finds Bloomberg
'Good' cholesterol dementia risk BBC News
United Press International
all 83 news articles »
New DNA-Based Test To Detect Drug-Resistant TB In Two Days
AHN -
With the new test, diagnosis and treatment of MDR-TB is expected to increase to 15 percent or more within four years. The test costs $5 but an additional ...
New combination of tests measures child's ability to taste and smell
EurekAlert (press release), DC -
With the development of such a test, physicians can now consider chemosensory dysfunctions in a diagnosis. The loss of taste and smell can be caused by a ...
New 'everyday cognition' scale tracks how older adults function in ...
EurekAlert (press release), DC -
This sensitivity could help with differential diagnosis of underlying brain disease. Because the ECog is sensitive to early functional problems, ...

UCSF Today
New UCSF Program Provides Link Between Basic and Clinical Sciences ...
UCSF Today, CA -
The new program will eventually include two-week mini-courses, symposia and a website that will highlight areas of disease research that could benefit from ...

MSN India
Heavy Birthweight Increases Risk Of Developing Rheumatoid Arthritis
Science Daily (press release) -
Also excluded were women who reported having rheumatoid arthritis or connective tissue disease during follow-up, but in whom the diagnosis could not be ...
Arthritis risk and birthweight NHS Choices
Females With High Birth Weight More Likely To Develop Rheumatoid ... Medical News Today
all 56 news articles »
Montreal Heart Institute and Mount Sinai Hospital researchers ...
Eureka! Science News, Canada -
Twenty-one new genetic risk factors associated with Crohn's disease have been discovered, more than doubling the amount of genetic information about the ...
Honey Bee Gene Expression Altered By Mite Parasitism
GenomeWeb News (subscription), NY -
By Andrea Anderson NEW YORK (GenomeWeb News ) ? New research is revealing the genetics underpinning honey bees? response to Varroa destructor parasitism ...
GE Medical Imaging Technology to Aid Early Diagnosis of All ...
Business Wire (press release), CA -
The first program is a cardiac clinical research study, led by Dr. Malissa Wood at Massachusetts General Hospital in Boston, where researchers are ...GE
Organ Donation: An Advancing Science Hindered by Supply Shortages
U.S. News & World Report, DC - Jun 29, 2008
And that's why the new research -- in which patients can be taken off the anti-rejection drugs -- is important, said Sachs, who heads one of the research ...
Source: Google News

Machine Learning -
T Mitchell, B Buchanan, G DeJong, T Dietterich, P … - Annual Reviews in Computer Science, 1990 - Annual Reviews
... in many impor- tant domains (eg robotics, equipment diagnosis). ... An additional aim
of research is to extend the ... on inductive inference to produce a new round of ...

[BOOK] The New Production of Knowledge: The Dynamics of Science and Research in Contemporary Societies -
M Gibbons - 1994 - books.google.com
... British Library Cataloguing in Publication Data Gibbons, Michael New Production
of Knowledge: Dynamics of Science and Research in Contemporary Societies I. ...

Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes -
L Dixon - Schizophrenia Research, 1999 - Elsevier
... Homelessness and dual diagnosis. Am. ... Poster presented at: New Research Poster Session,
150th Annual Meeting of the American Psychiatric Association, 18?21 May ...

[CITATION] The creation of momentum for change through the process of strategic issue diagnosis -
JE Dutton, RB Duncan - Strategic Management Journal, 1987
... are processed answers the call for new, process- oriented ... begins with the activation
of diagnosis, ie the ... from a wide range of research endeavors including ...

[BOOK] Proteome Research: New Frontiers in Functional Genomics
MR Wilkins - 1997 - books.google.com
... 5 Data analysis and automatic diagnosis 206 8.7. ... Sydney NSW 2 109 Australia; Wool
Research Organisation ofNew ... WRONZ), Private Bag 4749, Christchurch New Zealand ...

[CITATION] Diagnosis of dementia in individuals with intellectual disability* -
EH Aylward, DB Burt, LU Thorpe, F Lai, A Dalton - Journal of Intellectual Disability Research, 1997 - Blackwell Synergy
... Oxford University Press, New York. ... Journal ofMental Deficiency Research 32, 153-62. ...
(1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS ...

Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the … -
… , A Scottsdale, M Boston, C New Haven, C San … - J Am Acad Dermatol, 2002 - rosacea-research.org
... Standard criteria for diagnosis and classifica- tion of ... of basic, clinical, and other
researchers; practicing dermatologists ... and expanded as new discoveries are ...

… smears: A metaanalysis of prospective studies comparing cytologic diagnosis and sample adequacy. -
SJ Bernstein, L Sanchez-Ramos, B Ndubisi - American Journal of Obstetrics & Gynecology, 2001 - pt.wkhealth.com
... Day N. Statistical methods in cancer research: the analysis ... universal adoption of
a new technology with ... sample adequacy and the increased diagnosis of squamous ...

Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. -
S Levenstein, C Prantera, V Varvo, ML Scribano, E … - J Psychosom Res, 1993 - ncbi.nlm.nih.gov
J Psychosom Res. 1993 Jan;37(1):19-32. Click here to read Development of the Perceived
Stress Questionnaire: a new tool for psychosomatic research. ...

Research Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies -
OL Lopez, JT Becker, DI Kaufer, RL Hamilton, RA … - Archives of Neurology, 2002 - Am Med Assoc
... of clinical criteria for the diagnosis of dementia with Lewy bodies (DLBs) presents
new opportunities and challenges for clinicians and researchers alike. ...

Source: Google Scholar

Purdue-IU Researchers Explore New Method For Early Disease Diagnosis
Purdue University researchers worked with the Indiana University School of Medicine to establish a technique that provides a new approach for detecting a number of genetic disorders found in infants and young children.

Daniel Raftery, a Purdue professor of analytical and physical chemistry, and his collaborators used a simple chemical reaction to improve the ability to detect important molecules in complex fluids like blood and urine. The technique makes the markers for some genetically caused metabolic disorders up to 100 times more visible, Raftery said.
"This technique allows us to profile a class of biomarkers - molecules that indicate disease - that would otherwise be very difficult to detect," he said. "The increased sensitivity could allow doctors to diagnose a range of diseases at very early stages. We examined genetically based metabolic disorders, or inborn errors of metabolism, because it is especially important that they be treated early in a child's life in order to prevent tragic effects such as brain damage. The technique also could catch borderline cases that may have otherwise gone undiagnosed until serious symptoms arose."

Bryan Hainline, director of the clinical division of the Department of Medical and Molecular Genetics and clinical associate professor in the metabolism division of the Department of Pediatrics at Indiana University School of Medicine, provided access to clinical samples and insight into the markers of metabolic disorders. The IU team was critical to the success of this work, Raftery said.

"The combination of Purdue's research strength in chemistry and the IU School of Medicine team's knowledge of pediatric metabolic disorders allowed us to quickly advance this technology," he said. "We were able to evaluate the accuracy of the technique by testing it on samples known to contain certain concentrations of various markers."

This method of analysis, called metabolomics, involves the simultaneous analysis of multiple small molecules, or metabolites, which occur in fluids and tissues in the body. The presence of a particular metabolite, grouping of metabolites or ratio of metabolites can indicate a response to biological stress or a specific disease state.

"The metabolic profile in biofluids, such as blood and urine, provides a snapshot of ongoing biological processes in the human body," Raftery said. "This type of analysis could be a key to earlier detection of diseases. Metabolic analysis is currently being developed to identify diseases such as cancer and cardiovascular disease. However, we need to continue to work to refine and improve the techniques to provide early detection."

Raftery and his team used nuclear magnetic resonance spectroscopy, a cousin of magnetic resonance imaging, which provides a reproducible and quantitative measure that provides the broadest spectrum of molecules for metabolite profiling. The spectrum is represented by a pattern of peaks corresponding to different frequencies that can be used to identify the molecules like amino acids in biofluids. Each metabolite has a unique pattern of peaks.
Researchers use nuclear magnetic resonance to detect hydrogen or carbon atoms to provide insight into the metabolites present, however this standard approach has disadvantages, Raftery said. The signals from carbon atoms are very weak and are difficult to detect, while the signals from hydrogen atoms often overlap. In particular, metabolites present in high concentrations overlap those present in low concentrations.

Raftery and his team enhanced the visibility of a certain type of metabolites, amino acids, by chemically tagging the molecules of interest so that they are more easily visible.

"We added a chemical that reacts with the amino acids and similar metabolites and forms a tag that can be seen through nuclear magnetic resonance," he said. "The tag actually is an easily identifiable isotope, in this case a carbon atom that is heavier than the standard carbon atom. Because we can easily detect this isotope, it causes these tagged metabolites to effectively pop out against the background of all of the others."

In addition to Raftery and Hainline, Narasimhamurthy Shanaiah, M. Aruni Desilva, G. A. Nagana Gowda and Michael A. Raftery, all from Purdue's Department of Chemistry, co-authored a paper detailing this research that was published in the July 10 issue of the Proceedings of the National Academy of Sciences.

In addition to its increased sensitivity, the new testing method requires little pretreatment of the sample and roughly 0.5 milliliters of blood to perform the test. The entire test can be performed in about half an hour, providing a quick turnaround for results and treatment decisions for patients, Raftery said.

"It is a very simple process and would not require much training to perform the tests," he said. "It is an easily reproducible test that can be done over and over again, which is important to ensure accurate diagnosis."

Raftery said he plans to continue to work with the IU School of Medicine to perform additional tests on clinical samples, to look at more samples from borderline cases and to examine other diseases.

"This approach is applicable to a variety of molecule types and other fluids, and has the potential for additional applications," Raftery said. "We plan to test more samples and to determine if this methodology proves to be sensitive to cancer and heart disease, as it is for metabolic disorders. We also plan to try other sample types such as tissue."

The National Institutes of Health funded this research in addition to a collaborative biomedical research grant from Purdue University's Discovery Park and the Indiana University School of Medicine.

Abstract

"Class selection of amino acid metabolites in body fluids using chemical derivatization and their enhanced 13-C NMR"
Narasimhamurthy Shanaiah, M. Aruni Desilva, G.A. Nagana Gowda, Michael A. Raftery, Bryan E. Hainline, and Daniel Raftery

We report a chemical derivatization method that selects a class of metabolites from a complex mixture and enhances their detection by 13-C NMR. Acetylation of amines directly in aqueous medium with 1,1'-13-C2 acetic anhydride is a simple method that creates a high sensitivity and quantitative label in complex biofluids with minimal sample pretreatment. Detection using either 1D or 2D 13-C NMR experiments produces highly resolved spectra with improved sensitivity. Experiments to identify and compare amino acids and related metabolites in normal human urine and serum samples as well as in urine from patients with the inborn errors of metabolism tyrosinemia type II, argininosuccinic aciduria, homocystinuria, and phenylketonuria demonstrate the method. The use of metabolite derivatization and 13C NMR spectroscopy produces data suitable for metabolite profiling analysis of biofluids on a time scale that allows routine use. Extension of this approach to enhance the NMR detection of other classes of metabolites has also been accomplished. The improved detection of low-concentration metabolites shown here creates opportunities to improve the understanding of the biological processes and develop improved disease detection methodologies.

http://www.purdue.edu
 
 
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