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Recent News and Articles on the Keywords: may improve + new obesity + diabetes  Related to the article below (Last Update: 5/12/2008)

Nestle Researchers Discover a New Link between Gut Microbiota and ...
FLEXNEWS, France -
?The next questions for Nestl? Research to answer are: Is there a gut microbiota profile that lowers the risk of obesity and diabetes development? ...
With changes in how health care is delivered and financed, the ...
Minneapolis Star Tribune, MN -
Some legislators say more money is needed to cut smoking and obesity significantly. ? Who's in charge: Instead of a new appointed Health Care Transformation ...
Health care bill calls for healthier citizens, plus more coverage ... Minneapolis Star Tribune
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The Money Times
Not All Fat Created Equal: Certain Body Fat Reduces Insulin Resistance
Science Daily (press release) - May 6, 2008
ScienceDaily (May 6, 2008) ? It has long been known that type 2 diabetes is linked to obesity, particularly fat inside the belly. ...
Type of Fat Cells Determines Diabetes Risk ? Subcutaneous Fat Can ... Best Syndication
'Good' and 'bad' fat identified The Press Association
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Zilver? stent for PAD
WHOI, IL -
Other risk factors for PAD include: smoking, diabetes, high blood pressure, elevated cholesterol, obesity, kidney disease and personal or family history of ...
iVital Hosts Seminars: Permanent Weight Loss, Lap-Band, Bariatric ...
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Medical News Today (press release), UK - May 11, 2008
Growth Hormone Doping: New Revelations (8:30 am PDT): Growth hormone doping may no longer go undetected, but does growth hormone improve athletic ...
First with Kids: Baseball safety
BurlingtonFreePress.com, VT -
It is, however, metabolized differently than regular sugar, and it has been found to increase the risk of obesity and diabetes. ...
Correction: Insulin Pumps story
CNNMoney.com - May 9, 2008
However, she said, proper use makes life more bearable and can improve glucose control. Teenagers also have problems keeping their diabetes under control ...
Gut microflora and obesity Nestle expands the possibilities
NutraIngredients.com, France - May 9, 2008
By Stephen Daniells 09-May-2008 - Modifying the population of bacteria in the gut may improve the regulation of glycemic control and reverse the insulin ...
New Ford hospital strives for 5-star treatment
Detroit Free Press, United States - May 9, 2008
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Source: Google News

Obesity and insulin resistance -
BB Kahn, JS Flier - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig
... in this window] [in a new window], Figure 1 ... fat with ?3 adrenergic receptor agonists
may improve whole body ... Alternatively, ?3 agonists may work by changing the ...

Obesity as a cardiovascular risk factor -
JR Sowers - The American Journal of Medicine, 2003 - Elsevier
... to Cite or Link Using DOI (Opens New Window) Copyright ... tumor necrosis factor-a, and
interleukins) that may affect CVD ... Agents that improve insulin sensitivity ...

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin … -
G Boden, GI Shulman - European Journal of Clinical Investigation, 2002 - Blackwell Synergy
... by which the thiazolidinediones may improve hepatic insulin sensitivity [8]. These
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Obesity Evaluation and Treatment: Expert Committee Recommendations -
SE Barlow, WH Dietz - Pediatrics, 1998 - Am Acad Pediatrics
... new family behaviors consistent with the child's new eating and ... Clinicians promote
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… Glycemic Index Physiological Mechanisms Relating to Obesity, Diabetes, and Cardiovascular Disease -
DS Ludwig - JAMA, 2002 - Am Med Assoc
... View larger version (43K): [in this window] [in a new window]. ... A low?glycemic index
diet may in theory improve management of diabetes by lowering early ...

Endothelial Dysfunction in Obesity and Insulin Resistance: A Road to Diabetes and Heart Disease -
AE Caballero - Obesity Research, 2003 - NAASO
... in individuals at risk for type 2 diabetes, may improve clinical cardiovascular ...
(2003) Obesity and risk of ... function in health and disease: new insights into ...

[PDF] Global and societal implications of the diabetes epidemic -
P Zimmet, K Alberti, J Shaw? - Nature, 2001 - direct-ms.org
... Recently, several new obesity- and diabetes-related genes havebeen ... It may therefore
be prudent to treat such ... in any approaches to improve health worldwide ...
-

… of Weight Loss With Orlistat on Glucose Tolerance and Progression to Type 2 Diabetes in Obese Adults -
SB Heymsfield, KR Segal, J Hauptman, CP Lucas, MN … - Archives of Internal Medicine, 2000 - Am Med Assoc
... table: [in this window] [in a new window]. ... with dietary and lifestyle intervention
may improve the insulin ... treatment of obesity, the Swedish Obesity Study, 23 ...

… with nurse follow-up improve self-care and glycemic control among vulnerable patients with diabetes … -
JD Piette, M Weinberger, SJ McPhee, CA Mah, FB … - The American Journal of Medicine, 2000 - Elsevier
... With the advent of new drug therapies for obesity, weight self ... Interventions such
as the one we evaluated may improve public providers? ability to ...

Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. -
KAM Jandeleit-Dahm, C Tikellis, CM Reid, CI … - Journal of Hypertension, 2005 - jhypertension.com
... that interruption of the RAS may improve insulin sensitivity by ... were more effective
at reducing new-onset diabetes ... via local barotrauma, which may explain the ...

Source: Google Scholar

New Role For Protein In Fat Cells May Improve Understanding Of Obesity And Diabetes
Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat. Richard E. Morton and Lahoucine Izem, research scientists at the Cleveland Clinic Foundation, have shown that the protein, called cholesteryl ester transfer protein (CETP), is involved in the cellular storage and regulation of cholesterol and other fats and, as a result, probably has unexpected contributions to obesity and diabetes.
"CETP is known to shuttle different types of fat between lipoproteins - combinations of fat and protein that transport fats in the blood," Morton says. "In this study, we show that CETP also shuttles fats inside fat cells between two separate areas and that fat cells with reduced levels of CETP are unable to process fats normally."

The new study, to be published in the July 27 issue of the Journal of Biological Chemistry, was selected as a "Paper of the Week" by the journal's editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.

Research performed during the past decade has shown that CETP affects how a type of fat called cholesteryl ester is moved from the blood plasma into cells. Since fat cells make abundant CETP, Morton and Izem decided to examine what CETP does inside a fat cell and what would happen to fat cells that are deficient in CETP.

The scientists noticed that fat cells lacking CETP could not make and store cholesterol, cholesteryl ester, and another fat called triglyceride like normal fat cells do. In CETP-deficient cells, cholesteryl ester and triglyceride accumulated in a cellular compartment called the endoplasmic reticulum (ER), while an abnormally low amount of these fats was seen in "lipid droplets" - local accumulations of fat in fat cells.

Morton and Izem suggest that, in normal cells, CETP transfers cholesteryl ester and triglyceride from the ER, where they are made, to the lipid droplets, where they are stored. In cells lacking CETP, only a fraction of both fats is carried from the ER to the lipid droplets. Also, since cholesterol is produced by breaking down cholesteryl ester in lipid droplets, lower levels of cholesteryl ester lead to smaller amounts of cholesterol in the droplets.

"CETP-deficient cells have unbalanced amounts of cholesterol and fats," Morton says. "They have too much cholesteryl ester and triglycerides in the ER and not enough of them in the lipid droplets. Also, these cells sense that they have too much cholesterol, although they actually have low amounts of cholesterol. Overall, the cells don't correctly control the amount of fats they make and store anymore."

A consequence of the abnormal distribution of fats between cell compartments is that cholesteryl ester and triglycerides cannot be used easily. In normal cells, when these two fats accumulate in the droplets, they can be removed from the droplets and then used by the cell after the fats are broken down by enzymes called hydrolases. But since hydrolases are in the droplets and not in the ER, cells low in CETP cannot break down the fats they store as effectively, Morton and Izem say.

The scientists conclude that CETP is probably essential for lipid metabolism and storage in fat cells and that fat tissue is not only an energy storage tissue but also a major endocrine organ.

"CETP deficiency disrupts storage of important fats in fat cells, which can lead to insulin resistance �" a major contributor to diabetes - and the abnormal release of cytokines, proteins that stimulate the immune system," Morton says. "This unexpected contribution of CETP provides a new understanding of how our body stores and regulates fats and of conditions such as obesity and diabetes."
"Possible Role for Intracellular Cholesteryl Ester Transfer Protein in Adipocyte Lipid Metabolism and Storage,"
by Lahoucine Izem and Richard E. Morton

The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 11,900 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society's student members attend undergraduate or graduate institutions.

Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.

For more information about ASBMB, see the Society's Web site at http://www.asbmb.org
 
 
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