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Recent News and Articles on the Keywords: insights into + insight into + leukemia  Related to the article below (Last Update: 5/5/2008)

New insights into the genetic basis of resistance to chemotherapy ...
EurekAlert (press release), DC - Apr 14, 2008
In a new study published in PLoS Medicine, William Evans of St Jude Children?s Research Hospital, Memphis, and colleagues provide new insight into ...
Nature/Medicine Biodiversity loss: It will make you sick!
Accra Daily Mail, Ghana - Apr 27, 2008
The authors point out that the research on gastric brooding frogs could have led to new insights into preventing and treating human peptic ulcers which ...
Source: Google News

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect -
SS Farag, TA Fehniger, L Ruggeri, A Velardi, MA … - Blood, 2002 - caligiurilab.com
Page 1. Review article Natural killer cell receptors: new biology and insights
into the graft-versus-leukemia effect Sherif S. Farag ...

Interpreting patterns of gene expression with self-organizing maps: Methods and application to … -
P Tamayo, D Slonim, J Mesirov, Q Zhu, S Kitareewan … - Proceedings of the National Academy of Sciences of the …, 1999 - pubmedcentral.nih.gov
... of mathematical tools, each providing different types of insight. ... algorithms to organize
genes into a phylogenetic ... inspection of the data to extract insights. ...

IL-6: Insights into Novel Biological Activities -
BE Barton - Clinical Immunology and Immunopathology, 1997 - Elsevier
... pects of IL-6 biology should yield new insight into the ... M binds the high- affinity
leukemia inhibitory factor ... IL-6: INSIGHTS INTO NOVEL BIOLOGICAL ACTIVITIES ...

Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and … -
K Ley - The Journal of Immunology, 1995 - Am Assoc Immnol
... New insights into selectin-mediated attachment and rolling. ... This commentary summarizes
recent insight into the molecular basis of leukocyte rolling gained from ...

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling -
GJPL Kops, BMT Burgering - Journal of Molecular Medicine, 1999 - Springer
... Forkhead transcription factors: new insights into protein kinase B ... contributes to
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New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate … -
MA Sirover - Biochimica et Biophysica Acta (BBA)/Protein Structure and …, 1999 - Elsevier
... New insights into an old protein: the functional ... To gain insight into mechanisms
of endocytosis, CHO ... tubulin polymerization (ie, bundling) into microtubules is ...

… Analysis of the SBDS Protein Family: INSIGHT INTO THE LEUKEMIA-ASSOCIATED SHWACHMAN-DIAMOND … -
C Shammas, TF Menne, C Hilcenko, SR Michell, B … - Journal of Biological Chemistry, 2005 - ASBMB
... determinants underlying the multistep progression to leukemia. ... Insight into the
Pathogenesis of SDS?Affected ... may provide critical insights into the function ...

New Insights into the Biology of the Acute Phase Response -
AF Suffredini, G Fantuzzi, R Badolato, JJ … - Journal of Clinical Immunology, 1999 - Springer
... New Insights into the Biology of the Acute Phase ... New developments into the mecha-
nisms of ... 11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor ...

Recent insights into the mechanism of glucocorticosteroid-induced apoptosis -
CW Distelhorst - Cell Death and Differentiation, 2002 - nature.com
... This review focuses primarily on insights gained in recent ... Wasted phenotype may possibly
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Insights into electromagnetic interaction mechanisms -
R Goodman, M Blank - Journal of Cellular Physiology, 2002 - doi.wiley.com
... exposure to EM fields provides insight into how EM ... epidemiological studies on childhood
leukemia risks, where ... our hope that these insights into EM interaction ...

Source: Google Scholar

Scientists Gain Important Insights Into Deadly Form Of Leukaemia
A new study has provided key insights into the complex molecular events that cause a deadly type of leukaemia and identifies promising new avenues to develop treatments for some of its variant forms.

The research, carried out by scientists at The Institute of Cancer Research illuminates specific mechanisms involved in the development of acute promyelocytic leukaemia (APL).

APL is a cancer of the bone marrow and most cases are caused by the expression of a cancer causing gene called the PML/RARα oncogene. This oncogene is formed by the exchange of genetic material between two chromosomes and gives rise to a protein called fusion protein. In APL, the fusion protein interferes with gene expression and prevents white blood cells behaving normally, leading them to become cancerous.
This study, published recently in Cancer Cell*, has revealed at least three distinctive and essential steps by which the oncogenic RARα fusion complex assembles in APL. As formation of such complexes is crucial for the regulation of genes involved in human cancer, these findings also reveal that these complexes have the potential to be targets for molecular therapy.

Lead researcher, Dr Eric So of The Institute of Cancer Research, said: "These findings not only identify the key elements and potential avenues for therapeutic targeting of this type of leukaemia but also shed light on the detailed mechanisms associated with the mis-regulation of genes in leukaemia."

"Following these results, we will be able to work with colleagues in the Cancer Research UK Centre for Cancer Therapeutics at The Institute to explore the possibility of developing new therapies to target this weakest link in cancers."

The work was funded by the Association for International Cancer Research, Cancer Research UK and Leukaemia Research .

* Cancer Cell, vol 11, issue 7

Read more about Dr So's work in The Institute's Annual Research Report 2006. His article Oncogenic transcription factors in normal and cancer stem cells discusses the roles of various oncogenic transcription factors in both normal and cancer stem cells.

About The Institute of Cancer Research

-- The Institute of Cancer Research is Europe's leading cancer research centre with expert scientists working on cutting edge research. It was founded in 1909 to carry out research into the causes of cancer and to develop new strategies for its prevention, diagnosis, treatment and care. Website at: http://www.icr.ac.uk

-- The Institute works in a unique partnership with The Royal Marsden NHS Foundation Trust, forming the largest comprehensive cancer centre in Europe. This relationship enables close daily contact with those on the frontline in the fight against cancer - the clinicians, the carers and most importantly, the patients.
About the Association for International Cancer Research

-- AICR (Association for International Cancer Research) is a totally independent charity based in St Andrews in Scotland. It has no commercial ties, no links with any particular research institutions and no commitment to follow any particular line of research. It funds what it considers to be the best researchers and the most valuable studies, wherever they are in the world. This innovative approach to funding research has enabled AICR to contribute significantly to furthering man's understanding of cancer.

-- Head office Madras House, St Andrews, Fife KY16 9EH, telephone +44 (0) 1334- 477910. e-mail: aicr@aicr.org.uk

About Cancer Research UK

-- Together with its partners and supporters, Cancer Research UK's vision is to beat cancer.

-- Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer.

-- Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients.

-- Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.

-- Cancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer

-- For further information about Cancer Research UK's work or to find out how to support the charity, please call 020 7009 8820 or visit http://www.cancerresearchuk.org

About Leukaemia Research

-- Over the next five years, Leukaemia Research urgently needs to raise over £100 million to commit to new research across the UK. From basic laboratory research to clinical trials with patients, Leukaemia Research is committed to saving lives by funding high quality, carefully selected research throughout the UK.

-- Leukaemia Research is the only national charity devoted exclusively to improving treatments, finding cures and learning how to prevent leukaemia, Hodgkin's lymphoma and other lymphomas, myeloma and the other related blood disorders, diagnosed in 24,500 people in the UK every year. Further information, including patient information booklets, is available from http://www.lrf.org.uk or call 020 7405 0101.
 
 
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