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Recent News and Articles on the Keywords: eric schoch + eschoch@iupui.edu 317-274-7722 + contact  Related to the article below (Last Update: 5/5/2008)

Saturday: Macks baseball stays perfect at Dome
Chippewa Herald, WI -
The Macks would go on to score four more runs in the inning with consecutive RBI doubles from Jon Schoch and Adam Bohl. After Andrew Walker drove in a run ...
CHIPPEWA FALLS MCDONELL 9, ELK MOUND 2
Leader-Telegram, WI - May 3, 2008
Leading hitters: McDonell - Jon Krejchi 2x5, Hiess 2x3, Jon Schoch 3x4, Andy Walker 3x4. Elk Mound - Day 3x3. WP: Mikey Schaaf (6 IP, 5 H, 4 R, 2 ER, 10 BB, ...
Abigail E. Henderson -- Zumbrota
Post-Bulletin, MN - Apr 15, 2008
Private family services were held April 15 at Christ Lutheran Church in Zumbrota; the Rev. Wayne Schoch officiated. Burial was in Zumbrota Cemetery.
Leader-Telegram staff
Leader-Telegram, WI - Apr 23, 2008
"Schoch has a real live arm," McDonell coach Eric Wedemeyer said. "The ball just explodes out of his hand. He has a real good fastball and he's been working ...
Leader-Telegram staff
Leader-Telegram, WI - Apr 29, 2008
After Jon Schoch's single scored two runs in the top of the seventh, Regis threatened, putting runners on first and third on singles by Roubal and Jimmy ...
McDonell dominates in opener
Chippewa Herald, WI - Apr 16, 2008
McDonell?s Jon Schoch, left, is congratulated by teammate Andy Davis after scoring in the first inning against Eau Claire Immanuel Lutheran Wednesday ...
McDonell baseball preview: Macks expect big things
Chippewa Herald, WI - Apr 8, 2008
Leading the way is pitcher/centerfielder Jon Schoch. The powerful senior is one of the most talented players in Division 3. He batted a staggering .644 last ...
Grand Strand Scoreboard
Myrtle Beach Sun News, SC - Apr 16, 2008
John Schoch 69. Low for month: 1. Wade Cook; 2. Ray Sillup 64; t3. Dave Kelly and Frank Ritrievi 65 4/10-International Golf Club. Master's Partners: 1. ...

Los Angeles Times
Cleanup in Hollywood
Los Angeles Times, CA - Apr 7, 2008
By Deborah Schoch, Los Angeles Times Staff Writer The cops wave over the sleek black Trans Am outside Grauman's Chinese Theatre, and the young man behind ...
Prep Baseballl: Jefferson wins its own tourney
Monroenews.com, MI - Apr 20, 2008
Shayne Shroyer and Bobby Schoch were the winning pitchers for the 5-5 Mules. CANTON - Monroe took a doubleheader from Plymouth Salem 5-3 and 13-5. ...
Source: Google News

The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A … -
JK Yano, MR Wester, GA Schoch, KJ Griffin, CD … - Journal of Biological Chemistry, 2004 - ASBMB
The structure of P450 3A4 was determined by x-ray crystallography to 2.05-?
resolution. P450 3A4 catalyzes the metabolic clearance of a large number of
clinically used drugs, and a number of adverse drug-drug interactions ...

Structure of Human Microsomal Cytochrome P450 2C8: EVIDENCE FOR A PERIPHERAL FATTY ACID BINDING SITE -
GA Schoch, JK Yano, MR Wester, KJ Griffin, CD … - Journal of Biological Chemistry, 2004 - ASBMB
A 2.7-? molecular structure of human microsomal cytochrome P450 2C8 (CYP2C8)
was determined by x-ray crystallography. The membrane protein was modified for
crystallization by replacement of the hydrophobic N-terminal transmembrane ...

The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-A Resolution -
MR Wester, JK Yano, GA Schoch, C Yang, KJ Griffin, … - Journal of Biological Chemistry, 2004 - ASBMB
The structure of human P450 2C9 complexed with flurbiprofen was determined to
2.0 ? by x-ray crystallography. In contrast to other structurally characterized
P450 2C enzymes, 2C5, 2C8, and a 2C9 chimera, the native catalytic domain ...

The Presynaptic Active Zone Protein RIM1a Is Critical for Normal Learning and Memory -
CM Powell, S Schoch, L Monteggia, M Barrot, MF … - Neuron, 2004 - Elsevier
The active zone protein RIM1a is required both for maintaining normal
probability of neurotransmitter release and for long-term presynaptic
potentiation at brain synapses. We now demonstrate that RIM1a -/- mice ...

Gastroduodenal and colonic stents: Review article
CL ZOLLIKOFER, R JOST, E SCHOCH, M DECURTINS - Seminars in interventional radiology, 2001 - cat.inist.fr
Gastroduodenal and colonic stents: Review article. Christoph L ZOLLIKOFER,
Res JOST, Eric SCHOCH, Marco DECURTINS Seminars in interventional radiology
18:33, 265-280, Thieme, 2001. Appareil digestif ...

Recanalization of Acute and Subacute Femoropopliteal Artery Occlusions with the Rotarex Catheter: … -
SR Duc, E Schoch, M Pfyffer, R Jenelten, CL … - CardioVascular and Interventional Radiology, 2005 - Springer
Purpose: To assess the efficacy and safety of a new rota- tional catheter for
percutaneous removal of fresh and or- ganized thrombi in the femoropopliteal
artery. Methods: Forty-one limbs in 38 patients (age 56?90 years, mean ...

Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent … -
YY Huang, SS Zakharenko, S Schoch, PS Kaeser, R … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
The synaptic vesicle protein Rab3A is a small GTP-binding protein that interacts
with rabphilin and RIM1 , two presynaptic substrates of protein kinase A (PKA).
Mice lacking RIM1 and Rab3A have a defect in PKA-dependent and NMDA ...

Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of … -
… , JK Yano, RL Reynald, GA Schoch, KJ Griffin, CD … - Journal of Biological Chemistry, 2007 - ASBMB
Microsomal cytochrome P450 family 1 enzymes play prominent roles in xenobiotic
detoxication and procarcinogen activation. P450 1A2 is the principal cytochrome
P450 family 1 enzyme expressed in human liver and participates extensively ...

Colorectal Stenting: An Effective and Costsaving Therapy in Acute Leftsided Obstruction
… Jost, R Jost, M Decurtins, E Schoch, B Brunner, C … - Gastrointestinal Endoscopy, 2004 - Elsevier
Background / Purpose: In a previous study (1) we demonstrated that metallic
stent placement in acute colonic obstruction is a minimally invasive and cost
effective procedure allowing single step surgery in most cases. The purpose ...

Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site … -
… Melet, C Marques-Soares, GA Schoch, AC Macherey, M … - Biochemistry, 2004 - pubs.acs.org
The structural determinants of substrate specificity of human liver cytochrome
P450 2C8 (CYP2C8) were investigated using site-directed mutants chosen on the
basis of a preliminary substrate pharmacophore and a three-dimensional (3D) ...

Source: Google Scholar

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University

Advanced therapy offers cure for relapsed cancer patient

INDIANAPOLIS -- Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant, according to an Indiana University School of Medicine report in the July 26 issue of the New England Journal of Medicine.

About 90 percent of testicular cancer patients respond to traditional therapy, which involves multiple courses of cisplatin, first used successfully in the treatment of this disease by Lawrence Einhorn, M.D., at Indiana University Cancer Center in the early 1980s. That course of therapy turned a disease from a mostly fatal cancer into one of the more curable forms of cancer for men, who typically are in their 20s when diagnosed with testicular cancer.

It is rare for the NEJM to carry a retrospective study from a single institution that is not a randomized study. This review looks at the outcome of 184 patients with metastatic testicular cancer. Dr. Einhorn and colleagues demonstrated that the disease is potentially curable with a high dose chemotherapy and stem cell transplant using cells harvested from the patient before the initial chemotherapy infusion.

The patients received carboplatin chemotherapy at five times the dosage administered to men receiving initial therapy. A side effect of the high dosage is a reduction of blood cells so a stem cell transplant is given to replenish the body’s immune system through a process similar to a blood transfusion. Three to four weeks later the entire process is repeated.

“The message for patients is that through research, diligence and new technologies there is hope,” said Dr. Einhorn, professor of medicine at the Indiana University Melvin and Bren Simon Cancer Center and the lead author of the study. “The bar is steadily being raised and more patients are being saved.”

“This review confirms that high-dose chemotherapy combined with a stem cell transplant can provide a cure for a group of patients with relapsed testicular cancer,” said Rafat Abonour, M.D., associate professor of medicine in the division of hematology/oncology and associate dean for clinical research at the IU School of Medicine.

Although the number of relapsed testicular cancer patients is small, the IU Simon Cancer Center treats a majority of them. As a leader in this treatment, the researchers were able to collect the necessary data for the NEJM retrospective.

For the patients each year who are treated with this therapy, there is renewed hope. “This is new medicine and it tells patients that cures are on the horizon,” said Stephen D. Williams, M.D., director of the IU Simon Cancer Center and a co-author of the paper.
Other IU co-authors include Amy Chamness, B.A.; Mary J. Brames, R.N.; and Susan M. Perkins, Ph.D.
 
 
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