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Recent News and Articles on the Keywords: brooke grindlinger + grindlinger press_releases@the-jci.org + contact  Related to the article below (Last Update: 5/5/2008)

The X in sex: how the X chromosome controls our lives
BU Grindlinger - Journal of Clinical Investigation, 2003 - pubmedcentral.nih.gov
Copyright ? 2003, American Society for Clinical Investigation. The X in sex: how
the X chromosome controls our lives. Reviewed by Brooke Urquhart Grindlinger. ...

Twinkie, deconstructed: My journey to discover how the ingredients found in processed foods are …
B Grindlinger - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov
... what America eats. Reviewed by Brooke Grindlinger. Journal of Clinical
Investigation, New York, New York, USA. E-mail: science_editor ...
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[CITATION] Elizabeth, Jane, Mattie, and Pecola: the changing heroine in Anglo-American fiction by women
MB Grindlinger - 1999 - James Madison University

Can I quote you on that? -
B Grindlinger - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig
... of birth control. And yes, you can quote me on that. Brooke Grindlinger
Science Editor 1. Wang, H., et al. 2006. Fatty acid amide ...

Evolution, not revolution -
LA Turka - Journal of Clinical Investigation, 2007 - pubmedcentral.nih.gov
... Acknowledging their critical contributions in the JCI, we have asked Ushma Neill
and Science Editor Brooke Grindlinger to continue in their roles, and we are ...

Hello, goodbye
AR Marks - Journal of Clinical Investigation, 2007 - pubmedcentral.nih.gov
... Our full-time professional editors, Ushma Savla Neill, Brooke Grindlinger, and Karen
Honey have added stability and a consistent level of quality that is ...

[PDF] Small Journals Can Get Press Coverage Too
B Black - Science, 2004 - councilscienceeditors.org
... ?We try to make our releases understandable to a nonspecialist audience?, comments
Brooke Grindlinger, the science editor of the Journal of Clinical ...

Predictors of backrest elevation in critical care -
MJ Grap, CL Munro, S Bryant, B Ashtiani - Intensive & Critical Care Nursing, 2003 - Elsevier
... Mary Jo Grap, Cindy L. Munro, Sandra Bryant and Brooke Ashtiani Accepted 28 February
2003. ; Available online 15 April 2003. Abstract. ... 1988; Grindlinger et al. ...

Reflecting on 80 years of excellence -
U Savla - Journal of Clinical Investigation, 2004 - pubmedcentral.nih.gov
... relationships between drug manufacturers and authors of studies submitted
and/or published in the JCI. Brooke Grindlinger, Science Editor. ...

Microbiology of Nosocomial Sinusitis in Mechanically Ventilated Children -
I Brook - Archives of Otolaryngology- Head and Neck Surgery, 1998 - Am Med Assoc
... 1993;21:1132-1138. ISI | PUBMED. 11. Humphrey MA, Simpson GT, Grindlinger GA. ... 15.
Brook I. Bacteriological features of chronic sinusitis in children. JAMA. ...

Source: Google Scholar

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation

A friendly foe -- Bacteria residing in the gut boost immune response to tumors

One potent, immune-based treatment for cancer is total body irradiation (TBI). This approach first depletes the body of the population of immune cells known as lymphocytes and then involves the adoptive transfer of tumor-specific T cells to the patient. Lymphodepletion has previously been shown to improve the ability of tumor-specific T cells to cause tumor regression. In a study appearing online on July 26 in advance of publication in the August print issue of the Journal of Clinical Investigation, Nicholas Restifo and colleagues from the National Cancer Institute show that, in mice, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that a disruption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach for cancer.

A specific population of bacteria present in our gut is crucial to our health. However, some treatments for cancer, particularly those that deplete the body’s immune cells, have high potential to disrupt the natural balance between our bodies and these commensal microorganisms, causing disease. Restifo and colleagues subjected mice genetically deficient in lymphocytes to TBI and found that, like TBI-treated mice with intact lymphocytes, TBI was still able to positively augment the function of adoptively transferred tumor-specific CD8+ T cells and cause tumor regression. This surprising result indicated that another mechanism for the efficacy of TBI also exists. They found that in these mutant, irradiated mice the lining of their gut was injured, allowing the passage of commensal bacteria from the gut to the lymph nodes, where the immune response to their presence increased the activation of tumor-specific CD8+ T cells and resulted in tumor regression. This effect was found to involve toll-like receptor 4. Conversely, a reduction in the number of host microorganisms by the use of antibiotics reduced the beneficial effects of TBI on tumor regression in these animals. In summary, the results of the study demonstrate that the disruption of the host/microorganism balance by TBI and the resulting transient bacterial infection is a key mechanism driving the increased reactivity of tumor-specific CD8+ T cells and subsequent tumor regression in mice.

###

TITLE: Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

AUTHOR CONTACT:

Nicholas P. Restifo or Chrystal M. Paulos

National Cancer Institute, Bethesda, Maryland, USA.

Phone : (301) 496-4904; Fax : (310) 496-0011; E-mail: restifo@nih.gov or paulosc@mail.nih.gov

View the PDF of this article at: https://www.the-jci.org/article.php?id=32205


 
 
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