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Recent News and Articles on the Keywords: joseph bonner + 212-327-8998 bonnerj@rockefeller.edu + contact  Related to the article below (Last Update: 7/8/2008)

KSU honors Bonner students
Bonner Springs Chieftain,  USA - Jul 2, 2008
The following Bonner Springs students at Kansas State University received semester honors: Leslie Marie Holtzen, Kyle Cameron Parker, ...
Thanks to a blessing at St. Joseph School
Progress Index, VA - Jun 25, 2008
Ruth Bonner recently said "goodbye" to the students and staff as principal of St. Joseph School. We hope she will be saying "hello" again this fall in some ...
School News
North County Journal, MO -
They are NATHAN KIRCHOFF, Bridgeway Elementary, first place in the 4-5th grade division; and GIANNA BONNER, Willow Brook Elementary, second place in the ...
Sanctuary for teens
Today's Sunbeam - NJ.com, NJ - Jul 5, 2008
Not to say that you have to have a problem to come to the teen center," said Will Bonner, SODAT's prevention services manager. "There is going to be some ...
AT&T sees iPhone subsidy hurting earnings
guardian.co.uk, UK - Jun 9, 2008
"The initial hit is not good but they don't have that ongoing license fee," said Joseph Bonner, an analyst at Argus Research. "Long term it might actually ...T - AAPL
Team preview: Florida Atlantic - College Football
ESPN - Jul 3, 2008
Junior Chris Bonner (6-3, 195) returns as the other incumbent starter at receiver. Bonner finished last season with 25 receptions for 420 yards and three ...
Honor Roll Plumstead Christian
phillyBurbs.com, PA - Jul 4, 2008
Sara Alsop, Zachary Bonner, Daniel Caponetti, Benjamin DeCarlo, Nicholas Diana, Joanna Fretz, Danielle Griffith, Dana Hayes, Yi Liu, Troy C. Maychuk, ...
By: Bill Bonner & The Daily Reckoning Crew
Gold Seek - Jun 20, 2008
According to market expert Joseph Granville: ?In a bull market, when the 200DMA is rising, each time ?price? visits the 200DMA, it represents a buying ...
Kerins became the ace Bonner needed
Delaware County Daily Times, PA - Jun 21, 2008
?He was a shy kid when I first met him,? said Bonner coach Joe DeBarberie. ?I remember Charlie Longen, our pitching coach, looking at him as a freshman and ...
Spring 2008 Accolades at Draughons Junior College
Clarksville Leaf Chronicle, TN - Jul 7, 2008
... Phillip Allen, Destrie Baier, Angela Bailiff, Willie Baldwin, Hector Barrios, Mercedes Barrios, Larry Bonner, Brandi Brown, Jennie Brown, Robyn Bryant, ...
Source: Google News

Statins and the Risk of Colorectal Cancer -
… , PDR Higgins, R Almog, JD Bonner, HS Rennert, M … - New England Journal of Medicine, 2005 - content.nejm.org
Results In analyses including 1953 patients with colorectal cancer and 2015
controls, the use of statins for at least five years (vs. the nonuse of statins)
was associated with a significantly reduced relative risk of colorectal ...

BLM Heterozygosity and the Risk of Colorectal Cancer -
… , R Almog, P Kolachana, JD Bonner, T Kirchhoff, LP … - Science, 2002 - sciencemag.org
Genomic instability is a hallmark of cancer and is featured prominently in Bloom
syndrome. Bloom syndrome, the prototype of somatic mu- tational disorders, is a
rare autosomal recessive disorder characterized by a profound predispo- ...

[CITATION] Upper management control of new product development projects and project performance -
JM Bonner, RW Ruekert, OC Walker - AN INTERNATIONAL PUBLICATION OF THE PRODUCT DEVELOPMENT & …, 2002 - Blackwell Synergy
While some degree of freedom and flexibility is an essential ingredient to
productive cross-functional NPD teams, upper-managers are faced with the
challenge of instituting effective control mechanisms which head projects ...

Phenotype of Microsatellite Unstable Colorectal Carcinomas: Well-Differentiated and Focally Mucinous … -
JK Greenson, JD Bonner, O Ben-Yzhak, HI Cohen, I … - The American Journal of Surgical Pathology, 2003 - ajsp.com
The phenotypic markers of colorectal carcinomas with microsatellite instability
have been widely studied and include mucinous or poor differentiation, prominent
host response, a circumscribed growth pattern, histologic heterogeneity, ...

Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouse
JJ Bonner, HC Slavkin - Immunogenetics, 1975 - Springer
Abstraet. Data have been obtained indicating that cortisone-induced cleft palate
in the mouse is linked to the H-2 a complex. Cortisone (2.5 mg) was administered
to pregnant females on days 11 through 14 of pregnancy. On day 17 of ...

Political Risks in International Construction -
DB Ashley, JJ Bonner - Journal of Construction Engineering and Management, 1987 - pubs.asce.org
Political risk identification, measurement, and management are key to successful
international construction contracting. Multinational contractors are
particularly sensitive to quick, unexpected change in the political ...

BRCA1 and BRCA2 Founder Mutations and the Risk of Colorectal Cancer -
BL Niell, G Rennert, JD Bonner, R Almog, LP Tomsho … - jnci, 2004 - jnci.oxfordjournals.org
Background: Mutations in BRCA1 and/or BRCA2 (BRCA1/2) profoundly increase the
risks of breast and ovarian cancers, but it is unclear whether mutations in
these genes increase the risk of colorectal cancer. We investigated BRCA1/2 ...

EGF Gene Polymorphism and the Risk of Incident Primary Melanoma -
… , JT Elder, LP Tomsho, JD Bonner, TM Johnson, J … - Cancer Research, 2004 - AACR
Overexpression of the epidermal growth factor (EGF) pathway has been implicated
in melanoma pathogenesis, and a recent case-control study identified a single
nucleotide polymorphism (G to A) in the EGF gene where the G allele was ...

History and Molecular Genetics of Lynch Syndrome in Family GA Century Later -
… , SB Gruber, KA Meister, J Bonner, P Watson, AJ … - JAMA, 2005 - Am Med Assoc
Context In 1895, Aldred Scott Warthin, MD, PhD, initiated one of the most
thoroughly documented and longest cancer family histories ever recorded. The
unusually high incidence and segregation of cancers of the colon, rectum, ...

[CITATION] Selecting Influential Business-to-Business Customers in New Product Development: Relational …
JM Bonner, OC Walker - Journal of Product Innovation Management, 2004 - Blackwell Synergy
This study examines how the most influential business-to-business (B2B)
customers, both existing and potential, involved in providing input to a new
product development (NPD) project influence new product advantage. As the ...

Source: Google Scholar

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University

MicroRNA works with Ago2 protein to regulate blood cell development

MicroRNAs became the stars of the RNA universe when, in 2001, scientists found that these short RNAs can control whether or not genes are expressed. This month, scientists at Rockefeller University and the Wellcome Trust cast new light on the genesis of these key biological regulators and how they carry out their function. These provocative new findings were reported online July 12 in the journal Genes & Development.

While microRNAs are made in large amounts in every cell from plants to humans, Dónal O’Carroll, a research associate in Alexander Tarakhovsky’s lab at The Rockefeller University, has focused on understanding how they regulate the development of one particular system: the hematopoietic system.

“This is a system where similar kinds of stem cells give rise to all the different types of blood cells in the body, so you can definitively address whether microRNAs are involved in the processes by which they specialize and develop,” says O’Carroll.

Instead of making proteins, these snippets of RNA repress their synthesis. They bind to messenger RNAs (mRNAs) — the blueprints for proteins — and either target them for destruction or inhibit their protein-making output. In order for microRNA to find its target mRNA, it needs the help of the protein Ago2, the only member of the Argonaute family of proteins that has a “slicer” function: That is, once microRNA binds with its target, it cleaves it, effectively stopping mRNA’s ability to make proteins.

Since the “slicer” activity of Ago2 would be the most efficient way of regulating microRNA function, O’Carroll wanted to see whether it plays a role in the development of blood cells.

In the bone marrow of adult mice — where their blood stem cells reside — O’Carroll conditionally knocked out the gene that encodes Ago2. Two months later, O’Carroll observed that they had developed anemia and enlarged spleens, and noted that although the stem cells still gave rise to all blood cell types, the development of two of them was severely affected: B lymphocytes, which contribute to the production of antibodies, and red blood cells.

When he looked at the Ago2-deficient mice’s blood cells, he also saw that the microRNA levels, though not zero, were much reduced, indicating that Ago2 is essential for microRNA homeostasis during the early development of blood cells.

To specifically test the importance of Ago2’s “slicer” activity, O’Carroll then genetically reconstituted the Ago2-deficient stem cells with either wild type Ago2 or a modified version of it that rendered the “slicer” activity inactive. A few weeks later, both conditions — the anemia and the enlarged spleen — in both groups of mice were cured, suggesting that this feature of Ago2 makes only a minor contribution to its biological function. The finding was surprising since the “slicer” function is unique to Ago2.

“At least within this system, ‘slicer’ activity doesn’t have a role in the execution of microRNA function, but Ago2 does have a special role in the maintenance of microRNA levels,” says O’Carroll, who recently accepted a position at the European Molecular Biology Laboratory in Rome.

Within the blood system, low levels of microRNA are not life-threatening during development but do have a distinct effect on different blood cell lineages.

“The results have caused us to think about the differential sensitivity of distinct developmental processes to microRNA levels,” says Tarakhovsky. “It remains to be seen to what extent specialized functions of developing cells in the blood system depend on microRNA.”

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