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Recent News and Articles on the Keywords: karen richardson + krchrdsn@wfubmc.edu 336-716-4453 + contact  Related to the article below (Last Update: 5/12/2008)

Harry's seen it all in 100 years
Peterborough Today, UK -
Mr Richardson's daughter-in-law, Karen, said: "Harry always said he would live to see 100 just so he would get the customary congratulations from the Queen. ...
Record entries for princess search
Stourbridge News,  UK -
Judging takes place at the Richardson Hall, Lawnswood Road, Wordsley, from 4pm. The winner of the top title will open the Wordsley Festival fun-day at ...
Sunday, May 11, 2008: Mt. St. Mike's McGovern clears 15-7 in pole ...
NY State Sportswriters Association, NY - May 11, 2008
One-girl show: In Texas over the weekend, junior Bonnie Richardson won the 1A team track and field championship for Rochelle High School all by herself by ...
This pair?s full of care
Marshall Independent, MN - May 9, 2008
By Cindy Votruba Wherever there is a Whopper Hopper, Karen Beebout of Marshall will usually jump right in with her daycare children. ...
Plano community calendar
Dallas Morning News, TX - May 11, 2008
'A COMPANY OF WAYWARD SAINTS' will be performed by the Richardson High School Eagle Repertory Theatre at 7:30 pm Monday and Tuesday in the Black Box Theatre ...
Hello, Cupcake book
ABC7Chicago.com,  USA - May 6, 2008
By Karen Tack & Alan Richardson What's cuter than a cupcake? How about a penguin, a puppy, or a space alien? Put them together and you've got HELLO, ...
Shepherd's Bushy Park victory
Epsom Guardian, UK -
... 62.57% JM14 Tasis England School 136 Ian Richardson M 22:41 60.62% VM40-44 Kingston AC & Polytechnic Harriers 137 William Smith M 22:43 64.42% VM45-49 ...
High Schools plan reunions
Ada Evening News, OK -
... Jackie Berger, Gary Cartwright, Tommy Love, Paula Miller, Paul Morgan, Don Murray, Don Paulson, Karen Scott, Jean Shook and Huerlyne Richardson. ...
Xavier University honors graduates today
The Times-Picayune - NOLA.com, LA - May 10, 2008
Master of arts in teaching: Kevin Chinedu Akor, Constance Osberry Alphonse, Karen Monica Brown, Karen Rita Darby-Monlyn, Lillian Joseph Henry, ...
Isakson wants to stay in Senate
Atlanta Journal Constitution,  USA - May 9, 2008
House Speaker Glenn Richardson's name also has been mentioned, but many political experts doubt he'll run. Richardson was out of town Thursday and could not ...
Source: Google News

Novel methods improve prediction of species' distributions from occurrence data -
… , S J. Phillips, K Richardson, R Scachetti-Pereira … - Ecography, 2006 - Blackwell Synergy
... M. Overton, A. Townsend Peterson, Steven J. Phillips, Karen Richardson, Ricardo
Scachetti-Pereira, Robert E. Schapire, Jorge Sober?n, Stephen Williams, Mary S.
Wisz, Niklaus E. Zimmermann (2006) Novel methods improve prediction of species ...

Biogeographical concordance and efficiency of taxon indicators for establishing conservation … -
C Moritz, KS Richardson, S Ferrier, GB Monteith, J … - Proceedings: Biological Sciences, 2001 - JSTOR
Biogeographical Concordance and Efficiency of Taxon Indicators for Establishing
Conservation Priority in a Tropical Rainforest Biota. Craig Moritz. Karen S. Richardson.
Simon Ferrier. Geoffrey B. Monteith. John Stanisic. Stephen E. Williams ...

Mapping More of Terrestrial Biodiversity for Global Conservation Assessment -
S FERRIER, GVN POWELL, KS RICHARDSON, G MANION, JM … - BioScience, 2004 - bioone.org
Global conservation assessments require information on the distribution of
biodiversity across the planet. Yet this information is often mapped at a very
coarse spatial resolution relative to the scale of most land-use and ...

[PDF] The complete genome sequence of the gastric pathogen -
… , S Peterson, B Loftus, D Richardson, R Dodson, HG … - NATURE, 1997 - microimm.queensu.ca
17. F?l?p, V., Moir, JWB, Ferguson, SJ & Hajdu, J. Crystallisation and
preliminary crystallographic study of cytochrome cd 1 nitrite reductase from
Thiosphaera pantotropha. J. Mol. Biol. 232, 1211?1212 (1993). 18. Berger, ...

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus … -
… , JD Peterson, DL Richardson, AR Kerlavage, DE … - Nature, 1997 - nature.com
Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its
genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436
open reading frames (ORFs). The information processing systems and the ...

Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi -
… Tomb, RD Fleischmann, D Richardson, J Peterson, AR … - Nature, 1997 - nature.com
The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of
Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17
linear and circular plasmids with a combined size of more than 533,000 base ...

Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga … -
… Pratt, CA Phillips, D Richardson, J Heidelberg, GG … - Nature, 1999 - nature.com
The 1,860,725-base-pair genome of Thermotoga maritima MSB8 contains 1,877
predicted coding regions, 1,014 (54%) of which have functional assignments and
863 (46%) of which are of unknown function. Genome analysis reveals ...

DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae -
… TD Read, H Tettelin, D Richardson, MD Ermolaeva, J … - Nature, 2000 - nature.com
Here we determine the complete genomic sequence of the Gram negative,
-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp).
The genome consists of two circular chromosomes of 2,961,146 bp and ...

Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete -
… , J Peterson, H Khalak, D Richardson, JK Howell, M … - Science, 1998 - sciencemag.org
The complete genome sequence of Treponema pallidum was determined and shown to
be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading
frames). Systems for DNA replication, transcription, translation, and ...

Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1 -
… , ML Gwinn, WC Nelson, DL Richardson, KS Moffat, H … - Science, 1999 - sciencemag.org
The complete genome sequence of the radiation-resistant bacterium Deinococcus
radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base
pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 ...

Source: Google Scholar

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center

Diabetes drugs increase risk of heart failure, research shows

WINSTON-SALEM, N.C. – A class of drugs commonly used to treat type 2 diabetes may double the risk of heart failure, according to a new analysis by researchers at Wake Forest University School of Medicine and colleagues.

Based on a review of research studies and case reports involving more than 78,000 patients, the authors concluded that the risk of heart failure may be up to 100 percent higher (depending on the type of study) in patients taking thiazolinediones (which includes Avandia® and Actos®). These drugs are known to enhance insulin sensitivity. The authors estimated that one additional patient with type 2 diabetes would develop heart failure for every 50 patients taking the drugs over a 26-month period.

The results were published online in May 2007 by Diabetes Care and will appear in the August print issue.

“These drugs are currently used by more than 3 million diabetic patients in the U.S. alone, suggesting that several thousand could be harmed,” said Sonal Singh, M.D., lead author and an assistant professor in internal medicine at Wake Forest.

Earlier this year, one of the drugs in this class (Avandia®) was linked to an increased risk of heart attack and death from cardiovascular causes.

The current analysis looked at a potential link between the drugs and heart failure, which is the inability of the heart to meet the body’s demands. Heart failure is a very common condition in the elderly and one of the costliest to society. Common symptoms include shortness of breath and the inability to exercise including, in some cases, even to walk short distances.

The authors hypothesize that fluid retention caused by the drugs may trigger heart failure in susceptible people.

Heart failure occurred equally at high and low doses. In fact, heart failure even occurred in some patients who were taking doses below those commonly prescribed. The medium time for the onset of heart failure was 24 weeks after beginning drug therapy.

The adverse reaction was not limited to the elderly – one-quarter of cases occurred in people younger than 60. Heart failure occurred equally among men and women.

The product label for both drugs warns against their use in patients with more severe cases of heart failure. The label also cautions about the increased risk of heart failure if used in combination with insulin. However, the current analysis found that the risk wasn’t confined just to patients on insulin, and it occurred even among patients without any risk factors for heart failure. “Our findings support current efforts by the FDA to add a black box warning to the labeling for those agents,” said co-investigator Curt Furberg, M.D., Ph.D., from Wake Forest.

“The occurrence of heart failure several months after initiation of treatment suggests a long-term effect of the drugs, which may not be avoided by beginning with low doses,” said Singh.

The authors called for additional research to evaluate whether there are differences between drugs in the class and how to best manage patients who experience heart failure while on the drugs.

###

In addition to Furberg, Yoon K. Loke, M.B.B.S., M.D., with the University of East Anglia in the United Kingdom, was also a co-researcher.

Media Contacts: Karen Richardson, krchrdsn@wfubmc.edu, or Shannon Koontz, shkoontz@wfubmc.edu, 336-716-4587.

Wake Forest University Baptist Medical Center is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University Health Sciences, which operates the university’s School of Medicine. U.S. News & World Report ranks Wake Forest University School of Medicine 18th in primary care and 44th in research among the nation's medical schools. It ranks 35th in research funding by the National Institutes of Health. Almost 150 members of the medical school faculty are listed in Best Doctors in America.
 
 
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