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Recent News and Articles on the Keywords: against asthma + improve asthma + asthma  Related to the article below (Last Update: 5/5/2008)


Times Online
Is our zeal for cleanliness making us ill?
Times Online, UK -
The incidence of certain illnesses - asthma, eczema and respiratory allergy and autoimmune diseases such as arthritis and multiple sclerosis - has soared. ...
Starting Flu Vaccination in August Could Help Protect Nearly 11 ...
Earthtimes (press release), UK -
FluMist should not be administered to any individual with asthma and to children less than five years of age with recurrent wheezing unless the potential ...
Dust Mites Trump Asthma Prevention Guidelines
Washington Post, United States - Apr 16, 2008
WEDNESDAY, April 16 (HealthDay News) -- Trying to alleviate your asthma by eliminating household dust? Forget about it, a new study suggests. ...
Figure Skater Peggy Fleming Teams With HealthSaver: Allergies and ...
Earthtimes, UK - Apr 15, 2008
Most moderate to severe asthma sufferers also battle allergic rhinitis. Controlling that complication may improve the asthma associated with it. ...
Special Report: Health and death behind bars
East Valley Tribune, AZ - May 3, 2008
Inmates in county jails have died from asthma attacks, pneumonia, infections, diabetes, heart disease and other commonly treated ailments, according to ...
Dispensing with routine
Guardian, UK - Apr 8, 2008
City and Hackney PCT has a contract with community pharmacy services to improve the management of asthma. The asthma medicines support service identifies ...

ReadMedia (Press Release)
Lung Association Hails Introduction of Legislation to Improve ...
ReadMedia (Press Release), NY - Apr 16, 2008
?This legislation will protect all New Yorkers, especially those suffering from asthma and lung disease, who are currently left without recourse when it ...
Childhood Vaccination
Canada.com, Canada - May 2, 2008
Safety and long-term effects: There have been concerns that vaccines may increase the risk of SIDS (sudden infant death syndrome), asthma, and autism. ...
Austin center charts different course on autism
Austin American-Statesman, TX - May 3, 2008
She credits the center with improvements in her other sons ? two of whom struggle with attention deficit disorders, she says, and another with asthma. ...
Briefs: Keeping home clean reduces allergens
Tampabay.com, FL - Apr 28, 2008
By Times Staff, Wires Allergic asthma can cause permanent damage to the airways. The American Academy of Allergy, Asthma & Immunology suggests you decrease ...
Source: Google News

Surveillance for asthma?United States, 1980?1999 -
DM Mannino, DM Homa, LJ Akinbami, JE Moorman, C … - MMWR Surveill Summ, 2002 - cdc.gov
... provide scientifically validated programs to improve provider and ... nhlbi.nih.gov/
guidelines/asthma/asthgdln.htm ... Action against asthma: a strategic plan for the ...

… Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma 1 -
JN Kline, TJ Waldschmidt, TR Businga, JE Lemish, … - The Journal of Immunology, 1998 - Am Assoc Immnol
... of CpG ODN as an adjuvant may dramatically improve the utility of immunotherapy
in asthma. ... the use of ODN to protect against eosinophilic inflammation ...

Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey -
J Riedler, C Braun-Fahrl?nder, W Eder, M Schreuer … - The Lancet, 2001 - Elsevier
... this survey have been validated against bronchial hyperresponsiveness ... both asthma
diagnosis and asthma symptoms ... findings could help to improve understanding of ...

Improving Childhood Asthma Outcomes in the United States: A Blueprint for Policy Action -
M Lara, S Rosenbaum, G Rachelefsky, W Nicholas, SC … - Pediatrics, 2002 - Am Acad Pediatrics
... communities asthma-friendly is needed to improve the health ... with asthma and provide
them with asthma-safe home ... basic goal of insuring children against the cost ...

Changes in asthma prevalence: two surveys 15 years apart -
ML Burr, BK Butland, S King, E Vaughan-Williams - Archives of Disease in Childhood, 1989 - fetalneonatal.com
... Home page ST Holgate and G Lack Improving the management of ... and BP Mahon Acellular
Pertussis Vaccine Protects against Exacerbation of Allergic Asthma Due to ...

… compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one … -
L Bjermer, H Bisgaard, J Bousquet, LM Fabbri, AP … - BMJ: British Medical Journal, 2003 - pubmedcentral.nih.gov
... as add-on treatment to fluticasone were beneficial in improving the quality ... relaxation
by itself could serve as a protective factor against asthma exacerbations ...

Improving Care for Minority Children With Asthma: Professional Education in Public Health Clinics -
D Evans, R Mellins, K Lobach, C Ramos-Bonoan, M … - Pediatrics, 1997 - Am Acad Pediatrics
... Bureau of Child Health that made this program to improve asthma care possible. ... Med
J 1983; 286:1253-1256 [Medline]; Colver AF Community campaign against asthma. ...

Inadequate Therapy for Asthma Among Children in the United States -
JS Halterman, CA Aligne, P Auinger, JT McBride, PG … - Pediatrics, 2000 - Am Acad Pediatrics
... 5 ,6 Such medications protect against asthma exacerbations leading to ... Greenberger
P Preventing hospitalizations for asthma by improving ambulatory management ...

Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: … -
J Bousquet, S Gaugris, VS Kocevar, Q Zhang, DD Yin … - Clinical & Experimental Allergy, 2005 - Blackwell Synergy
... of nasal conditions confers significant protection against exacerbations of ... leading
to an emergency visit for asthma. ... of rhinitis may improve coexisting asthma ...

Environmental factors influencing the development and progression of pediatric asthma -
E von Mutius - The Journal of Allergy and Clinical Immunology, 2002 - Elsevier
... environmental exposure to endotoxin may offer protection against allergy and ... ways
to prevent the development of asthma and atopy and improve long-term ...

Source: Google Scholar

Research May Lead To Improved Therapeutics Against Asthma
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein -- LTC4 synthase -- which has a major influence on the development of asthma. LTC4 synthase is extremely difficult to analyze, and previously only low resolution information has been available on two membrane protein structures from human. The scientists now believe that their work will enable the development of new and better therapeutics against inflammations in the pulmonary tract.

Asthma attacks are caused by an acute inflammatory reaction in the airways, a reaction that is largely due to actions of LTC4 synthase. For this reason asthma medicines often aim at blocking the downstream effects of LTC4 synthase. However, there is a need for new pharmaceutical alternatives, since not all patients respond to the existing medicines.

Scientists at the Department of Medical Biochemistry and Biophysics have now, with the help of the two EU networks 'EICOSANOX' and 'E-Mep', elucidated the three dimensional structure of the LTC4 synthase at 2.0 -- resolution (1 - = 1 Angstrom = 10-10 m = 0,000 000 000 1 m). It is clear from the structure that the protein has three identical subunits, each of them consisting of four spiral structures that span the nuclear membrane.

Also the exact position and characteristics of the active sites, where activating or blocking molecules can bind, have been identified. With this knowledge it is now possible to tailor new molecules that can block the LTC4 synthase.

The new results are also very important as they can lead the way for the development of new and more effective therapeutics against other diseases. Some 40 % of the proteins of interest for pharmaceutical developments are membrane proteins.

Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function.

The present study is likely to lead the way for the determination of structures of other human membrane proteins. The elucidation of more membrane protein structures will help us understand fundamental processes that take place in the cell membranes.

Facts: Proteins consist of a chain of amino acids.

The length of this chain can range from a few to thousands of amino acids. The chain is then folded in a characteristic way and the 3-D structure can bind different molecules.

Determining a protein structure and its biochemical characteristics helps us understand its function, and to design blocking or activating molecules which can serve as medicines. A known protein structure therefore makes it easier and faster to develop new pharmaceuticals.

The EU network EICOSANOX brings together leading scientists from Europe and Canada, and is coordinated by Karolinska Institutet.

Publication:

"Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase"
Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P.
Nature, AOP 15 July 2007

For more information, please contact:
Professor Jesper Z. Haeggstrom, coordinator for EICOSANOX

Karolinska Institutet is one of the leading medical universities in Europe. Through research, education and information, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine. For more information, visit http://ki.se/

Source: Professor Par Nordlund
Karolinska Institutet
 
 
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