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Recent News and Articles on the Keywords: treat alzheimer's + potential alzheimer's + curry  Related to the article below (Last Update: 7/1/2008)

Green tea antioxidant may help prevent Alzheimer's
Tehran Times, Iran - Jun 2, 2008
Strategies to prevent the development of amyloid plaque are one avenue being explored in the prevention and treatment of Alzheimer's. ...
In Vivo Detection of Apoptosis
RedOrbit, TX - Jun 25, 2008
Dysregulation of apoptosis results in the accumulation of unwanted cells, as in cancer or the premature removal of needed cells (such as in Alzheimer's ...
Breaking News from The Plain Dealer
The Plain Dealer - cleveland.com, OH - Jun 10, 2008
UCLA researchers found that mice fed curcumin had 80 percent fewer of the protein plaques associated with Alzheimer's disease than did mice on a normal diet ...
Source: Google News

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic … -
GP Lim, T Chu, F Yang, W Beech, SA Frautschy, GM … - Journal of Neuroscience, 2001 - neuroscience.org
... Potential mechanisms underlying these curcumin treatment effects are ... and NSAID
prophylactic for prevention or treatment of Alzheimer's and possibly other ...

A Potential Role of the Curry Spice Curcumin in Alzheimer?s Disease -
JM Ringman, SA Frautschy, GM Cole, DL Masterman, … - Current Alzheimer research, 2005 - pubmedcentral.nih.gov
... involved in the pathogenesis of Alzheimer?s disease ... 6, 7). Though there are many
potential explanations for ... curcumin in the prevention and treatment of human ...

Risk of Alzheimer's disease and duration of NSAID use -
WF Stewart - Neurology, 1997 - AAN Enterprises
... Van Leuven, and GE Landreth Acute treatment with the ... Oxidation in the Pathogenesis
of Alzheimer's Disease Am ... FM LAFERLA Microglia as a Potential Bridge between ...

[CITATION] Current drug targets for Alzheimer's disease treatment
DK Lahiri, MR Farlow, NH Greig, K Sambamurti - Drug Development Research, 2002
... We will briefly review the current state of knowledge in Alzheimer?s research, and
the potential basis for new diagnostic and treatment strategies for AD. ...

[CITATION] Chronic nicotine treatment reduces ?-amyloidosis in the brain of a mouse model of Alzheimer's … -
A Nordberg, E Hellstrom-Lindahl, M Lee, M Johnson, … - Journal of Neurochemistry, 2002 - Blackwell Synergy
... may inhibit the A accumulation and provide potential new treatment ... E. and Masters
CL, Bush AI (2001) Treatment with a ... in a mouse model for Alzheimer's disease. ...

Intraneuronal A?, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer?s … -
… , E Miranda, R Page, JA Curry, FAI Duthie, DC Gubb … - Neuroscience, 2005 - Elsevier
... KJ Kinghorn a , E. Miranda a , R. Page a , JA Curry c , FAI ... by a therapeutic
intervention that is effective in the treatment of human Alzheimer?s disease. ...

A Critical Analysis of New Molecular Targets and Strategies for Drug Developments in Alzheimer's … -
DK Lahiri, MR Farlow, K Sambamurti, NH Greig, E … - Current Drug Targets, 2003 - ingentaconnect.com
... the brain [31,32] are potential new therapeutic ... immunotherapeutic strategies for
prevention and treatment of AD ... 5. ALZHEIMER?S DISEASE: INVOLVEMENT OF SEVERAL ...

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease -
D Beher, SL Graham - Expert Opin. Investig. Drugs, 2005 - Expert Opinion
... Protease inhibitors as potential ... for Alzheimer?s disease ... The current lack of an effective
treatment for Alzheimer?s disease (AD) has fuelled an intense ...

Alzheimer?s associated inflammation, potential drug targets and future therapies -
G Stuchbury, G M?nch - Journal of Neural Transmission, 2005 - Springer
... Anti-inflammatory therapy in Alzheimer?s disease ... and in vitro, further indicating
its potential as a ... have demonstrated their promise as a treat- ment for AD ...

One-compound-multiple-targets strategy to combat Alzheimer?s disease -
HY Zhang - FEBS Letters, 2005 - Elsevier
... aminoindan and phenethylamine as potential treatment for Alzheimer ... new strategy to
combat Alzheimer?s disease ... Combining radical-scavenging potential with metal ...

Source: Google Scholar

Curry ; Potential To Treat Alzheimer's Isolated By Scientists
FINDINGS: Researchers isolated bisdemethoxycurcumin, the active ingredient of curcuminoids - a natural substance found in turmeric root - that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease. Using blood samples from Alzheimer's disease patients, researchers found that bisdemethoxycurcumin boosted immune cells called macrophages to clear amyloid beta. In addition, researchers identified the immune genes associated with this activity.

IMPACT: The study provides more insight into the role of the immune system in Alzheimer's disease and points to a new treatment approach. Researchers say that it may be possible to test a patient's immune response with a blood sample in order to individualize treatment.

The genes involved in the process, called MGAT III and Toll-like receptors, are also responsible for a number of other key functions in the immune system.

The results also suggest a new drug development approach for the disease that differs from the amyloid-beta vaccine. The new approach relies on the innate immune system, which is present at birth rather than on antibodies produced by B cells, which is a later developed part of the active immune system.

AUTHORS: Dr. Milan Fiala, a researcher with the David Geffen School of Medicine and the VA Greater Los Angeles Health Care System and Dr. John Cashman, director of the Human BioMolecular Research Institute (HBRI) in San Diego.

FUNDING: Cashman received study funding from the Alzheimer's Drug Discovery Foundation and Fiala from the Alzheimer's Disease Association.

JOURNAL: The research appears in the July 16 early edition of the Proceedings of the National Academy of Sciences.

Source: Rachel Champeau
University of California - Los Angeles

 
 
 
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