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Recent News and Articles on the Keywords: adversely affect + adversely affects + hiv  Related to the article below (Last Update: 5/12/2008)

American Pacific Reports Revenue Increase of 11% and Net Income of ...
Earthtimes (press release), UK - May 8, 2008
We have a substantial amount of debt, and the cost of servicing that debt could adversely affect our ability to take actions, our liquidity or our financial ...APFC
HLA-Omics and Cancer Biomarkers: Emerging Tools and Technologies ...
RedOrbit, TX - May 1, 2008
... pace with the ever-growing health need for the rapid and accurate diagnosis of the multitude of cancers that adversely affect the global population. ...OTC:CTHP
Source: Google News

Alcohol use and incarceration adversely affect HIV-1 RNA suppression among injection drug users … -
A Palepu, MW Tyndall, K Li, B Yip, MV O? … - Journal of Urban Health, 2003 - Springer
... to tolerate medication due to adverse effects, especially in ... on therapy, lower baseline
HIV-1 RNA ... mechanism by which alcohol adversely affects HIV- 1 treatment ...

… virus type 1 does not adversely affect outcome at 1 year. Sydney Primary HIV Infection Study Group. -
A Imrie, A Carr, C Duncombe, R Finlayson, J … - J Infect Dis, 1996 - ncbi.nlm.nih.gov
Primary infection with zidovudine-resistant human immunodeficiency virus type 1
does not adversely affect outcome at 1 year. Sydney Primary HIV Infection Study ...

… Mutant of CREB (cAMP Response Element-Binding Protein) Adversely Affects the Survival, but Not the … -
JP Somers, JA DeLoia, AJ Zeleznik - Molecular Endocrinology, 1999 - Endocrine Soc
... in granulosa cells may adversely affect cell proliferation ... to note that cytopathic
effects of CREB M1 ... exhibited nearly complete cytopathic effect and processed ...

HIV infection may adversely affect clinical response to chloroquine therapy for uncomplicated … -
MR Kamya, CN Kigonya, W McFarland - AIDS, 2001 - aidsonline.com
... HIV infection may adversely affect clinical response to chloroquine therapy
for uncomplicated malaria in children. [Research Letters]. ...

[PDF] … not a variety of HIV reverse transcriptase inhibitors, adversely affect human proteasome function -
M Piccinini, MT Rinaudo, A Anselmino, B Buccinna, … - Antivir Ther, 2005 - intmedpress.com
... inhibitors, adversely affect human proteasome function ... replication, reversal of
HIV-driven immune ... highlights direct immunomodulatory effects of antiretroviral ...

Race, Socioeconomic Status, and Health The Added Effects of Racism and Discrimination -
DR WILLIAMS - Annals of the New York Academy of Sciences, 1999 - Blackwell Synergy
... diabetes, cirrhosis of the liver, and HIV/AIDS than ... that in addition to its effects
on health ... and discrimination can also more directly adversely affect health ...

Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus … -
N Singh, C Squier, C Sivek, M Wagener, MH Nguyen, … - AIDS Care, 1996 - informaworld.com
... Studies in HIV suggest that psychosocial stress associated with the illness adversely
affects the quality of life in HIV patients (Fawzy et al., 1989; Holland ...

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell … -
P Andre, M Groettrup, P Klenerman, R de Giuli, BL … - Proc Natl Acad Sci US A, 1998 - pubmedcentral.nih.gov
... these inhibitors exert additional effects on the immune system. Our studies suggest
that the HIV-1 protease inhibitor ritonavir may adversely affect the CTL ...

Rapid Progression to AIDS in HIV+ Individuals with a Structural Variant of the Chemokine Receptor … -
S Faure, L Meyer, D Costagliola, C Vaneensberghe, E … - Science, 2000 - sciencemag.org
... 3 CR1 I249 M280 haplotype adversely affects HIV disease progression ... This suggests
that the effect of the CX 3 ... and CCR2-64I alleles, which have dominant effects. ...

[PDF] HIV/AIDS: Does it Increase or Decrease Growth in Africa? -
R Bonnel - ACT, Africa Department, Washington, DC, World Bank, 2000 - heart-intl.net
... To the extent that HIV/AIDS reduces the skilled labor force, it would adversely
affect the ability of ... Other effects that have been identified include a ...

Source: Google Scholar

HIV Protease Inhibitor Drugs May Adversely Affect The Scaffolding Of The Cell Nucleus
UCLA scientists, along with collaborators from Purdue University, have demonstrated that HIV protease inhibitors crucial drugs for HIV treatment block a cellular enzyme important for generating the structural scaffolding for the cell nucleus.

Published in the July 16 early edition of Proceedings of the National Academy of Sciences, these biochemical findings may offer insights into the side effects of HIV protease inhibitors, including metabolic syndrome and regional losses of some of the body's fat tissue. These side effects occur in up to one-third of patients taking anti-HIV drug regimens.
"We show, for the first time, that certain HIV protease inhibitor drugs directly inhibit an enzyme called ZMPSTE24, which is important for generating the structural scaffolding supporting the cell nucleus," said Catherine Coffinier, Ph.D., study author and an assistant researcher at the David Geffen School of Medicine at UCLA.

UCLA researchers added HIV protease inhibitors to cultures of mouse and human fibroblast cells. They found that the inhibition of ZMPSTE24 by the HIV protease inhibitor drugs led to an accumulation of prelamin A, which is a precursor to mature lamin A a key molecule in the structural scaffolding for the cell nucleus. ZMPSTE24 is a membrane-bound intracellular zinc metalloproteinase that is required for the conversion of prelamin A to mature lamin A.

Interestingly, researchers found that the accumulation of prelamin A was exaggerated in cells that contained half the normal amount of ZMPSTE24.

Genetic defects in ZMPSTE24 in humans lead to an accumulation of prelamin A and cause a host of disease phenotypes, including partial loss of body fat depots and metabolic syndrome.

"The fact that HIV protease inhibitors block ZMPSTE24 and have been associated with side effects similar to those observed with a genetic deficiency in ZMPSTE24 is intriguing," said Loren Fong, Ph.D., study author and an associate professor of medicine at the David Geffen School of Medicine at UCLA.

The UCLA research team is known for its work on progeria, a precocious aging syndrome. Progeria syndromes can be caused by genetic defects that interfere with the conversion of prelamin A to lamin A.

"Since HIV protease inhibitors interfere with the conversion of prelamin A to lamin A, we believe at least at a biochemical level that there is a link between progeria syndromes and HIV treatment regimens," Fong said.
There are many HIV protease inhibitors on the market. One of the next steps, according to Coffinier, is to determine whether the blocking of ZMPSTE24 activity and the accumulation of prelamin A is caused by every HIV protease inhibitor or only some of them.

All of the current studies were performed in cultured cells, not tissues from HIV-treated patients. In future studies, the UCLA team would like to assess the biochemical and pathological side effects of the HIV protease inhibitors in humans taking these medications.

"Ultimately, we would like to further explore why some HIV protease inhibitor-treated patients develop side effects while others do not," said Dr. Stephen Young, study author and a professor of medicine at the David Geffen School of Medicine at UCLA.

The UCLA team was assisted by the laboratory of Christine Hrycyna, an associate professor of chemistry at Purdue University. The collaboration was a natural fit, as Hrycyna and the UCLA team share a common interest in ZMPSTE24 processing.

The study was funded by the National Institutes of Health, the American Heart Association and the Progeria Research Foundation.

Other study authors include: Sarah E. Hudon of the department of chemistry at Purdue University, and Emily A. Farber and Sandy Y. Chang, both of the department of medicine, division of cardiology at the David Geffen School of Medicine at UCLA.

University of California, Los Angeles (UCLA)
924 Westwood Blvd., Ste. 350
Los Angeles, CA 90095
United States
http://www.ucla.edu
 
 
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