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Recent News and Articles on the Keywords: interaction between + dramatically lower + drugs  Related to the article below (Last Update: 5/5/2008)

Watergas - How water can burn
ZPEnergy - Apr 23, 2008
They actually fall apart because of the changes resulting in their underlying sustaining processes in interaction with the active vacuum. ...
Source: Google News

Interaction between glucocorticoid hormones, stress and psychostimulant drugs* -
M Marinelli, PV Piazza - European Journal of Neuroscience, 2002 - Blackwell Synergy
... evidence of the interaction between glucocorticoid and ... adrenalectomy selectively
and dramatically (> 50%) decreases ... in those with lower dopaminergic activity ...

Pharmacokinetic Interactions Between Efavirenz and Rifampicin in HIV-Infected Patients with … -
LF L?pez-Cort?s, R Ruiz-Valderas, P Viciana, A … - Clinical Pharmacokinetics, 2002 - pharmacokinetics.adisonline.com
... HIV infection, decreasing dramatically the mortality ... Lower efficacy is observed and
longer ... given the pharmacokinetic interactions between protease inhibitors ...

Interactions between recreational drugs and antiretroviral agents -
T Antoniou - The Annals of Pharmacotherapy, 2002 - Harvey Whitney Books
... already complex medication regimens dramatically increases the ... Table 3. Interactions
Between Antiretrovirals and ... Study Type Patients Interaction Recommendation ...

Information technology and industrial cooperation -
EK Clemons, MC Row - System Sciences, 1992. Proceedings of the Twenty-Fifth …, 1992 - ieeexplore.ieee.org
... through price and quantity only -- the lower bound of ... that there is a tradeoff between
information (coordinated ... to tailor operations to a specific interaction. ...

Pharmacokinetic interactions between herbal remedies and medicinal drugs -
C Ioannides - Xenobiotica, 2002 - ingentaconnect.com
... on a chronic basis, may increase dramatically the intake ... otherwise be consumed at
low levels through ... of a potentially fatal interaction between cylosporin and ...

Experimental and computational approaches to estimate solubility and permeability in drug discovery … -
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney - Advanced Drug Delivery Reviews, 2001 - Elsevier
... screen is always higher, sometimes dramatically so, than ... Operationally, we have ignored
a lower limit because ... to allow for the interactions between donor and ...

High-Resolution and High-Throughput Protocols for Measuring Drug/Human Serum Albumin Interactions … -
RL Rich, YSN Day, TA Morton, DG Myszka - Analytical Biochemistry, 2001 - Elsevier
... sample and have a relatively low throughput ... HSA interactions over traditional
interaction analysis techniques ... teractions to be monitored between unmodified reac ...

Clinical Significance of Pharmacokinetic Interactions Between Antiepileptic and Psychotropic Drugs -
E Spina, E Perucca - Epilepsia, 2002 - Blackwell Synergy
... A clinically relevant interaction also occurs between enzyme-inducing AEDs and ... after
a single oral dose were found to be reduced dramatically in patients ...

Tuberculosis and Race/Ethnicity in the United States Impact of Socioeconomic Status -
MF CANTWELL, MT Mc KENNA, EMc CRAY, IDAM ONORATO - American Journal of Respiratory and Critical Care Medicine, 1998 - Am Thoracic Soc
... alcoholism, incarceration, intravenous drug use, and ... Additional adjustment for
interaction between race/ethnicity ... that of whites, dramatically lower than the 5 ...

… from curdlan derivatives: characterization, anti-cancer drug release and interaction with a hepatoma … -
K Na, KH Park, SW Kim, YH Bae - Journal of Controlled Release, 2000 - Elsevier
... which begins to increase dramatically at a ... by increasing the hydrophobic interactions
between sulfonylurea (SU ... This hydrophobic interaction affected the drug ...

Source: Google Scholar

Exploiting interactions between food and drugs could dramatically lower the rapidly rising costs of several anticancer drugs, and perhaps many other medications, two cancer-pharmacology specialists suggest in a commentary in the July 16, 2007, issue of the Journal of Clinical Oncology.
University of Chicago oncologists Mark Ratain, MD, and Ezra Cohen, MD, call attention to the flip side of recent studies showing how certain foods can alter absorption or delay breakdown of precisely targeted anti-cancer drugs.

Instead of seeing such studies as highlighting a dosing problem, Ratain and Cohen argue that results like this one should point researchers toward a partial solution, a novel way to decrease medication costs while increasing benefits from these effective but expensive drugs.
The commentary was inspired by a study presented in June at the American Society for Clinical Oncology. Researchers from Dartmouth showed that taking the breast cancer drug lapatinib (TYKERB) with food instead of on an empty stomach as suggested on the label resulted in more of the drug being absorbed and available to treat the cancer.

Patients currently take five 250 mg lapatinib tablets on an empty stomach. The study found that taking the drug with a meal increased the bioavailability of the drug by 167 percent. Taking the drug with a high-fat meal boosted levels by 325 percent.

"Simply by changing the timing, taking this medication with a meal instead of on an empty stomach, we could potentially use 40 percent (or even less) of the drug," said Ratain. "Since lapatinib costs about $2,900 a month, this could save each patient $1,740 or more a month."

Topping off that meal with grapefruit juice, "which may also increase plasma concentrations" according to the package insert, could increase the savings to 80 percent, the authors suggest, "minus the cost of the food and juice."

"We expect the one 250 mg lapatinib pill accompanied by food and washed down with a glass of grapefruit juice may yield plasma concentrations comparable to five 250 mg pills on an empty stomach," Ratain said.

Such a "value meal," the authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhea."

Patients should NEVER launch such experiments on their own, the authors caution. Such food-drug combinations should be studied to assess the effects, note person-to-person variations, and enable physicians to predict how individual patients will take up and metabolize specific drugs in the presence of certain foods.

"The one thing that should not be anticipated is an efficacy study by lapatinib's sponsor," the authors write. Such studies could be mounted by other entities, however, such as the Federal government, other payers or advocacy groups.

Ratain and Cohen are currently conducting such a study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs.

Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grapefruit juice and common drugs, such as the statins, which taken daily by millions of people to prevent heart disease, we could save a fortune in drug costs," Cohen said. "And patients would get a little vitamin C to boot."

"The rapidly escalating price of medications (especially for cancer and other life-threatening diseases) has provided incentives to explore pharmacological approaches to lower the costs of drugs," Ratain and Cohen conclude.

"As we enter an era of 'targeted' anticancer agents with a monthly cost measured in thousands of dollars, we should view drug-drug or drug-food interactions as opportunities to lower costs."

University of Chicago Medical Center
MC 6063, 5841 S. Maryland Ave.
Chicago, IL 60637
United States
http://www.uchospitals.edu
 
 
 
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