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Recent News and Articles on the Keywords: rna interference + decision-making process + rna  Related to the article below (Last Update: 5/12/2008)

Knockdown of TFIIS by RNA silencing inhibits cancer cell ...
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RNA interference (RNAi) is a way to decrease expression of a specific gene without otherwise affecting the cell, and it therefore could be a very promising ...

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Team develops safe, effective RNA interference technique
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A team of researchers from MIT and Alnylam Pharmaceuticals has developed safe and effective methods to perform RNA interference, a therapy that holds great ...
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Two week ago, I reported that Nastech intended to change its name to MDRNA in order to emphasize RNA interference. Read my post on that topic here. ...
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Examine Gene Therapy Markets and Technologies Now!
Business Wire (press release), CA -
Gene therapy can now combined with antisense techniques such as RNA interference (RNAi), further increasing the therapeutic applications. ...
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Cequent Pharmaceuticals' Johannes Fruehauf, MD, Ph.D., to be ...
Earthtimes (press release), UK - Apr 30, 2008
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Business Wire (press release)
Alnylam to Webcast Presentation at the Rodman & Renshaw 5 th ...
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Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is applying its therapeutic expertise ...ALNY - RODM
Source: Google News

Early Single Cell Bifurcation of Pro-and Antiapoptotic States during Oxidative Stress -
VD Nair, T Yuen, CW Olanow, SC Sealfon - Journal of Biological Chemistry, 2004 - ASBMB
... must proceed through a decision-making process that ultimately ... RNA Interference?Custom
SMARTpool plus small interfering ... Total RNA was isolated from control PC ...

[BOOK] RNA Methodologies: A Laboratory Guide for Isolation and Characterization -
RE Farrell, RE Farrell Jr - 2005 - books.google.com
... 581 Applications of Differential Display 582 Troubleshooting mRNA Differential Display ...
Approach 608 shRNA Approach 608 DNA-Directed RNA Interference 610 Short ...

[PDF] An autonomous molecular computer for logical control of gene expression -
Y Benenson, B Gil, U Ben-Dor, R Adar, E Shapiro - Nature, 2004 - sysbio.harvard.edu
... active molecules such as RNA interference, and in ... RJ & Landweber, LF Molecular
computation: RNA solutions to ... J. Analysis of medical-decision making and the use ...
-

Use of Antisense Oligonucleotides in Functional Genomics and Target Validation -
LV Ravichandran, NM Dean, EG Marcusson - Oligonucleotides, 2004 - liebertonline.com
... a beginning of the drug discovery process are underscored ... the oligonucleotide action
site within the target mRNA. ... siRNA (a form of RNA interference [RNAi]), in ...

Post-transcriptional gene silencing in neurons -
HC Zeringue, M Constantine-Paton - Current Opinion in Neurobiology, 2004 - Elsevier
... in the organisms life cycle, the interference is required. ... simply as a result of
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Messenger RNA regulation: to translate or to degrade -
AB Shyu, MF Wilkinson, A van Hoof - The EMBO Journal, 2008 - nature.com
... mRNA silencing use different decision-making processes to determine ... EJC components
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… Differentiation Through a Combination of Embryonic Stem Cell Culture and RNA Interference -
N Izumi, T Era, H Akimaru, M Yasunaga, SI … - Stem Cells, 2007 - stemcells.com
... in combination with the RNA interference-mediated gene ... tools for investigating the
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Nested genes: Biological implications and use of AFM for analysis -
CW Gibson, NH Thomson, WR Abrams, J Kirkham - Gene, 2005 - Elsevier
... understanding of cellular decision making processes, leading to ... associated with rapid
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Target validation joins the pharma fold
DE Szymkowski - Targets, 2003 - Elsevier
... are essential to Wyeth's decision-making process, whereas differential ... 3. RNA
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Process biology: integrated genomics and bioinformatics tools for improved target assessment
JF Reidhaar-Olson, M Braxenthaler, J Hammer - Targets, 2002 - Elsevier
... assessment and assist in decision-making throughout the ... target identification; target
validation; process biology; RNA interference; siRNA; expression ...

Source: Google Scholar

RNA Interference Decision-Making Processes On A Molecular Level
"How does RNAi work?" Researchers across the world have been trying to answer this question for a number of years. Science has now come closer to finding the answer thanks to a research group headed by Prof. Renée Schroeder (MFPL) and Dr. Javier Martinez (IMBA) based at the Campus Vienna Biocenter. The group's results are being published today in the internationally renowned scientific journal CELL and underline the importance of Austrian RNA research, which is also supported by the Austrian Science Fund FWF.
RNA interference (RNAi) is a natural cellular defence and regulation mechanism which works by eliminating unwanted RNA molecules. Its potential for use in therapy was officially recognised last year with the presentation of the Nobel Prize in Physiology or Medicine. Indeed, the first treatments to be based on this mechanism are currently undergoing clinical testing. Nevertheless, the details of this process still require a great deal of further research and hence, offer potential for optimizing medical treatments based on it.

No Risc. No Fun

It is precisely this potential that a group at the Campus Vienna Biocenter recently tapped in order to clarify key details surrounding the efficiency of RNA interference. Lead scientist Dr. Stefan L. Ameres from the Max F. Perutz Laboratories (MFPL), Department for Biochemistry at the University of Vienna, explains "A key stage of RNA interference is the binding of the RNA that is to be cleaved by RISC, the RNA-induced silencing complex. Already a lot is known about the subsequent destruction of the target RNA by RISC, but we have only little insight into the initial determination as to which RNAs are bound and how exactly this happens. Working with the Institute for Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), we have succeeded in making considerable progress towards clarifying this process."

The team initially focussed on characterising the influence of the RNA structure. Variations of an RNA target molecule were created where the RISC binding site became increasingly difficult to access due to structural differences. Dr. Ameres comments on the findings from the experiment: "The results were very clear indeed. The less accessible the binding site, the less efficient the RISC-induced elimination of the target RNA. Based on this data, we concluded that RISC does not possess the means to change the structure of RNA molecules an important finding towards the effective application of RNAi."
Another result was equally important to the understanding of RNA interference. The strength of the interaction between target RNA and RISC must exceed a certain threshold in order to trigger initiation of the subsequent RNA elimination process. This result clearly indicates that RISC binds RNA in a more or less random process and that it is the strength of this bond that determines the subsequent fate of the RNA. "One way of looking at this is that, while binding its target RNA, RISC has to carry out a check to ensure that it is only certain RNAs that are destroyed," explains Dr. Ameres.

"Ph.D. Program" Career Opportunity

The publication of these results in the journal CELL highlights not just the quality of RNA research at the Max F. Perutz Laboratories (a joint establishment of the University of Vienna and the Medical University of Vienna), but also the high standard of training provided for young scientists in dedicated Ph.D. programs. The publication of these results is also the high point of Dr. Ameres' Ph.D. training, which he has now completed in just this type of program. In fact, a special "RNA Biology" Ph.D. program was established at the Campus Vienna Biocenter in June 2007 to ensure that RNA research there retains its leading position in the long term. The work of molecular biologist Prof. Renée Schroeder also contributed to this achievement. She supported the work of Dr. Ameres using the prize money from the "Wittgenstein Award" presented to her by the FWF in 2003, thereby making an important financial contribution to the continuation of RNA research at the Campus Vienna Biocenter.

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" Molecular Basis for Target RNA Recognition and Cleavage by human RISC"
S.L. Ameres. J. Martinez, R. Schroeder
CELL (2007). doi:10.1016/j.cell.2007.04.037
Universität Wien
Campus Vienna Biocenter 5
1030 Vienna, Austria
http://www.univie.ac.at

Austrian Science Fund FWF
 
 
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