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Recent News and Articles on the Keywords: washington university + news releases + news  Related to the article below (Last Update: 5/5/2008)


Market Wire (press release)
Alpha Kappa Alpha to Hold Centennial Convention July 11-18
Market Wire (press release) -
The biennial convention, which will be held at the Washington Convention Center, represents the culmination of a journey that began on January 15, ...

Environment News Service
EPA Petitioned to Stop Sale of 260 Products Containing Nano-Silver
Environment News Service - May 2, 2008
A study from Arizona State University published in April showed that washing socks treated with silver nanoparticles to reduce foot odor releases most of ...
Mansfielder accepts Washington internship with Sherrod Brown
Mansfield News Journal, OH - May 3, 2008
Bryant will stay at George Washington University during his internship at a cost of $217 a week. While he has received some sponsorship donations from the ...

Boston Globe
Southeast counteracts efforts to reduce air pollution
The Tennessean, TN -
Brown, who has sued various entities to hold them accountable for the impact of their growth on California's greenhouse-gas releases, acknowledges that ...
State by state, communities take lead in warming fight Boston Globe
all 6 news articles »
Fuel for thought
Trading Markets (press release), CA - May 4, 2008
Biodiesel releases more energy than it consumes in its production, contrasting with pure diesel that requires more energy to produce than it yields, ...
Compiled by TABBY DORSEY of the Journal Star
Peoria Journal Star, IL - May 3, 2008
Releases must include your name and daytime telephone number. Send to Music & Arts, c/o Sunday Department, Journal Star, 1 News Plaza, Peoria, IL 61643. ...
Movers & Shakers (May 5)
Corvallis Gazette Times, OR -
Nielsen is a licensed CPA in Oregon and Washington. She previously worked at the University of Oregon as assistant director of quality assurance. ...
State of Blogging
RedOrbit, TX - May 3, 2008
... comments remains important: "Without comments, a blog is just a glorified press release," says Professor Mike Cornfield of George Washington University. ...
John Schreck puts a local face on pursuit of peace
Lancaster Newspapers, PA - May 3, 2008
He sends press releases to local media and designs the LCPJ's bimonthly newspaper, the Lancaster Voice. Schreck, a Millersville University graduate and ...
On shaky ground? Repeat of disastrous 1811-12 earthquakes always a ...
The Southern, IL - May 4, 2008
Energy becomes stored in different ways under each fault system, and when this energy releases, the vibration felt on the surface becomes an earthquake. ...
Source: Google News

Why firms voluntarily disclose bad news
D Skinner - Journal of Accounting Research, 1994 - JSTOR
... the Ohio State University, Purdue Uni- versity, Washington University in St ... Louis,
and Yale University, and especially two anon ... 16% for the good news releases). ...

Expression of cell-cycle regulators p 27 Kip 1 and cyclin E, alone and in combination, correlate … -
PL Porter, KE Malone, PJ Heagerty, GM Alexander, LA … - Nature Medicine, 1997 - nature.com
... 2 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer
Research Center, University of Washington, Seattle, Washington 98109, USA. ...

Secreted amyloid bold beta- protein similar to that in the senile plaques of Alzheimer's disease … -
D Scheuner, C Eckman, M Jensen, X Song, M Citron, … - Nature Medicine, 1996 - nature.com
... | PubMed | ChemPort |; Cai, XD, Golde, TE & Younkin, SG Release of excess ... University
of Washington Alzheimer's Disease Patient Registry (ADPR): 1987-1988. ...

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death -
MC Wei, WX Zong, EHY Cheng, T Lindsten, V … - Science, 2001 - sciencemag.org
... to tBID-induced cytochrome c release and apoptosis. ... 5 Department of Pathology,
Washington University School of ... News Focus: The Mitochondrion: Is It Central to ...

[CITATION] News influence on our pictures of the world
M McCombs, A Reynolds - Media effects: Advances in theory and research, 2002

The sociology of news production -
M Schudson - The social meaning of news: A text reader, 1997 - books.google.com
... Washington, DC: Brookings Institution. Hughes, HM (1940) News and the Um
uan Interrst Story. Chicago: University of Chicago Press. ...

Mapping genes for human personality -
CR Cloninger, R Adolfsson, NM Svrakic - Nature Genetics, 1996 - nature.com
... 1 Departments of Psychiatry and Genetics, Washington University School of Medicine,
4940 ... 2 Department of Psychiatry, University of Ume , Sweden. ... in the press. ...

Identification of protein coding regions by database similarity search -
W Gish, DJ States - Nature Genetics, 1993 - palgrave-journals.com
... Present address: Institute for Biomedical Computing, Washington University, 700
S ... NCBI News 1 (3), 6 (1992 ... ISI | ChemPort |; Entrez CD ROM Pre-release 6 (National ...

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT 3 and ILT … -
CC Chang, R Ciubotariu, JS Manavalan, J Yuan, AI … - Nature Immunology, 2002 - palgrave-journals.com
... 2 Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA.
3 Washington University, School of Medicine, St. Louis, MO 63110, USA. ...

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic … -
H Inoue, Y Tanizawa, J Wasson, P Behn, K Kalidas, … - Nat Genet, 1998 - nature.com
... 2 Department of Internal Medicine, Division of Endocrinology, Diabetes and
Metabolism,Washington University School of Medicine, St. Louis, Missouri, USA. ...

Source: Google Scholar

To Itch or Not to Itch? It's in the Genes

Finding could lead to targeted remedies for chronic scratching

 

(SOURCE: University of Washington School of Medicine in St Louis, news release, July 25, 2007)

THURSDAY, July 26 (HealthDay News) -- Researchers at the University of Washington School of Medicine in St Louis were scratching their heads over the genetic roots of pain when they stumbled on GRPR, the gene for itchiness.

The discovery could lead to more targeted remedies for chronic itching caused by everything from eczema to liver and kidney diseases.

GRPR codes for a receptor found in a small group of spinal cord nerve cells where pain and itch signals are transmitted from the skin to the brain. Mice who do not have this gene scratch less in the presence of known itch-inducers, the researchers found.

raditionally, researchers have had a greater interest in the genetic underpinnings of pain than of itching.

"Many genes have been identified in the pain pathway," lead researcher Zhou-Feng Chen, said in a prepared statement. "But itch research has lived in the shadow of pain research, and no one knew which gene was responsible for itching in the brain or in the spinal cord, until now."

Chronic itching is a widespread problem. Skin disorders such as eczema, illnesses such as kidney failure or liver disease, and cancer therapies and powerful painkillers such as morphine can all lead to itchiness. For some people, itching is bad enough to interfere with sleep or result in scarring from scratching. Effective treatment options for itchy patients are limited.

Writing in the July 25 online issue of Nature, Chen and his team describe research that came about as a result of an effort to find genes in the pain pathway. They identified GRPR as a potential candidate and performed studies on mice missing GRPR in comparison to normal mice.

Although they saw no difference between the mice in terms of pain response, they found a striking change when the mice were presented with itchy substances. While normal mice scratched vigorously, those lacking GRPR scratched little if at all.

The researchers also injected a substance that stimulates the GRPR gene and witnessed an increase in scratching behavior

In the long term, the research results suggest a way to develop anti-itch medication that does not dull pain response. In fact, the researchers noted that there are already pharmaceuticals in the pipeline that could help ease itching.

"Scientists have been studying [the GRPR] receptor for more than a decade," Chen said. "One interesting thing they've found is that GRPR is implicated in tumor growth. As a result of research like this, a lot of substances have been made that block the activity of GRPR. So now, researchers can study the effect of these agents on the itch sensation and possibly move that research to clinical applications fairly soon."

More information

To learn more about itching and the conditions that cause it, visit the U.S. National Institutes of Health.

 
 
 
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