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Recent News and Articles on the Keywords: peyronie's disease + slow progression + verapamil  Related to the article below (Last Update: 5/12/2008)

Penile Traction Therapy For Treatment Of Peyronie's Disease: A ...
Medical News Today (press release), UK - May 10, 2008
... the combination of penile traction therapy and intralesional drugs may offer both accelerated and improved outcomes for Peyronie's patients. ...
Education Helps Improve Quality Of Life For Patients With ...
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Peyronie's disease, a connective tissue disorder in which fibrous plaques develop in the soft tissue of the penis, occurs in about 1% of men. ...
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CNNMoney.com - May 7, 2008
... of Dupuytren's contracture and is in phase II of development for the treatment of Peyronie's disease and Frozen Shoulder syndrome (Adhesive Capsulitis). ...AUXL - BAC

Business Wire (press release)
World-Renowned Peyronie?s Disease Specialist, Dr. Culley Carson to ...
Business Wire (press release), CA - Apr 13, 2008
Recent demographic surveys have reported that Peyronie's disease, also known as penile curvature, can be found in up to nine percent of men between the ages ...
Auxilium Pharmaceuticals, Inc. Announces First Quarter 2008 ...
CNNMoney.com - Apr 30, 2008
We also continue to expect initiation of a phase IIb trial of XIAFLEX for Peyronie's disease by the end of the second quarter of 2008," said Armando Anido, ...AUXL
He's out of shape
Sunday Mirror, UK - Apr 26, 2008
It sounds like your husband is suffering from Peyronie's disease. This occurs when a fibrous band of scar tissue forms on one side of the penis, ...
Source: Google News

Intralesional verapamil for the treatment of Peyronie's disease: a review -
LA Levine, CR Estrada - International Journal of Impotence Research, 2002 - nature.com
... options have been used for Peyronie's disease (PD) including ... may have the capacity
to slow, prevent, or even reverse plaque formation and the progression of PD ...

Management of Peyronie's disease-a review -
HSGR Tunuguntla - World Journal of Urology, 2001 - Springer
... a more gradual onset and slow progression of the ... stable disease in 47%, and progression
in 40 ... Peyronie's disease is an acquired condition probably resulting ...

News from the American Urological Association meeting.
S Sullivan - Inpharma Weekly, 2005 - inpharma.adisonline.com
... JP, Guhring P, Depierro C.Intralesional verapamil prevents progression of Peyronie's
disease. ... 5. Mattos RM, Lucon AM.Tadalafil and slow-release fluoxetine ...

… , and Topical Magnesium Sulfate for the Treatment of Peyronie's Disease-A Placebo-Controlled Pilot …
F Password - Journal of Sexual Medicine, 2007 - Blackwell Synergy
... could ameliorate or just prevent progression would be a ... scar remodeling is an extremely
slow process taking ... even slower in the patient with Peyronie's disease? ...
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Combination Nonsurgical Therapy
V Mirone - Peyronie's Disease: A Guide to Clinical Management, 2007 - books.google.com
... in variable ways, ranging from slow or fast ... operative treatment to stabilize the
progression of PD. ... shock wave therapy for Peyronie's disease: exploratory meta ...
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Conservative management options for peyronie?s disease -
GS Jack, N Gonzalez-Cadavid, J Rajfer - Current Urology Reports, 2005 - Springer
... once thought to entail a slow, spontaneous resolution. ... the disorder and prevent
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10 Combination Nonsurgical Therapy -
V Mirone - Peyronie's Disease: A Guide to Clinical Management, 2007 - Springer
... history can develop in variable ways, ranging from slow or fast ... T, Weidner W.
Extracorporeal shock wave therapy for Peyronie?s disease: exploratory meta ...
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Priapism, Peyronie?s Disease, Penile Reconstructive Surgery
JP UK, E Akkus, T Lebret, S Perovic, DR UK, W … - issm.info
... Reaspiration Slow aspiration to maintain detumescence and reoxygenation Inject a ...
Peyronie's disease is named after the French physi- cian Francois Lapeyronie ...
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Erectile Dysfunction
A Vinik, D Richardson - doi.wiley.com
... deep slow (6 breaths=minute) respiration ... Vascular disease is usually manifested by
buttock claudication but may ... of ED is made by a logical stepwise progression. ...

Original Research -
C Reference - The Ochsner Journal, 2007 - ochsnerjournal.org
... R38 PORCINE SIS GRAFTS VS AUTOLOGOUS DERMAL GRAFTS IN THE SURGICAL MANAGEMENT
OF PEYRONIE'S DISEASE: A COMPARATIVE STUDY Return to TOC. ...

Source: Google Scholar

Verapamil can slow Peyronie's disease progression

Last Updated: 2007-07-26 10:54:42 -0400 (Reuters Health)

By Martha Kerr

NEW YORK (Reuters Health) - Injections of verapamil directly into the penis in patients with Peyronie's disease resulted in a reduction in curvature of the penis in 18 percent of the patients and disease stabilization in 60 percent, according to the results of a new study.

 

Described in the18th century by French physician Francois Gigot de la Peyronie, Peyronie's disease is an inflammatory condition caused by the build-up of plaque or scar tissue beneath the skin of the penis. This results in curvature, pain and impaired sexual performance, according to the American Urological Association.

Symptoms of Peyronie's disease vary widely, but painful erections and difficult intercourse are usually the reasons patients seek medical help, the AUA says. The condition is estimated to affect 4 out of 100 men, but because many men are reluctant to discuss it, the number may be higher.

Peyronie's disease is usually treated with oral medications and local drug injections for the first few months. Surgery may be considered for men who do not respond to these treatments and for the most severe cases.

In a study published in the medical journal Urology, Dr. John P. Mulhall and colleagues at Weill Medical College of Cornell University, New York, investigated the impact of injecting verapamil the into the penile plaque in 94 men with Peyronie's disease.

Verapamil is a heart drug used to treat irregular heartbeats, high blood pressure and chest pain (angina). It relaxes the blood vessels, increasing the supply of blood and oxygen.

The average patient age was 44 years old and the average duration of disease was 5.7 months. All of the men had penile curvature. They received six injections of verapamil given two weeks apart.

At follow-up 5.2 months after the last injection, which was approximately one year after disease onset, the researchers found that 18 percent of men had improvements in penile curvature, 60 percent had no disease progression and 22 percent had a worsening of disease.

These numbers are "significantly improved over the number who had stable deformity in our natural history database," the Cornell team writes. The study also demonstrated the safety of the procedure.

Mulhall told Reuters Health that if patients consult the doctor during the early stage of this condition, they have a 50 percent chance that the penile deformity will not become worse.

"Nobody knows exactly how this treatment actually works," he added. "It is possible that the needle or saline that the verapamil is in are just as important as the drug."

SOURCE: Urology, June, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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