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Recent News and Articles on the Keywords: reduced craving + cocaine craving + cocaine  Related to the article below (Last Update: 5/12/2008)


Times of Wayne County
The High Price to..Crack Cocaine..
Times of Wayne County, NY - May 11, 2008
In addition to the 20 day rule of thumb, a crack addict, without a very strong support system, will hit yet another craving wall six months out of any ...
Epic Genetics: Genes? chemical clothes may underlie the biology ...
Science News - May 9, 2008
But sometimes holding on to a program can be just as harmful, especially if that programming spurs a craving for cocaine or leads to obsessive hand washing ...
Source: Google News

Cocaine-induced cocaine craving -
JH Jaffe, NG Cascella, KM Kumor, MA Sherer - Psychopharmacology, 1989 - Springer
... general malaise, could have non-specifically reduced desire for ... min after administra-
tion of cocaine intravenously, self-ratings of "craving" and "wanting ...

… opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving -
JK Zubieta, DA Gorelick, R Stauffer, HT Ravert, RF … - Nature Medicine, 1996 - nature.com
... Decreased dopamine D2 receptor availability is associated with reduced frontal
metabolism ... G. & Crea, G. The measurement of craving in cocaine patients using ...

[PDF] Risperidone Decreases Craving and Relapses in Individuals with Schizophrenia and Cocaine Dependence -
M Kaune, J Williams, D Ziedonis - Can J Psychiatry, 2002 - server03.cpa-apc.org
... Page 2. haloperidol and fluphenthixole reduced craving and relapses in both
schizophrenia and nonschizophrenia cocaine- dependent patients (13?15). ...
-

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects -
ND Volkow, GJ Wang, JS Fowler, J Logan, SJ Gatley, … - Nature, 1997 - nature.com
... where the nucleus accumbens is located, and also had a reduced 'high' relative ... This
thalamic response was associated with cocaine craving and was not seen in ...

Tryptophan depletion and attenuation of cue-induced craving for cocaine. -
SL Satel, JH Krystal, PL Delgado, TR Kosten, DS … - Am J Psychiatry, 1995 - ncbi.nlm.nih.gov
... to cocaine-craving cues while their 5-HT levels were lowered and during a placebo
condition in a counterbalanced, double-blind design. 5-HT levels were reduced ...

Quetiapine in bipolar disorder and cocaine dependence -
ES Brown, VA Nejtek, DC Perantie, L Bobadilla - Bipolar Disorders, 2002 - Blackwell Synergy
... and BPRS scores were significantly reduced during the ... Drug cravings significantly
decreased as indicated by the ... Dollar amount spent on cocaine, days of cocaine ...

A role for sensitization in craving and relapse in cocaine addiction -
PW Kalivas, R Chris Pierce, J Cornish, BA Sorg - Journal of Psychopharmacology, 1998 - jop.sagepub.com
... while the changes derived from learning may provide more critical underpinnings
for cocaine craving and ... Absolutely no craving for the further use of cocaine ...

… dopamine D 2 receptor availability is associated with reduced frontal metabolism in cocaine abusers -
ND Volkow, JS Fowler, GJ Wang, R Hitzemann, J … - Synapse, 1993 - doi.wiley.com
... Availability Is Associated With Reduced ... Depression inventory scale, and an analog
scale (scored from 0 to 10) was used to quantify cocaine craving during the ...

A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent … -
MS Reid, JD Mickalian, KL Delucchi, SP Berger - Neuropsychopharmacology, 1999 - ncbi.nlm.nih.gov
... The cue-induced increase in cocaine craving was reduced, while the cue-induced skin
conductance and temperature responses were unaffected, by mecamylamine. ...

Incubation of cocaine craving after withdrawal: a review of preclinical data -
L Lu, JW Grimm, BT Hope, Y Shaham - Neuropharmacology, 2004 - Elsevier
... Author Keywords: BDNF; Craving; Cocaine cues; Extinction; Incubation; Glutamate
receptors; Neuroadaptations; Priming; Reinstatement; Relapse; Review; Sucrose ...

Source: Google Scholar

Cocaine craving may be reduced by N-acetylcysteine

Last Updated: 2007-07-26 13:53:13 -0400 (Reuters Health)

By Will Boggs, MD

 

NEW YORK (Reuters Health) - New evidence suggests that treatment with N-acetylcysteine can suppress the reaction to cues that stimulate drug-craving in individuals who are addicted to cocaine, according to findings published in the American Journal of Psychiatry.

"We may have a completely new pharmacological mechanism for treating cocaine addiction and perhaps other addictive disorders," Dr. Peter W. Kalivas from the Medical University of South Carolina, Charleston told Reuters Health.

N-acetylcysteine has been used as a mucus-dissolving therapy in patients with respiratory conditions, as a treatment for acetaminophen overdose, and to protect the kidneys from damage by contrast agents used during X-ray imaging studies.

Other uses of N-acetylcysteine that have been investigated include prevention and treatment of cancer, and as an anti-HIV drug.

Kalivas and colleagues assessed the effects of N-acetylcysteine on cue-induced cocaine-craving in a study of 15 addicted individuals.

The researchers found that N-acetylcysteine treatment decreased the patients' rating scores for craving, desire to use, and interest evoked by depictions of cocaine use on photographic slides.

N-acetylcysteine has the potential to "dampen cravings, promote cognitive therapy, and thereby inhibit the vulnerability to relapse in addicts," Kalivas said. "This will involve daily use."

N-acetylcysteine is active in stabilizing the addiction-associated abnormalities of glutamate transmission, he observed. "Even if N-acetylcysteine proves not as useful as we hope, it is the first in what may be a line of compounds with related pharmacological actions."

Another study is being conducted to evaluate the effect of N-acetylcysteine on relapse rates, Kalivas added, and pilot clinical trials are examining the effects of N-acetylcysteine on craving in nicotine and marijuana addiction.

SOURCE: American Journal of Psychiatry, July 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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