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Recent News and Articles on the Keywords: jim erickson + 734) 647-1842 + contact  Related to the article below (Last Update: 5/12/2008)

Tribute to local photography legend, Jim Erickson
Devil's Lake Daily Journal, ND - May 8, 2008
By Mike Bellmore - Features Editor Jim Erickson, a Devils Lake legend in the photography business, passed away this week at his Plymouth, Minn. home. ...
Mannix drops a bomb on Erickson
The Oregonian - OregonLive.com, OR -
... and at this point it could be effective," said Jim Moore, who teaches political science at Pacific University. "Erickson is going to be hard pressed to ...
Monday, May 12, 2008 12:19 PM CDT
Chippewa Herald, WI -
Jeana Bischel, Gregory Childs, Carolyn Cristallo, Nicholas Erickson, Melvin Lorenz, Scott Mancl, Dennis Strabley, Cory Vetterkink. 1:30 pm State vs. ...
Wisconsin lawmakers reach deal on $527M budget shortfall
Wausau Daily Herald, WI -
Jim Doyle?s spokeswoman Jessica Erickson had no immediate comment. Doyle had warned that without a deal by Tuesday, up to $260 million in bids for summer ...
Benicia council discusses Seeno project
Vallejo Times-Herald, CA - May 7, 2008
"With those conditions and changes, we think this project could be and should be approved," City Manager Jim Erickson said.
Wis. lawmakers reach deal on $527M budget gap
Forbes, NY -
Jim Doyle's spokeswoman Jessica Erickson had no immediate comment. Doyle had warned that without a deal by Tuesday, up to $260 million in bids for summer ...
Local sports notes
Superior Telegram, MN - Apr 28, 2008
25s ? Dave Compton, Jens Gregerson III, Alex Kotter, Darrel Blaylock, Joe Rady, Dan Thompson, Jim Erickson, Rick Washkuhn, Ralph Rolson II, Frank Kacsir, ...
Local Names & News Duluth News Tribune
all 3 news articles »
Career Track
Florida Times-Union, FL - May 11, 2008
By The Times-Union - CPA firm Presser, Lahnen & Edelman has announced the addition of staff accountants, Jeriame Erickson and Stacey Hobson. ...
Benicia wants cable choice
San Jose Mercury News,  USA - May 10, 2008
... that the company will abide by the same rules as Comcast, including providing geographically comprehensive coverage, said City Manager Jim Erickson. ...
Public gives Courson its support
Orlando Sentinel, FL - May 11, 2008
During the fall campaign season, DeBary City Council members Norm Erickson and Lenny Marks told voters that the city manager misled and controlled the ...
Source: Google News

Lysophosphatidic acid is a bioactive mediator in ovarian cancer -
… JL Tanyi, R LaPushin, A Eder, R Jaffe, J Erickson … - BBA-Molecular and Cell Biology of Lipids, 2002 - Elsevier
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that exhibits
pleiotrophic biological activities, ranging from rapid morphological changes to
long-term cellular effects such as induction of gene expression and ...

C3 Toxin Activates the Stress Signaling Pathways, JNK and p38, but Antagonizes the Activation of AP- … -
J Beltman, JR Erickson, GA Martin, JF Lyons, SJ … - Journal of Biological Chemistry, 1999 - ASBMB
Lysophosphatidic acid (LPA) stimulates the c-Fos serum response element (SRE) by
activating two distinct signal pathways regulated by the small GTPases, Ras and
RhoA. Ras activates the ERK cascade leading to phosphorylation of the ...

" I'd be overwhelmed, but it's just one more thing to do": availability and interruption in research … -
JM Hudson, J Christensen, WA Kellogg, T Erickson - Proceedings of the SIGCHI conference on Human factors in …, 2002 - portal.acm.org
ABSTRACT Many CSCW projects dealing with individual availability and
interruption filtering achieve only limited success. Perhaps this is because
designers of such systems have limited evidence to draw upon; most data on ...

Comprehensive Approach toward Understanding Element Speciation and Leaching Behavior in Municipal … -
… , DS Domingo, D Staempfli, JR Martin, PM Erickson - Environmental Science & Technology, 1995 - pubs.acs.org
T. TAYLOR EIGHMY,L,t J . DYKSTRA EUSDEN, JR . , * JAMES E. KRZANOWSK1,s DAVID S.
DOMINGO,t DOMINIQUE STAMPFLI,+ JOHN R . MARTIN,"sL AND PATRICIA M . ERICKSONA
Environmental Research Group, A1 15 Kingsbury Hall, University of New ...

Specific Keynote: Molecular Therapeutics in Ovarian Cancer -
… , Y Nakayama, W Kuo, J Erickson, D Gershenson, EC … - Gynecologic Oncology, 2003 - Elsevier
Ovarian cancer, like all cancer, is a disease of genes. The changes in gene
function in cancer cells can be due to genetic mechanisms such as mutation,
translocation, and increased or decreased copy number or to epigenetic ...

[CITATION] I?d be overwhelmed, but it?s just one more thing to do
JM Hudson, J Christensen, WA Kellogg, T Erickson - Availability and Interruption in Research Management. Proc. …, 2002

Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies -
… PM Fitzpatrick, J Mertz, SB Erickson, S Liggett, S … - Nephrology Dialysis Transplantation, 2004 - ERA-EDTA
Methods. We conducted a study to examine the efficacy and safety of rapamycin in
patients with progressive chronic renal failure. Eleven patients with either
focal segmental glomerulosclerosis, immunoglobulin A nephropathy, ...

[PDF] Mars Exploration Rover: launch, cruise, entry, descent, and landing -
JK Erickson, RM Manning, M Adler - 55th International Astronautical Congress, Vancouver, Canada …, 2004 - trs-new.jpl.nasa.gov
The Mars Exploration Rover Project was an ambitious effort to land two highly
capable rovers on Mars and concurrently explore the Martian surface for three
months each. Launched in June and July of 2003, cruise operations were ...

Intergeneric hybridization between Sinapis alba and Brassica napus -
J Brown, AP Brown, JB Davis, D Erickson - Euphytica, 1997 - Springer
Researchers have conclusivelyshown that Sinapis alba (commonlyknown as yellow
mustard) has many agronomic traits which would be beneficial if transferred to
rapeseed (Brassica napus L.). S. alba is resistant or tolerant to all major ...

Epidemiological and economic burden of pneumococcal diseases in Canadian children -
… , P De Wals, B Law, T Tam, LJ Erickson, M Guay, A … - The Canadian Journal of Infectious Diseases, 2003 - pubmedcentral.nih.gov
Cumulative risks were one in 5000 for pneumococcal meningitis, one in 500 for
bacteremia and one in 20 for pneumonia, leading to 16 deaths in the cohort.
About 262,000 otitis media episodes and 32,000 cases of myringotomy with ...

Source: Google Scholar

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan

U-M team identifies gene that regulates blood-forming fetal stem cells

ANN ARBOR, Mich. -- In the rancorous public debate over federal research funding, stem cells are generally assigned to one of two categories: embryonic or adult. But that's a false dichotomy and an oversimplification. A new University of Michigan study adds to mounting evidence that stem cells in the developing fetus are distinct from both embryonic and adult stem cells.

In the last several years, stem cell researchers have realized that fetal stem cells comprise a separate class. They recognized, for example, that fetal blood-forming stem cells in umbilical cord blood behave differently than adult blood-forming stem cells after transplantation into patients.

Now a U-M team led by Sean Morrison has identified the first known gene, Sox17, required for the maintenance of blood-forming stem cells in fetal mice, but not in adult mice. The discovery provides a critical insight into the mechanisms that distinguish fetal blood-forming stem cells from their adult counterparts.

The findings could also lead to a deeper understanding of diseases such as childhood leukemias, said Morrison, director of the U-M Center for Stem Cell Biology and a Howard Hughes Medical Institute investigator. Childhood leukemias are cancers that afflict blood-forming cells and hijack normal stem cell self-renewal mechanisms.

"One of the next questions in our cross hairs is whether Sox17 gets inappropriately activated in certain childhood leukemias---and that's an idea that nobody had in their mind before this work," Morrison said. "If it's true, it'll give us a new target for cancer."

The Sox17 results will be published online July 26 in the journal Cell. U-M's Injune Kim is lead author of the paper; Morrison and U-M's Thomas Saunders are co-authors.

"Identification of Sox17 could also facilitate efforts to form blood-forming stem cells from human embryonic stem cells, a goal that could enhance bone marrow transplantation," Kim said.

The Sox 17 study is part of a larger, ongoing U-M effort to understand how stem cells are regulated at different stages of life. Last September, Morrison's team reported that old stem cells don't simply wear out; a gene called Ink4a actively shuts them down.

"Each time we identify one of these genes, we get a new insight into what stem cells really are, what regulates their identity and how their age-specific functions work," Morrison said. That information could lead to new treatments for degenerative diseases.

Stem cells generate all of the tissues in the developing human body and later in life provide replacement cells when adult tissues are damaged or wear out. Stem cells that form blood and immune-system cells are called hematopoietic stem cells.

In the latest study, Kim and Morrison looked for genes required to maintain hematopoietic stem cells in fetal mice, but not in adult mice. They found that Sox17 was turned on in fetal and neonatal hematopoietic stem cells but not adult hematopoietic stem cells.

To test whether Sox17 was functionally important for fetal and neonatal blood-forming stem cells, the researchers deleted the Sox17 gene in laboratory mice. This led to the loss of fetal and neonatal, but not adult, hematopoietic stem cells.

In follow-up experiments, mice were irradiated to destroy their blood-forming stem cells. Then replacement fetal or neonatal blood-forming cells were transplanted into the mice---some containing the Sox17 gene and others lacking it. The mice that received Sox17-bearing cells were able to regenerate their blood systems. Those that received cells lacking Sox17 could not.

"Sox17 is really a critical player," Morrison said. "If you knock it out in mice, they never develop a blood system. They never form blood cells."

###

The University of Michigan
News Service
412 Maynard
Ann Arbor, MI 48109-1399

EMBARGOED FOR RELEASE AT NOON EDT THURSDAY, JULY 26, 2007

Links:

U-M Center for Stem Cell Biology: http://lsi.umich.edu/facultyresearch/centers/stemcellbiology

Sean Morrison: http://www.ns.umich.edu/htdocs/public/experts/ExpDisplay.php"ExpID=949

Morrison lab: http://lsi.umich.edu/facultyresearch/labs/Morrison
 
 
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