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Recent News and Articles on the Keywords: protein synthesis + new protein + new  Related to the article below (Last Update: 5/12/2008)

Getting Wise To Influenza Virus' Tricks: Imaging Of Influenza ...
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However, in all circumstances the prerequisite for muscle protein synthesis is dietary derived amino acids (40). Several studies have demonstrated an acute ...
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all 8 news articles »
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Preclinical services news in brief
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Alalam News Network
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Nature.com (subscription)
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Source: Google News

… granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease … -
JB Schulz, M Weller, T Klockgether? - J Neurosci, 1996 - Soc Neuroscience
... B. Wagenknecht, J. Dichgans, and M. Weller Betulinic Acid-Induced Apoptosis in Glioma
Cells: A Sequential Requirement for New Protein Synthesis, Formation of ...

(-)-Deprenyl Reduces PC12 Cell Apoptosis by Inducing New Protein Synthesis -
WG Tatton, WYL Ju, DP Holland, C Tai, M Kwan - J. Neurochem., 1994 - Blackwell Synergy
... New Protein Synthesis *#WG Tatton, *tW . ... MAO-B inhibition but rather results from
the induction of new protein synthesis by (-)-deprenyl. MATERIALS AND METHODS ...

cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis -
S Schacher, VF Castellucci, ER Kandel - Science, 1988 - sciencemag.org
... articles. cAMP evokes long-term facilitation in Aplysia sensory neurons that requires
new protein synthesis. S Schacher, VF Castellucci, and ER Kandel ...

… receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis … -
AM Marini, SM Paul - Proc Natl Acad Sci US A, 1992 - pubmedcentral.nih.gov
... Copyright notice. N-methyl-D-aspartate receptor-mediated neuroprotection in
cerebellar granule cells requires new RNA and protein synthesis. ...

[PDF] Protein content and protein synthesis rates of planktonic marine bacteria. -
M Simon, F Azam - Marine ecology progress series. Oldendorf, 1989 - int-res.com
... 3,4,5-3H]-1- leucine (140 Ci mmol-l, New England Nuclear ... of the added leucine, and
(b) maximize leucine uptake and hence its participation in protein synthesis. ...

Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific … -
TK Sampath, JC Maliakal, PV Hauschka, WK Jones, H … - Journal of Biological Chemistry, 1992 - ASBMB
... hOP-1 was capable of inducing new bone formation ... by highly purified bovine osteogenic
protein preparations ... effects on cell growth and collagen synthesis in rat ...

… Activity of Group-II Metabotropic Glutamate Receptors Requires New Protein Synthesis and Involves a … -
V Bruno, FX Sureda, M Storto, G Casabona, A Caruso … - Journal of Neuroscience, 1997 - neuroscience.org
... The Neuroprotective Activity of Group-II Metabotropic Glutamate Receptors Requires
New Protein Synthesis and Involves a Glial-Neuronal Signaling. ...

… of apoptosis in human neutrophils requires continuous stimulation of new protein synthesis -
G Cox, RC Austin - Journal of Leukocyte Biology, 1997 - jleuk.highwire.org
... JOURNAL ARTICLE. Dexamethasone-induced suppression of apoptosis in human neutrophils
requires continuous stimulation of new protein synthesis. ...

Axonal and presynaptic protein synthesis: new insights into the biology of the neuron -
A Giuditta, BB Kaplan, J Minnen, J Alvarez, E … - Trends in Neurosciences, 2002 - Elsevier
... Ltd. All rights reserved. Opinion. Axonal and presynaptic protein synthesis:
new insights into the biology of the neuron. Antonio ...

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap … -
A Pause, GJ Belsham, AC Gingras, O Donze, TA Lin, … - Nature, 1994 - palgrave-journals.com
... The action of this new regulator of protein synthesis is therefore modulated by
insulin, which acts to stimulate the overall rate of translation and promote ...

Source: Google Scholar

New protein synthesis not essential to memory formation

Diana Yates, Life Sciences Editor
2 17-244-2177; diya@uiuc.edu

Released 7/26/07

 
CHAMPAIGN, Ill. — New research from the University of Illinois challenges the premise that the brain must build new proteins in response to an experience for that experience to be recorded in long-term memory.

The findings, published in the Proceedings of the National Academy of Sciences, could alter basic assumptions about the role of protein synthesis in memory formation.

Brain researchers have long used drugs that enhance or hinder memory formation to gain insight into the mechanisms at play. Early experiments in rats found that protein synthesis inhibitors injected into brain regions involved in memory processing could disrupt long-term memory formation. This led some to hypothesize that new protein synthesis was essential to the creation of long-term memories.
A research team led by neuroscientist Paul E. Gold discovered an alternate explanation for this effect. The researchers observed that the protein synthesis inhibitor anisomycin, which is commonly used in memory studies, causes dramatic changes in brain chemistry – apart from protein synthesis inhibition – that interfere with memory formation. They found that exposing rat brains to anisomycin sets off wild fluctuations in neurotransmitter levels in the brain region targeted in the experiment – the amygdala, one of several brain structures involved in processing memories and emotions. Large fluctuations in neurotransmitter levels in the amygdala are known to interfere with memory formation.

The researchers were surprised by the intensity of the brain’s response to anisomycin. Shortly after they injected the drug into the rat amygdala, they saw huge increases – from 1,000 to 17,000 percent – in levels of the neurotransmitters norepinephrine, dopamine and serotonin. 

“This is far above anything we’ve seen physiologically in any experiment,” Gold said. “Normally you think of a 200 percent increase as a really solid result and 300 percent as outrageously high. I wouldn’t have thought that there was that much (neurotransmitter) to be released.”

Shortly after this spike, dopamine and norepinephrine levels plummeted, dropping well below baseline for up to 48 hours after the initial exposure to anisomycin.

As expected, the rats exposed to anisomycin prior to training had impaired long-term recall of the events. To determine whether the inability to form lasting memories was caused by the anisomycin or by changes in neurotransmitter levels, the researchers repeated the experiment, adding drugs designed to counter the fluctuations in neurotransmitter levels. When the neurotransmitter imbalances were neutralized or blunted – even in the presence of anisomycin – memory formation was significantly restored.
“If we block anisomycin’s effects on the neurotransmitters, then we block many of its effects on memory,” Gold said. “We still have the protein synthesis inhibition, but it no longer causes the (same level of) amnesia.”

It is possible that some of the amnesia is due to the cessation of protein synthesis, Gold said. But, he said, the evidence suggests otherwise. “I think the protein synthesis inhibition itself is causing cells to act in unusual ways,” he said.

“No one would deny that protein synthesis is needed to maintain normal brain functions, including memory,” Gold said. “But the idea that new protein synthesis is required to make long-lasting memories should be reexamined.”

Gold is a professor of psychology and psychiatry and is affiliated with the neuroscience program and the Institute for Genomic Biology.
 
To view or subscribe to the RSS feed for Science News at Illinois, please go to: http://webtools.uiuc.edu/rssManager/608/rss.xml.
 
 
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