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Recent News and Articles on the Keywords: sleep apnea + viable treatment + nasal  Related to the article below (Last Update: 7/1/2008)

Sleep HealthCenters ? Brings Sleep Testing Home!
Business Wire (press release), CA - Jun 24, 2008
SHC has been performing home sleep testing for Obstructive Sleep Apnea (OSA) for over 10 years and are experts at diagnosing sleep disorders as well as ...
Source: Google News

Treatment of Obstructive Sleep Apnea in Pediatric Patients: Behavioral Intervention for Compliance … -
JC Rains - Clinical Pediatrics, 1995 - cpj.sagepub.com
... considered poor candidates for nasal CPAP, and historically ... that CPAP is a viable
treatment for such ... bstructive sleep apnea (OSA) involves repeated episodes of ...

… Treatment vs Continuous Positive Airway Pressure in Patients With Positional Obstructive Sleep Apnea … -
R Jokic, A Klimaszewski, M Crossley, G Sridhar, MF … - Chest, 1999 - Am Coll Chest Phys
... was felt to be a viable treatment option. ... airway pressure therapy in obstructive
sleep apnea syndrome patients: effects of chronic treatment and 1 ...

… reduction of the tongue. A porcine pilot study for the treatment of obstructive sleep apnea … -
NB Powell - Chest, 1997 - Am Coll Chest Phys
... for the treatment of obstructive sleep apnea syndrome (OSAS ... of fibrotic tissue into
surrounding viable muscle ... of hypopharyngeal obstruction during sleep and prob ...

Patient compliance with nasal CPAP therapy for sleep apnea -
MH Sanders - Chest, 1986 - Am Coll Chest Phys
... term home nasal CPAP is a viable therapy that ... ofthe utility ofnasal CPAP as a therapy
for sleep apnea. ... and indicate that, although this treatment modality is ...

Effect of Nasal Surgery on Sleep-Related Breathing Disorders. -
T Verse, JT Maurer, W Pirsig - The Laryngoscope, 2002 - laryngoscope.com
... OSA in Adults.AI = Apnea Index; AHI = Apnea Hypopnea Index ... depend on the severity
of a sleep-related breathing ... surgery is still justified as a viable option in ...

A Randomized, Controlled Study of a Mandibular Advancement Splint for Obstructive Sleep Apnea -
A MEHTA, JIN QIAN, P PETOCZ, MALI DARENDELILER, PA … - American Journal of Respiratory and Critical Care Medicine, 2001 - Am Thoracic Soc
... this form of therapy is a viable alternative to ... Our study also suggests that treatment
outcome can be ... Eves L. Reversal of obstructive sleep apnea by continuous ...

Radiofrequency Ablation for the Treatment of Mild to Moderate Obstructive Sleep Apnea. -
MB Blumen, S Dahan, B Fleury, C Hausser-Hauw, F … - The Laryngoscope, 2002 - laryngoscope.com
... as sleep deprivation or acute nasal obstruction during ... patients with severe obstructive
sleep apnea: is airway reconstructive surgery a viable treatment option ...

Bariatric surgery for treatment of sleep apnea syndrome in 15 morbidly obese patients: Long-term … -
M Scheuller, D Weider - Otolaryngology-Head and Neck Surgery, 2001 - Elsevier
... Bariatric surgery can be considered as a viable long-term treatment for severe ... nasal
continu- ous positive airway pressure (CPAP) in sleep apnea syndromes. ...

Treatment of obstructive sleep apnea in children: do we really know how? -
AJ Lipton, D Gozal - Sleep Medicine Reviews, 2003 - Elsevier
... doi:10.1053/smrv.2001.0256 CLINICAL REVIEW Treatment of obstructive sleep apnea
in children: do we really know how? Andrew J. Lipton and David Gozal ...

… -Assisted Uvulopalatoplasty for the Treatment of Mild, Moderate, and Severe Obstructive Sleep Apnea. -
RP Walker, MM Grigg-Damberger, C Gopalsami - The Laryngoscope, 1999 - laryngoscope.com
... while asleep.8 This results in sleep fragmentation, frequent ... to be effective in
suppressing apnea and thus ... LAUP appears to be a viable surgical alternative to ...

Source: Google Scholar

Nasal Cannula May Be Viable Treatment For Sufferers Of Sleep Apnea
Researchers at Johns Hopkins University have found that symptoms in patients with obstructive sleep apnea and hypopnea can be significantly reduced through treatment with nasal insufflation (TNI), using a nasal cannula to deliver warm, humidified air at a high flow rate.

"Our findings provide evidence that TNI may offer a viable treatment alternative to patients with obstructive hypopneas and apneas," said lead researcher Hartmut Schneider, M.D., of Johns Hopkins Asthma and Allergy Center.

The research was reported in the second issue for July 2007 of the American Journal of Respiratory and Critical Care Medicine published by the American Thoracic Society.
The proof of concept study included 11 patients with mild to severe apnea-hypopnea disorders, who were selected to provide a balanced range of disease severity. Apnea was defined as complete cessation of airflow for more than 10 seconds. Hypopnea was defined as a greater than 30 percent reduction of airflow.

After baseline data were established for each patient while undergoing TNI at 0, 10 and 20L/minute, subjects were randomized to receive either no treatment or treatment with TNI at 20L/minute on separate nights. Researchers then measured airflow and superglottic pressure and monitored body position, sleep arousals and respiratory events.

At TNI of 10L/minute, some indications of disordered breathing showed improvement, but airflow limitations and snoring persisted. However, at TNI of 20L/minute, all patients showed a marked improvement. "When TNI was administered, sleep and breathing patterns stabilized," said Dr. Schneider.

Furthermore, the results showed that even patients with more severe disorders gained significantly from TNI. "Although we expected marked improvements in the apnea-plus-hypopnea index (AHI) primarily in patients with hypopneas rather than obstructive apneas, TNI lowered the AHI in all subjects," the researchers wrote.

These findings suggest that TNI may be a more viable treatment option for patients with hypopnea and sleep apnea. "Current treatment options…are often intrusive or invasive and not well-tolerated, leaving a vast number of patients untreated," said Dr. Schneider. "Improved therapeutic strategies are required to treat sleep apneas and hypopneas and their associated morbidity and mortality."

Sleep apnea affects more than 12 million Americans, according to the National Institutes of Health, and is especially prevalent in overweight or obese individuals. Many more have the milder form of sleep-associated respiratory disorders, hypopnea. Untreated sleep apnea can increase the chance of having high blood pressure and risk of heart attack, stroke and diabetes, as well as putting patients at risk for work-related accidents and driving accidents.

"At present, CPAP [continuous positive airway pressure] is most effective at eliminating apneas and hypopneas, [but] long-term effectiveness is compromised by low adherence," wrote the researchers. "We developed a simplified method for increasing pharyngeal pressure by delivering warm and humidified air at a continuous high flow rate through the open nasal cannula."

While patients with severe sleep apneas may be more highly motivated to adhere to treatment with CPAP or surgery, younger, thinner and healthier patients with milder disorders may find the TNI approach appealing, according to Dr. Safwan Badr, chief of pulmonary, critical care and sleep medicine at Haper University Hospital in Detroit and chair of the American Thoracic Society's Assembly on Respiratory Neurobiology and Sleep.
The authors noted that the minimally intrusive nasal interface of TNI may improve patient adherence, and may ultimately prove more effective at managing long-term morbidity and mortality of sleep apnea." Furthermore, the fact that one flow rate and one cannula size were sufficient to stabilize breathing patterns in the majority of subjects suggests that titration of TNI may be unnecessary, streamlining the initiation of treatment.

The present study is a proof of concept, the authors wrote, and will require replication in clinical trials. However, the study represents the first step in developing a new potential alternative to current sleep apnea treatments that may lower the barrier for care in patients with sleep-associated breathing disorders.

ThIs news brief is based on an article published in the American Thoracic Society's peer-reviewed journal, the American Journal of Respiratory and Critical Care Medicine .

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society has more than 18,000 members who prevent and fight respiratory disease around the globe, through research, education, patient care and advocacy.

http://www.thoracic.org
 
 
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