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Recent News and Articles on the Keywords: stem cell + back fracture + stem  Related to the article below (Last Update: 5/5/2008)

Spinal cord injury brings family across country in search of a cure
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She subscribed to magazines like PN ? Paraplegia News ? and scoured a regular feature called "Healing Options," which reviewed stem cell therapies, ...
Source: Google News

Mesenchymal Stem Cells in Osteobiology and Applied Bone Regeneration. -
SP Bruder, N Jaiswal, NS Ricalton, JD Mosca, KH … - Clinical Orthopaedics and Related Research, 1998 - corronline.com
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back into autologous ... feasibility of using autologous stem cell implants to ...

[PDF] Tissue repair and stem cell renewal in carcinogenesis -
PA Beachy, SS Karhadkar, DM Berman? - Nature, 2004 - genomics.sbg.ac.at
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Bone Regeneration by Implantation of Purified, Culture-Expanded Human Mesenchymal Stem Cells -
SP Bruder, A Kurth - therapy - doi.wiley.com
... cylinder loaded with human mesenchymal stem cells in the ... and a mesenchymal slem
cell-loaded hydroxyapatitei-tricalcium ... in the subcutancous tissue of the back. ...

The Effect of Implants Loaded with Autologous Mesenchymal Stem Cells on the Healing of Canine … -
SP BRUDER, KH KRAUS, VM GOLDBERG, S KADIYALA - The Journal of Bone and Joint Surgery, 1998 - JBJS
... and other preclinical studies 2,5,7,8,28,40,46,50 provide the foun- dation for the
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Allogeneic Mesenchymal Stem Cells Regenerate Bone in a Critical-Sized Canine Segmental Defect -
TL Arinzeh, SJ Peter, MP Archambault, C van den … - The Journal of Bone and Joint Surgery, 2003 - JBJS
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Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon -
HA Awad, DL Butler, GP Boivin, FNL Smith, P … - Tissue Engineering, 1999 - liebertonline.com
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Future potentials for using osteogenic stem cells and biomaterials in orthopedics -
ROC Oreffo, JT Triffitt - Bone, 1999 - Elsevier
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Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection -
M Baddoo, K Hill, R Wilkinson, D Gaupp, C Hughes, … - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... Mice subjected to fracture induction were perfused with 10 ... tibias were dissected
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… 1a/CXCR4: A Mechanism for Hepatic Oval Cell Activation and Bone Marrow Stem Cell Recruitment to the … -
HM Hatch, D Zheng, ML Jorgensen, BE Petersen - Cloning & Stem Cells, 2002 - liebertonline.com
... Neural stem cells have been shown to be capable of differentiating into blood
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Human Embryonic Stem Cell Lines Derived from Single Blastomeres. -
I Klimanskaya, Y Chung, S Becker, SJ Lu, R Lanza - Obstetrical & Gynecological Survey, 2007 - obgynsurvey.com
... incidence (above 20%) of other chronic pain syndromes including headaches, irritable
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Source: Google Scholar

Back fractures common after stem cell transplant

Last Updated: 2007-07-24 16:48:27 -0400 (Reuters Health)

By Martha Kerr

NEW YORK (Reuters Health) - More than one third of children and adolescents who undergo allogenic stem cell transplantation have thinning of their bones, and one in five had crushed vertebrae in their backs, Finnish researchers report.

Allogeneic stem cell transplantation is used to treat leukemia and a variety of other cancerous and non-cancerous conditions. Allogeneic means that the cells from a closely matched donor are removed and implanted in the patient. The goal of therapy is typically to replace diseased cells of the bone marrow with fully functioning cells from another person.

Dr. Mervi Taskinen of the University of Helsinki and colleagues evaluated the bone health of 44 children a few years after they underwent stem cell transplantation. Study subjects were 18.5 years of age or younger; at the time of transplantation, they were around 10 years old.

Sixteen patients had evidence of bone thinning, the investigators report in the journal Cancer. These children were similar to the other 28 patients in terms of clinical characteristic and laboratory test results.

Bone thinning "was especially evident at the hip" in the pubertal and postpubertal children, the investigators say.

Nine patients (20 percent) had vertebral fractures and five patients (11 percent) had other fractures. Seven of the nine vertebral fractures caused no symptoms.

The investigators conclude that because of the heightened risk of bone thinning and vertebral fractures, children undergoing stem cell transplantation should be carefully monitored after the procedure and possibly given drugs that help strengthen the bones.

SOURCE: Cancer, July 15, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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