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Recent News and Articles on the Keywords: venous thromboembolism + risk assessment + risk  Related to the article below (Last Update: 5/5/2008)

Growth Differentiation Factor-15 for Prognostic Assessment of ...
RedOrbit, TX - May 2, 2008
Biomarker-based risk assessment model in acute pulmonary embolism. Eur Heart J 2005;26:2166-2172. Mareike Lankeit1, Tibor Kempf2, Claudia Dellas1, ...
New Protocol Reduces Risk for Thromboembolism
Abkhazia, CA - Apr 16, 2008
Rates of venous thromboembolism (VTE) dropped significantly at a large university medical center thanks to a new protocol that identifies high-risk patients ...
Ultrasound Not Needed if Multislice CT Used in PE Diagnosis
Medscape (subscription) - Apr 21, 2008
A history of previous thromboembolism is one of the strongest risk factors for the recurrence of thromboembolic events, and an editorial by Kyrle and ...
Newer oral contraceptives alter inflammatory status of young women
Medicexchange, UK - Apr 21, 2008
"However, evidence suggests that these preparations do not reduce, but may even increase, the risk of venous thromboembolism compared with previous ...
Laparoscopic Liver Resection
RMGH Health News, CA - Apr 9, 2008
The other indications are associated with either malignancy or risk for malignancy and/or rupture, or symptoms. Several benign lesions, such as simple ...

Insider Medicine
Ultrasound Not Necessary to Detect Pulmonary Embolism When MSCT Used
Insider Medicine, Canada - Apr 18, 2008
Use validated clinical prediction rules to estimate pretest probability of venous thromboembolism (VTE), both deep venous thrombosis (DVT) and pulmonary ...
Source: Google News

… Factors in Patients With Idiopathic Venous Thromboembolism Prevalence and Risk Assessment -
O Salomon, DM Steinberg, A Zivelin, S Gitel, R … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1999 - Am Heart Assoc
... Original Contributions. Single and Combined Prothrombotic Factors in Patients With
Idiopathic Venous Thromboembolism. Prevalence and Risk Assessment. ...

… association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk -
PY Scarabin, E Oger, G Plu-Bureau - The Lancet, 2003 - Elsevier
... Women with the diagnosis of deep venous thrombosis alone ... a senior clinician with
a special interest in thromboembolism. ... with one of these vascular risk factors. ...

Increased Risk of Venous Thrombosis in Oral-Contraceptive Users Who Are Carriers of Factor V Leiden … -
JP Vandenbroucke, T Koster, E Briet, PH Reitsma, … - Obstetrical & Gynecological Survey, 1995 - obgynsurvey.com
... Single and Combined Prothrombotic Factors in Patients With Idiopathic Venous
Thromboembolism: Prevalence and Risk Assessment. Arteriosclerosis ...

Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness Analysis … -
R Alikhan, AT Cohen, S Combe, MM Samama, L … - Archives of Internal Medicine, 2004 - Am Med Assoc
... medical patients with clinical risk factors for venous thromboembolism, particularly
those ... will facilitate the formulation of a risk assessment model based on ...

Risk Factors for Venous Thromboembolism -
FA Anderson Jr, FA Spencer - Circulation - Am Heart Assoc
... to individualized risk assessment. References. Anderson, Jr. FA, Wheeler HB. Physician
practices in the management of venous thromboembolism: a community-wide ...

… of Hyperhomocyst (e) inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism -
PM Ridker, CH Hennekens, J Selhub, JP Miletich, MR … - Circulation, 1997 - Am Heart Assoc
... A quantitative assessment of plasma homocysteine as ... Hyperhomocysteinemia as a risk
factor for deep ... B, Hultberg B. Plasma homocysteine in venous thromboembolism. ...

… factors for venous thromboembolism: a preliminary study for the development of a risk assessment … -
MM Samama, OE Dahl, DJ Quinlan, P Mismetti, N … - Haematologica, 2003 - haematologica.org
... 2003, Ferrata Storti Foundation Quantification of risk factors for venous
thromboembolism: a preliminary study for the development of a risk assessment tool ...

First-time use of newer oral contraceptives and the risk of venous thromboembolism -
S Suissa, L Blais, WO Spitzer, J Cusson, M Lewis, … - Contraception, 1997 - Elsevier
... Figure 2. Adjusted rate ratio of venous thromboembolism as a function of ... to confounding
by indication, is common in the nonexperimental risk assessment of drugs ...

… Replacement Therapy and the Risk of Hospitalization for Venous Thromboembolism: A Population-based … -
C Varas-Lorenzo, LA Garc?a-Rodr?uez, C Cattaruzzi … - American Journal of Epidemiology, 1998 - Oxford Univ Press
... exclusion criteria, and 145 did not have a confirmed episode of venous thromboembolism. ...
Exposure and other risk factors assessment Hormone replacement ...

[CITATION] Assessment of the Risk for Venous Thromboembolism Among Users of Hormone Replacement Therapy. -
E Oger, PY Scarabin - Drugs & Aging, 1999
... Fig. 1. Assessment of the risk for venous thromboembolism associated with hormone
replacement therapy: adjusted risk ratios and their 95% confidence interval. ...

Source: Google Scholar

Risk Assessment For Venous Thromboembolism Among Hospitalized Patients
Venous thrombosis (VTE), the formation of blood clots in a vein, is a major health problem for hospitalized patients in the United States. In the short term, VTE can lead to deep vein thrombosis (DVT), typically in the legs, and pulmonary embolism (PE), which occurs when a piece of the blood clot migrates into an artery of the lungs. Evidence implicates PE in up to 10 percent of sudden in-hospital deaths. In the long term, VTE can lead to post-thrombotic syndrome (PTS), marked by persistent leg pain, swelling, and cramps, or pulmonary hypertension. Fortunately, such dire complications are easy to avoid through preventive strategies, from compression boots to anti-clotting medications. Unfortunately, inpatients at risk for VTE are routinely overlooked.
To provide a clear, quantitative sense of the scope of this problem, researchers at the University of Massachusetts Medical School and Mayo Clinic College of Medicine set out to estimate the total number of US inpatients at risk for VTE -- a crucial figure previously unknown. Their results, which will be published online in the American Journal of Hematology (http://www.interscience.wiley.com/journal/ajh), strongly support the need for reinforcing established national guidelines for identifying patients at risk for VTE, as well as monitoring compliance with hospital protocols for VTE prevention.

"Our findings suggest that each year, almost one-third of hospitalized patients are at risk of VTE," notes the study's lead author, Dr. Frederick Anderson. "This highlights the magnitude of the US public health risk posed by this potentially preventable condition."

To determine the number of hospitalized patients at 'substantial risk' for developing VTE, Dr. Anderson and his colleagues used criteria defined by the American College of Chest Physicians (ACCP) -- widely respected guidelines that have been available to physicians across the country for 15 years. They applied them to the Nationwide Inpatient Sample (NIS), the largest all-payer inpatient care database in the US, containing information on over 8 million hospital stays, for 2003. That year, an estimated 38,220,659 patients were discharged from roughly 6,000 acute-care hospitals. 56 percent of these patients (21, 574, 294 individuals) met the study's inclusion criteria for age and length of hospital stay: two days or more, sufficient time to diagnose and prescribe VTE prevention. Of the study population, 20 percent (7,786,390 individuals) were surgical patients ages 18 and older, and 40 percent (15,161,586 individuals) were patients ages 40 and older hospitalized for a serious medical condition.

When the ACCP criteria for VTE risk were applied to the surgical patients, 44 percent were considered low risk and would not have been candidates for preventative measures.
However, 15 percent were at moderate risk, 24 percent were at high risk, and 17 percent were at extreme risk of VTE, due to a combination of age, other medical conditions, type of surgery, and prior history of blood clots. In the group hospitalized for reasons other than surgery, 51 percent met the ACCP criteria for VTE risk based on the nature of their illness: heart failure, respiratory failure, pneumonia, cancer, acute myocardial infarction, stroke, trauma, and sepsis among them.

In total, more than 12 million of the approximately 38 million patients discharged from US hospitals in 2003 were at risk of VTE during their hospital stay based on the standard ACCP criteria. From their data, the researchers were unable to gauge what proportion of this staggering number of at-risk patients benefited from therapeutic intervention. Yet, based on numerous reports, Dr. Anderson and his associates speculate that at least half of hospitalized patients at risk for VTE receive no preventative care, and countless suffer the consequence of serious complications, including premature death.

Samuel Z. Goldhaber, MD, Professor of Medicine at Harvard and a cardiovascular specialist with Brigham and Women's Hospital, notes this study's significant contribution toward raising VTE awareness and improving intervention for hospitalized patients. Still, improving inpatient care is only the first step. "VTE risk does not simply evaporate when patients are discharged from hospitals," Dr. Goldhaber drives home, stressing the need to keep outpatients informed of VTE risk, and committed to exercising regularly and following their doctor's prescriptions for preventive measures. "Anderson and his group have defined a broad 'base of the iceberg' of danger," he observes. "However, the fundamental problem is even more profound and goes beyond the millions of hospitalized patients annually that they have identified."

Article: "Estimated Annual Numbers of US Acute-care Hospital Patients at Risk for Venous Thromboembolism," Frederick Anderson, Max Zayaruzny, John Heit, Dogan Fidan, and Alexander Cohen; American Journal of Hematology, July 2007; (DOI: 10.1002/ajh.20983).

Editorial: "Venous Thromboembolism Risk Among Hospitalized Patients: Magnitude of the Risk Is Staggering," Samuel Z. Goldhaber, MD; American Journal of Hematology, July 2007; (DOI: 10.1002/ajh.20997).

Source: Amy Molnar
John Wiley & Sons, Inc.
 
 
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