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Recent News and Articles on the Keywords: new model + autism risk + autism  Related to the article below (Last Update: 5/12/2008)

Epic Genetics: Genes? chemical clothes may underlie the biology ...
Science News - May 9, 2008
Genes alone can only explain a few of the reasons people contract mental illnesses, become addicts or have developmental disorders, such as autism. ...
New Evidence Links Mercury Emissions to Rates of Autism
Natural News.com, AZ - Apr 29, 2008
The study, Proximity to point sources of environmental mercury release as a predictor of autism prevalence appears in the journal Health & Place (2008). ...
Legwork for new school starts
Greensboro News Record, NC - May 9, 2008
Bobadilla replied: "(Construction management) at risk is just another tool in our tool box." * Approved a model for Northeast Guilford High School to ...
School ban for kids with no MMR jab
Sunday Mirror, UK - May 11, 2008
Concern that MMR was linked to autism was first raised by Dr Andrew Wakefield in 1998. It caused vaccination levels to drop sharply in the late 1990s and ...
Talladega: Clint Bowyer NASCAR Sprint Cup Race Preview
PaddockTalk - Apr 22, 2008
Chevy Antes up for Autism ? Autism Speaks and Chevrolet recently announced a month-long promotion to help generate up to $1 million for the non-profit ...
Thimerosal Vaccines and Mercury Blood Levels
AAP Grand Rounds (subscription), IL - May 1, 2008
While there is mounting evidence that there is no association between infant immunization and autism or thimerosal-containing vaccines and autism, ...
Subsidized. Affordable. Beautiful?
The Santa Barbara Independent, CA - May 3, 2008
The nun simply smiled modestly and kept walking through the new model community that she?s helped build. ?We want to have our own little village,? she said ...
Honouring Outstanding Educators
Canada NewsWire (press release), Canada - Apr 14, 2008
They established an Autism Awareness Week at the school to foster understanding and fundraise for Autism Ontario's "Together for Autism" campaign. ...
Stimulant Therapy and Risk for Subsequent Substance Use Disorders ...
Am J Psychiatry (subscription) - May 1, 2008
We also excluded potential subjects if they had major sensorimotor disabilities (paralysis, deafness, blindness), psychosis, autism, inadequate command of ...
Autism myth lives on
USA Today - Apr 15, 2008
By Sam Wang As the brother of an autistic person and a brain scientist, I have been hoping that the increased focus on autism in the news would lead to a ...
Source: Google News

Genetics of Autism: Overview and New Directions -
P Szatmari, MB Jones, L Zwaigenbaum, JE MacLean - Journal of Autism and Developmental Disorders, 1998 - Springer
... et al., 1989 Bailey et al., 1995- New sample ... developing nervous system to lead to
autism (it may ... This model predicts that obstetric complications may be less ...

The UCLA-University of Utah Epidemiologic Survey of Autism: Recurrence Risk Estimates and Genetic … -
ER Ritvo, LB Jorde, A Mason-Brothers, BJ Freeman, … - Annual Progress in Child Psychiatry and Child Development, …, 1990 - books.google.com
... Cohen DJ: Neurobiologic aspects of autism (editorial). N Engl J Med 1 988: 31 8:
1 390-1 392 2. Ritvo ER, Freeman BJ: A medical model ofautism: etiology ... New York ...

… complex phenotypes with selection and measurement error: a twin and family history study of autism. -
A Pickles, P Bolton, H Macdonald, A Bailey, A Le … - American Journal of Human Genetics, 1995 - pubmedcentral.nih.gov
... Using data from a recent family history study of autism, and a similar study of ... New
findings are presented supporting a multiple-locus model of inheritance ...

Mapping autism risk loci using genetic linkage and chromosomal rearrangements -
N Conferences, D Discovery - Nature Genetics, 2007 - nature.com
... 67 Autism Speaks, 2 Park Avenue, New York, New York 10016, USA. 68 These authors
contributed equally to this work. ... In our model for autism, combinations of ...

Prenatal and perinatal risk factors for autism -
L Burd, R Severud, J Kerbeshian, MG Klug - Journal of Perinatal Medicine, 1999 - Walter de Gruyter
... The new birth certificate data may also be used to de- velop national files of linked
birth and death certificates [25]. ... Burd et al, Autism risk factors ... model. ...

[BOOK] Mindblindness: An Essay on Autism and Theory of Mind -
S Baron-Cohen - 1995 - books.google.com
... As the capstone of this research pro- gram, he and his colleagues used these new
cognitive models to develop a method for detecting autism far earlier than ...

Perinatal Risk Factors for Infantile Autism. -
CM Hultman, P Spar?n, S Cnattingius - Epidemiology, 2002 - epidem.com
... 1973-1987, 186 cases in the adjusted model with full ... New York: American Elsevier,
1975 ... infantile autism; perinatal; risk factors; maternal; intrauterine growth. ...

No evidence for links between autism, MMR and measles virus. -
W CHEN, S LANDAU, P SHAM, E FOMBONNE - Psychological Medicine, 2004 - pt.wkhealth.com
... the risk of later developing AD, a new model containing an ... the model fit of these
two models to test ... could affect a child's risk of later developing autism. ...

Evidence for a Susceptibility Gene for Autism on Chromosome 2 and for Genetic Heterogeneity -
JD Buxbaum, JM Silverman, CJ Smith, M Kilifarski, … - The American Journal of Human Genetics, 2001 - Elsevier
... Center, Mount Sinai School of Medicine, New York 5 ... involved parametric analyses under
two models as well ... have been considered in the autism research community ...

Autism as a strongly genetic disorder: evidence from a British twin study. -
A Bailey, A Le Couteur, I Gottesman, P Bolton, E … - Psychological Medicine, 1995 - pt.wkhealth.com
... difficulties were identified in the new non-autistic ... Furthermore, the relative risk
for autism in either ... than expected under any Mendelian model, but similar ...

Source: Google Scholar

New Model for Autism Suggests Women Carry the Disorder and Explains Age as a Risk Factor

A new model for understanding how autism is acquired has been developed by a team of researchers led by Cold Spring Harbor Laboratory (CSHL) and Albert Einstein College of Medicine. Autism is a developmental disorder, characterized by language impairments, social deficits, and repetitive behaviors. The researchers analyzed data on autism incidence and found a previously unrecognized pattern. The pattern can be explained by assuming that spontaneous germ-line mutation is a significant cause of the disorder. Parents, especially women, who acquire the mutation – but do not exhibit severe symptoms of the disorder – have a 50% chance of passing the mutation on to their children. Sons often show the most severe symptoms.
Spontaneous mutations are changes in a chromosome that alter genes. Germ-line mutations are newly acquired in a germ cell of a parent, and sometimes are transmitted to offspring at conception. Men and women are equally as likely to acquire a spontaneous mutation that can cause autism, but autism is three times more likely in men, making women the more likely carriers of new mutations. “The fact that germ-line mutations increase with age places older parents at a higher risk of having children with autism, explaining a pattern that has been recently observed,” said CSHL co-author of the study Michael Wigler, Ph.D.  
 
The model proposes two prominent risk classes for families affected by autism. Low risk families give rise to sporadic autism, the more common form, by spontaneous germ-line mutation. The children, mostly female, who receive such a mutation, but do not display the disorder, are the source of the high risk families. The data show that the transmission pattern to boys in high risk families is often of a dominant pattern that may account for a quarter of autism. Although the data does not answer whether there is a gradation of lower risk, the model builds on recent CSHL findings that spontaneous mutation is frequent in sporadic autism and less frequent in children from high risk families.
 
Wigler suggests that “what we now know about spontaneous mutations and autism offers an alternative to traditional thinking about genetic disorders as purely heritable from a parent. This has implications for other disorders such as morbid obesity, schizophrenia, and congenital heart disease.”
 
The full citation of the paper published in the July 31, 2007 print edition of the Proceedings of the National Academy of Sciences is: "A unified theory for sporadic and inherited autism," by Xiaoyue Zhao, Anthony Leotta, Vlad Kustanovich, Clara Lajonchere, Daniel H. Geschwind, Kiely Law, Paul Law, Shanping Qiu, Catherine Lord, Jonathan Sebat, Kenny Ye and Michael Wigler.

The research was funded by the Simons Foundation and utilized databases from the Autistic Resource Exchange (AGRE) Consortium, the University of Michigan, and the Interactive Autism Network (IAN). IAN is an on-line national autism registry and database launched in April by the Kennedy Krieger Institute. Families impacted by an Autism Spectrum Disorder can contact IAN at www.ianproject.org.

CSHL is a private, non-profit research and education institution dedicated to exploring molecular biology and genetics in order to advance the understanding and ability to diagnose and treat cancers, neurological diseases, and other causes of human suffering.

For more information, visit www.cshl.edu.
 
 
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