Even so, "this provides encouragement to patients with metastatic breast cancer" who were the focus of the study, said lead author Dr. Stephen Chia, a medical oncologist at the British Columbia Cancer Agency. "We can tell them that we have more drugs available, and it appears they do allow them to live longer."
Breast cancer is the most commonly diagnosed type of cancer, and only lung cancer kills more women.
Researchers have had a difficult time figuring out whether newer drugs, including the class called aromatase inhibitors, are effective for the most serious forms of breast cancer. It's considered unethical to assign one group of terminal cancer patients to a drug and give others a placebo or simply keep them comfortable.
"We're making a leap of faith as to what we're doing, how we're spending our resources, that we're actually allowing them to live longer," Chia said.
The new study looked at patients in the Canadian province of British Columbia between 1991 and 2001. All the 2,150 women had metastatic breast cancer, meaning tumors had spread beyond the breast.
The researchers found that the average survival time in the 1991-1992 and 1994-1995 periods was fairly stable, at 438 and 450 days, respectively. But when new drugs became available in the middle of the decade, survival grew to 564 days (1997-1998) and 667 days (1999-2001).
The newer medications included chemotherapy drugs and drugs known as aromatase inhibitors that tinker with estrogen levels. The study doesn't prove conclusively that the drugs lead to higher life spans, but the authors wrote that it seems likely.
An increase in life span of about eight months may not seem like much. But Chia pointed out that it's an average, and some women live longer.
In addition, he said, the newer drugs appear to be easier on patients, so they have better quality of life during their final days.
The results are in the Sept. 1 issue of the journal Cancer. |