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Recent News and Articles on the Keywords: researchers show + suicide path + set  Related to the article below (Last Update: 5/12/2008)

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Source: Google News

Apoptosis: Forging a Path to Cell Death -
M Barinaga - Science, 1996 - sciencemag.org
... in response to TNF, says apoptosis researcher David Vaux ... MacKenzie's team went on
to show that the ... Despite that uncertainty, some researchers suspect that the ...

ICE-like proteases in apoptosis -
S Kumar - Trends in Biochemical Sciences, 1995 - Elsevier
... the Hanson Centre for Cancer Research, Box 14 ... cells constitutively express- ing Nedd2s
show no protection ... assump- tion that all cell-death path- ways converge ...

Sex differences in the causes of adolescent suicide ideation -
RL Simons, PI Murphy - Journal of Youth and Adolescence, 1985 - Springer
... an instrument designed by the Behavioral Research and Evaluation ... the zero-order
correlations between suicide ideation and ... Figures 1 and 2 show the results of ...

Research on unemployment and suicide -
AJ Kposowa - British Medical Journal, 2003 - jech.bmj.com
... Research on unemployment and suicide ... the risk of melanoma or death in plane crashes,
explains why these two causes of death often show a strong positive ...

Catostrophizing and Untimely Death -
C Peterson, MEP Seligman, KH Yurko, LR Martin, HS … - Psychological Science, 1998 - Blackwell Synergy
... global explanations for bad events show emotional, motivational ... A single researcher
read through all responses in ... r = .52), as previous research has typically ...

Do They Suffer More? Reflections on Research Comparing Suicide Survivors to Other Survivors -
S Ellenbogen, F Gratton - Suicide and Life-Threatening Behavior, 2001 - Guilford Publications
... no empirical evidence that suicide survivors show a greater ... this essay opens new
path- ways for grief research. ... on whether a given mode of death pro- vokes a ...

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N Danigelis, W Pope - Soc. F., 1978 - HeinOnline
... Consequently, the researcher who distinguishes between egoism and ... Only further research
can determine whether Durkheim's ... the data in Suicide show a strong ...

Predisposing and Precipitating Factors for Suicide Among Alcoholics: Empirical Review and Conceptual … -
KR Conner, PR Duberstein - Alcoholism: Clinical and Experimental Research, 2004 - alcoholism-cer.com
... some studies have failed to show alcohol abuse ... distinction has been demonstrated
in research on aggression ... in turn increases the likelihood of suicide (path 2 ...

The use of structural equation modeling in generative research: Toward the design of a preventive … -
SG West, I Sandler, DR Pillow, L Baca, JC Gersten - American Journal of Community Psychology, 1991 - Springer
... The researcher is thus forced to provide a clear and unambiguous ... Modeling in Generative
Research ... In addition, the results show that the relationship between pa ...

Studying interpersonal factors in suicide: Perspectives from depression research
J Davila, SE Daley - Suicide Science: Expanding the Boundaries. Boston: Kluwer …, 2000 - Springer
... interpersonal factors in suicide: approaches to ... many interpersonal variables show
similar associations with depression, research on interpersonal ...

Source: Google Scholar

Stressed Cells Set On Suicide Path By Bak Protein, Researchers Show
When a cell is seriously stressed, say by a heart attack, stroke or cancer, a protein called Bak just may set it up for suicide, researchers have found.

In a deadly double whammy, Bak helps chop the finger-like filament shape of the cell's powerhouse, or mitochondrion, into vulnerable little spheres. Another protein Bax then pokes countless holes in those spheres, spilling their pro-death contents into the cell.

"We found out Bak has a distinct function in regulation of the mitochondrial morphology," says Dr. Zheng Dong, cell biologist at the Medical College of Georgia and the Veterans Affairs Medical Center in Augusta and corresponding author on a paper published this week in Proceedings of the National Academy of Sciences. "Bax, on the other hand, is not involved in morphological regulation but needs to be there to puncture holes."
"One has to break up, kind of soften, the mitochondria for injury, and the other one actually punches the holes to kill it," says Craig Brooks, MCG graduate student and the paper's first author.

Bak and Bax have similar structures and scientists have long suspected they play major, similar roles in programmed cell death, or apoptosis. "These two proteins are very important for mitochondrial injury and subsequent apoptosis," says Dr. Dong.

To stress cells, they blocked oxygen supplies and used the common chemotherapeutic agent cisplatin, then documented that filamentous mitochondria became fragmented very early and quickly in apoptosis. Ironically they also found the deadly fragmentation results from Bak's interaction with mitochondria-shaping proteins called mitofusins, which help mitochondria keep their filamentous shape in non-stressed cells. Dr. Dong suspects Bak may also play a role in mitofusin regulation in normal, non-stressful conditions.

In fact, the researchers suspect Bak, Bax and the contents they spill into the cell all have roles in keeping a cell functioning until a stressor kicks in.

"They probably are both kept in check normally in the cell by other proteins, and when something happens that overwhelms the cell, it activates Bak and Bax to start cell death," says Mr. Brooks. "Some of the same proteins, cytochrome c is the big one, are needed for daily mitochondrial function like making energy, but if they are released from the mitochondria, they activate a cell killing or apoptotic pathway," says Dr. Dhong, referencing the contents that spill from punctured mitochondria.

Looking at kidney cells and neurons in a Bak deficient mouse, they also showed that Bak and Bax need each other to successfully spawn cell suicide. "If you have Bak but not Bax, the mitochondria still fragment but they don't die; if you have Bax but not Bak, you still have punctures in the mitochondria but with low efficiency," says Mr. Brooks.

Now they want to know exactly how Bak interacts with mitofusins, how the interaction is regulated and how it affects mitochondrial morphology, physiology and pathology. Their long-term goal for better understanding the cell suicide mechanism is developing drugs to block it in the case of a stroke, for example, or induce it to kill cancer.

Dr. Dong recently received a $1.1 million, four-year renewal grant from the National Institute of Diabetes & Digestive & Kidney Diseases to further study the structural changes of mitochondria during apoptosis and normal physiological conditions.

Source: Toni Baker
Medical College of Georgia
 
 
 
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