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Recent News and Articles on the Keywords: more common + severe among + colitis  Related to the article below (Last Update: 5/12/2008)

Vital: Read Your Body Signs
Glasgow Daily Record, UK - May 11, 2008
These are classic signs of hypothyroidism, a fairly common but often under diagnosed condition especially among women. Hair texture change can signal iodine ...
Salix Pharmaceuticals Reports 1Q2008 Results
Business Wire (press release), CA - May 6, 2008
MOVIPREP should also be used with caution in patients with severe ulcerative colitis, ileus, gastrointestinal obstruction or perforation, gastric retention, ...SLXP
Interim Results from Boceprevir Phase II Study in Genotype 1 ...
FOXBusiness - Apr 27, 2008
Safety data from the study showed that the most common adverse events reported in the boceprevir arms were fatigue, anemia, nausea and headache. ...
Three Studies Presented at 43rd EASL Showed Higher SVR for PEGASYS ... PR-CANADA.net (press release)
Final Results of Ideal Study Presented at Annual Meeting of the ... FOXBusiness
all 45 news articles »  SGP - SGP-B
Electroconvulsive Therapy for Severe Major Depressive Disorder ...
Psychosomatics (subscription) - Apr 30, 2008
... Affairs Medical Center Durham, NC TO THE EDITOR: Depression is one of the more common neuropsychiatric presentations after liver transplantation. ...
A Bad Germ Gets Worse
NBC 11.com, CA - May 2, 2008
Consequences can range from severe diarrhea to colitis and toxic megacolon, a condition that can lead to shock and death. Warren, now 39, may have gotten ...
Abbott Announces HUMIRA? (adalimumab) Approved In Japan For The ...
Medical News Today (press release), UK - Apr 21, 2008
Clinical trials are underway evaluating the potential of HUMIRA in ulcerative colitis. To date, HUMIRA has been approved in 75 countries and more than ...ABT
Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the ...
CNNMoney.com (press release) - Apr 16, 2008
Clinical trials are underway evaluating the potential of HUMIRA in ulcerative colitis. To date, HUMIRA has been approved in 75 countries and more than ...ABT
UCB Launches CIMplicity(TM) Program to Enhance Treatment Support ...
PR Newswire (press release), NY - Apr 24, 2008
In controlled Crohn's clinical trials, the most common adverse events that occurred in more than or equal to 5% of Cimzia(R) patients (n=620) and more ...EBR:UCB
Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data ...
PR Newswire (press release), NY - Apr 17, 2008
Final results will be presented for the EPIC3 study, in which more than 2000 hepatitis C patients with moderate to severe fibrosis or cirrhosis who failed ...SGP - SGP-B
Source: Google News

Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently … -
C Flobert, C Cellier, A Berger, A Ngo, E … - American Journal of Gastroenterology, 2000 - Blackwell Synergy
... Among the 21 patients operated on, the time elapsed between the onset of symptoms
and the surgical procedure was ... Severe colitis was more common in patients ...

[PDF] Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage -
DM Jensen, GA Machicado, R Jutabha, TO Kovacs - N Engl J Med, 2000 - usagiedu.com
... patients with diverticulosis and severe hematochezia (21 ... Among the 24 patients in
the second ... steroidal antiinflammatory drugs was more common among patients in ...
-

Further evidence for an association between psoriasis, Crohn's disease and ulcerative colitis -
V M. YATES, G WATKINSON, A KELMAN - British Journal of Dermatology, 1982 - Blackwell Synergy
... has been shown to be slightly more common in females ... Three patients had very extensive
and severe Crohn's disease ... the only two examples found among the total ...

Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease -
GF Bonner, M Walczak, L Kitchen, M Bayona - American Journal of Gastroenterology, 2000 - Blackwell Synergy
... Active disease included mild, moderate, or severe disease, as well as ... For ulcerative
colitis, NSAID use was only slightly more common among patients with ...

Olsalazine in the Treatment of Ulcerative Colitis among Patients Intolerant of Sulphasalazine: A … -
S Meyers, DB Sachar, DH Present, HD Janowitz - Scandinavian Journal of Gastroenterology, 1988 - informaworld.com
... in 36 patients, moderate in 24, and severe in 6 ... Among the patients receiving active
drug, 15 were treated ... More women were treated, particularly in the 0.75 g ...

Ulcerative Colitis in Greece: Clinicoepidemiological Data, Course, and Prognostic Factors in 413 … -
JK Triantafillidis, A Emmanouilidis, ON Manousos, … - Journal of Clinical Gastroenterology, 1998 - jcge.com
... more extensive the involvement, the more severe was the ... available data.16,17 Ulcerative
colitis is more ... in rural areas and also more common among persons of ...

Ischemic colitis: Patterns and prognosis -
WE Longo, GH Ballantyne, RJ Gusberg - Diseases of the Colon & Rectum, 1992 - Springer
... form of this disease and fortunately is not common. ... 15 It is more likely to occur
following surgery ... Nilsson R. Clinical appear- ance in severe ischemic colitis ...

Spondyloarthropathies in sub-Saharan Africa. -
M Mijiyawa, O Oniankitan, MA Khan - Current Opinion in Rheumatology, 2000 - co-rheumatology.com
... predominant lower limb involvement is far more often observed ... involvement is rare,
and the disease is often severe. ... HLA allele B35 (which is common in Africans ...

One-stage restorative proctocolectomy without temporary ileostomy for ulcerative colitis -
MER Williamson, WG Lewis, PM Sagar, PJ Holdsworth, … - Diseases of the Colon & Rectum, 1997 - Springer
... threatening compli- cations were much more common, however, among ... postoperative
complications were much more severe and posed ... We have per- formed more than 300 ...

PLANTAR FASCIITIS AND ACHILLES TENDINITIS AMONG 150 CASES OF SERONEGATIVE SPONDARTHRITIS -
JC GERSTER - Rheumatology, 1980 - Br Soc Rheumatology
... Among a total of 150 cases of seronegative spondarthritis ... cluded in the seronegative
spondarthritis group; however severe talalgia is more common in RS ...

Source: Google Scholar

Certain Type Of Colitis Appears To Have Become More Common And More Severe Among Hospitalized Patients
The rate of cases of colitis (colon inflammation) caused by the bacteria Clostridium difficile more than doubled among patients hospitalized in the United States between 1993 and 2003, and the illness was more severe and associated with an increased mortality rate, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.

C. difficile inhabits the intestines of approximately 1 percent to 3 percent of healthy adults and about 20 percent of patients receiving antibiotics, according to background information in the article. When the balance of bacteria in the colon is altered, C. difficile can cause a variety of symptoms, including severe or complicated diarrhea that may eventually lead to death. Treatment for life-threatening forms of the disease usually involves colectomy, or removal of all or part of the colon, which is associated with a high rate of complications and high mortality.
"Three million new cases of C. difficile colitis occur in the United States each year: as many as 10 percent of patients hospitalized for at least two days are affected," the authors write. "Anecdotal evidence and some case series suggest that C. difficile colitis has become more common and potentially more pathogenic."

Rocco Ricciardi, M.D., M.P.H., then of the University of Minnesota Medical School, Minneapolis, and now of Lahey Clinic, Burlington. Mass., and colleagues analyzed discharge data from a database of U.S. hospitals between 1993 and 2003. The database, the Nationwide Inpatient Sample, "includes data from about 7 million hospital stays per year in 1,000 hospitals located in 35 states; thus, it approximates a 20 percent stratified sample of U.S. community hospitals," the authors write. "It provides information on patient demographics, socioeconomic factors, admission profiles, hospital profiles, state codes, discharge diagnoses, procedure codes, total charges and vital status at hospital discharge."

In the 78,091,119 discharges that occurred in the 11-year study period, 299,453 patients had a diagnosis of C. difficile colitis, a rate of 383 cases per 100,000 discharged patients. "The rate of C. difficile colitis discharges increased from 261 cases per 100,000 discharged patients in 1993 to 546 cases per 100,000 discharged patients in 2003, a 109 percent increase," the authors write. Colectomy rate, which was 2.7 per 1,000 patients overall, increased from 1.2 per 1,000 patients in 1993 to 3.4 per 1,000 patients in 2003. The total rate of death among patients with C. difficile colitis was 33.6 deaths per 100,000 discharged patients throughout the study; this rate increased 147 percent in 11 years, from 20.3 deaths per 100,000 discharged patients in 1993 to 50.2 deaths per 100,000 discharged patients in 2003.

"Hospital discharge with a C. difficile diagnosis was significantly more likely with increasing calendar year," the authors continue. "In addition, the likelihood of death and of treatment with colectomy also significantly increased over time."
The results document the changing nature of C. difficile colitis but do not offer explanations for the change, the authors note. The shift could be caused by new strains of the bacteria, its increasing resistance to antibiotics or the increasing severity of illness and therefore susceptibility to infection among hospitalized patients in the United States.

"Heightened awareness of the increasing disease burden of C. difficile colitis is an important first step in controlling the public health ramifications of this important and morbid nosocomial [hospital-acquired] infection," they conclude.

Arch Surg. 2007;142(7):624-631
http://www.archsurg.ama-assn.org
 
 
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