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Recent News and Articles on the Keywords: could lead + first drug + mit  Related to the article below (Last Update: 5/12/2008)

Deadly Dose: Rensselaer Heparin Expert Helps Uncover Source of ...
Rensselaer Polytechnic Institute, NY - Apr 25, 2008
Linhardt is helping lead the global race to develop a synthetic alternative to heparin that could help eliminate the potential for contamination and adverse ...
Sports Watch
WBOC TV 16, MD - May 2, 2008
He helped lead the Rockies to their first World Series appearance last fall. NASHVILLE, Tenn. (AP) - There's a new twist to Adam "Pacman" Jones' legal ...
Three Luminaries, Two Third Revolutions, and One Nice Suit: An ...
Xconomy, MA - May 2, 2008
It happened while Bob was in the middle of his (probably unnecessary) introductions of the three luminaries who had joined us Tuesday evening to lead a ...
Country Reports on Terrorism 2007: Europe and Eurasia Overview - III
Journal of Turkish Weekly, Turkey - May 8, 2008
In October, terrorist suspects Tariq Mousa al Ghazi and Luis Felipe Moreno were handed over to the Drug Enforcement Administration by Romanian authorities. ...
Penn State's Frightening Defense
Foreign Policy In Focus - Apr 25, 2008
Fentanyl could fall under this category, as it is a Schedule 2 drug and can be obtained for personal use via prescription. ...
Stripped-down investigation leads nowhere
Today's Zaman, Turkey - Apr 19, 2008
It was the first clear evidence that revealed what Turks call the "deep state," a network of clandestine connections between criminal gangs that have ...
What is bad for Wall Street and the US elites is good for both
Brazzil.com, CA - Apr 18, 2008
A quote from Dan Brown's book Drug War by Major General Smedley D. Butler in 1935 states why (pg.223): "I spent 33 years and 4 months in active service as a ...
MOVIE REVIEWS NEW RELEASES
Nashua Telegraph, NH - Apr 16, 2008
PG-13: Crude sexual references throughout, strong bullying, language, drug references and partial nudity. LEATHERHEADS In 1925, Dodge Connolly is a charming ...
Movie capsules AZ, April 18
phillyBurbs.com, PA - Apr 18, 2008
Trouble follows when they discover photos that could embarrass the royal family, and the situation turns ugly when they find themselves in possession of a ...
Bush to Nasrallah: An Offer Hezbollah cannot refuse?
Atlantic Free Press, Netherlands - Apr 25, 2008
Within hours, US inspired charges were leveled by Bulgaria that Hezbollah has benefited from drug smuggling revenue across from its territories. ...
Source: Google News

Nanoparticulate systems for brain delivery of drugs -
J Kreuter - Advanced Drug Delivery Reviews, 2001 - Elsevier
... The first in vitro experiments employed poly(methyl-[2 ... fluidization and an enhanced
drug permeability through ... 3. The nanoparticles could lead to an opening of ...

The Evolution of Integrative Capability: Innovation in Cardiovascular Drug Discovery* -
R HENDERSON - Industrial and Corporate Change, 1994 - Oxford Univ Press
... and the belief that better science could lead to improved ... The first beta-blocker
was discovered by Sir James ... class and refused to approve further drugs in the ...

Underutilization of antihypertensive drugs and associated hospitalization -
RF Maronde, LS Chan, FJ Larsen, LR Strandberg, MF … - Med Care, 1989 - JSTOR
... pressure measurements at the time of first hospitalization were ... 12) 34 (7) 0.045a
Lack-of-drug ratio mean ... allow for an analytic approach that could lead to the ...

Patient Safety in Guideline-Based Decision Support for Hypertension Management: ATHENA DSS -
MK Goldstein, BB Hoffman, RW Coleman, SW Tu, RD … - Journal of the American Medical Informatics Association, 2002 - Am Med Inform Assoc
... messages about minor problems, and could lead to data ... diuretics were among the first
drugs available for ... of this drug class, we could inadvertently contribute ...

Topical Drug Treatment in Acne -
H Gollnick, M Schramm, HPM Gollnick - Logo, 1998 - content.karger.com
... for example encapsulations in liposomes, could lead to higher ... no efficacy of
spironolactone could be demonstrated ... Terris BZ, Jick H: First trimester topical ...

Research and Development Costs and Returns: The US Pharmaceutical Industry -
MN Baily - Journal of Political Economy, 1972 - JSTOR
... submitted to the applied econometrics course at MIT in the ... equation or a mistake
in specification could lead to a ... in year T from a new drug first introduced in ...

… to reduce HIV infection have not been successful to reduce the prevalence of HCV in intravenous drug … -
I Hernandez-Aguado, JM Ramos-Rincon, MJ Avi?o, J … - European Journal of Epidemiology, 2001 - Springer
... to assume that these preventive measures could lead to a ... that alleged changes in
risk behaviours could have on ... Year of first visit 1990 166 74.1 66.6?80.6 1 ...

SCREENING OF TOXIC COMPOUNDS IN MAMMALIAN CELL CULTURES -
B Ekwall - Annals of the New York Academy of Sciences, 1983 - Blackwell Synergy
... lethal and/or therapeutic dosage in man could be shown to ... The first type of validation
study compared results from ... the toxicity in virro of 27 drugs to several ...

The use of the MTT assay to study drug resistance in fresh tumour samples -
JM Sargent - Chemosensitivity Testing in Oncology, 2002 - books.google.com
... these same protection mechanisms that must first be overcome ... Assay to Study Drug
Resistance in Fresh Tumour Samples ... the use of these techniques could lead to a ...

Differential Pricing for Pharmaceuticals: Reconciling Access, R&D and Patents -
PM Danzon, A Towse - International Journal of Health Care Finance and Economics, 2003 - Springer
... adoption of patents in DCs will lead to higher ... DC markets, for which differential
pricing could simultaneously yield ... First, R&D is a fixed, globally joint cost ...

Source: Google Scholar

MIT Indentifies Mechanism Behind Fear - Work Could Lead To First Drug For Post-Traumatic Stress Disorder
Researchers from MIT's Picower Institute for Learning and Memory have uncovered a molecular mechanism that governs the formation of fears stemming from traumatic events. The work could lead to the first drug to treat the millions of adults who suffer each year from persistent, debilitating fears - including hundreds of soldiers returning from conflict in Iraq and Afghanistan.

The team will report their results in the July 15 advance online publication of Nature Neuroscience.

A study conducted by the Army in 2004 found that one in eight soldiers returning from Iraq reported symptoms of post-traumatic stress disorder (PTSD). According to the National Center for PTSD in the United States, around eight percent of the population will have PTSD symptoms at some point in their lives. Some 5.2 million adults have PTSD during a given year, the center reports.
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear learned in a particular context. Conversely, the learned fear persisted when the kinase's activity was increased in the hippocampus, the brain's center for storing memories.

Cdk5, paired with the protein p35, helps new brain cells, or neurons, form and migrate to their correct positions during early brain development. In the current work, the MIT researchers looked at how Cdk5 affects the ability to form and eliminate fear-related memories.

"Remarkably, inhibiting Cdk5 facilitated extinction of learned fear in mice. This data points to a promising therapeutic avenue to treat emotional disorders and raises hope for patients suffering from post-traumatic stress disorder or phobia," Tsai said.

Emotional disorders such as post-traumatic stress and panic attacks stem from the inability of the brain to stop experiencing the fear associated with a specific incident or series of incidents. For some people, upsetting memories of traumatic events do not go away on their own, or may even get worse over time, severely affecting their lives.

Treating these disorders involves methods geared toward making the behavior go away, or become extinct, but the molecular mechanisms underlying the extinction process are not well understood. However, Tsai said, studies have shown that some of the molecular machinery that initially encodes the troubling memories also regulates their extinction.

In the current work, genetically engineered mice received mild foot shocks in a certain environment and were re-exposed to the same environment without the foot shock. Mice with increased levels of Cdk5 activity had more trouble letting go--or extinguishing--the memory of the foot shock and continued to freeze in fear. Conversely, in mice whose Cdk5 activity was inhibited, the bad memory of the shocks disappeared when the mice learned that they no longer needed to fear the environment where the foot shocks had once occurred.


"In our study, we employ mice to show that extinction of learned fear depends on counteracting components of a molecular pathway involving the protein kinase Cdk5," said Tsai, a Howard Hughes Medical Institute investigator. "We found that Cdk5 activity prevents extinction, at least in part by negatively affecting the activity of another key kinase.

In addition to Tsai, authors include MIT affiliate Farahnaz Sananbenesi; Picower Institute research affiliates Andre Fischer and Xinyu Wang; Christina Schrick and Jelena Radulovic of Northwestern University; and Rachel Neve of McLean Hospital in Belmont, Mass.

This work was supported by the National Institutes of Health and the National Institute of Mental Health.

http://www.mit.edu
 
 
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