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Recent News and Articles on the Keywords: microvascular invasion + prognostic significance + tumor  Related to the article below (Last Update: 5/5/2008)

[PDF] Significance of angiogenesis and microvascular invasion in renal cell carcinoma -
Y Dekel, R Koren, V Kugel, PM Livne, R Gal - Pathol Oncol Res, 2002 - webio.hu
... 23. Samma S, Yoshida K, Ozono S, et al: Tumor thrombus and ... M, Kirkali Z, Yorukoglu
K, et al: Prognostic significance of microvascular invasion in localized ...
-

LOW CLINICAL STAGE RENAL CELL CARCINOMA: RELEVANCE OF MICROVASCULAR TUMOR INVASION AS A PROGNOSTIC … -
PD GON?ALVES, M SROUGI, MF DALL?OGLIO, KRM LEITE, … - The Journal of Urology, 2004 - Elsevier
... recurrence during followup but microvascular invasion and lymph ... metastasis were the
only prognostic parameters with independent statistical significance. ...

Prognostic significance of muc1 epithelial mucin expression in breast cancer -
MA McGuckin, MD Walsh, BG Hohn, BG Ward, RG Wright - Human Pathology, 1995 - Elsevier
... brane staining showed no prognostic significance (Figs 11 ... and the presence of
microvascular invasion and carcinoma ... with metastatic carci- noma, tumor size and ...

Prognostic significance of microvascular invasion in localized renal cell carcinoma. -
M Sevinc, Z Kirkali, K Yorukoglu, U Mungan, M Sade - Eur Urol, 2000 - ncbi.nlm.nih.gov
... The aim of this study is to study the prognostic significance of microvascular invasion
(MVI) in ... MVI was related to the grade of the tumor and tumor size (p ...

Microscopic Vascular Invasion is the Most Relevant Prognosticator After Radical Nephrectomy for … -
H Van Poppel, H Vandendriessche, K Boel, V Mertens … - The Journal of Urology, 1997 - Elsevier
... Y. Hirao and E. Okajima, Tumor thrombus and microvascular invasion as prognostic
factor ... LC Lasky and C. Limas, Prognostic significance of morphologic ...

Microvascular Invasion in Prostate Cancer: Prognostic Significance in Patients Treated by Radical … -
U Int - Logo, 1998 - content.karger.com
... Microvascular Invasion in Prostate Cancer ... defined as the presence of tumor within
endothelial ... Prognostic Significance of VI The simplicity of the definition and ...

Intratumor microvessel density as a prognostic factor in cancer. -
N Weidner - The American Journal of Pathology, 1995 - pubmedcentral.nih.gov
... cells secreted by microvascular endothelial cells ... Tumor invasion and metastases:
biochemical mechanisms. ... The prognostic significance of tumor vascularity in ...

A POSTOPERATIVE PROGNOSTIC NOMOGRAM PREDICTING RECURRENCE FOR PATIENTS WITH CONVENTIONAL CLEAR CELL … -
M SORBELLINI, MW KATTAN, ME SNYDER, V REUTER, R … - The Journal of Urology, 2005 - Elsevier
... 11 which are of known prognostic significance for CCRCC ... of the most important prognostic
factors for ... presence of necrosis, microvascular invasion and clinical ...

Serum Vascular Endothelial Growth Factor Predicts Venous Invasion in Hepatocellular Carcinoma: A … -
RTP Poon, IOL Ng, B Cecilia Lau, LX Zhu, WC Yu, CM … - Annals of Surgery, 2001 - annalsofsurgery.com
... 36-38 Microvascular invasion cannot be used as a selection ... for the prediction of
vascular invasion and hematogenous ... may be useful as a new prognostic factor in ...

Tumor Thrombus and Microvascular Invasion as Prognostic Factors in Renal Cell Carcinoma -
S Samma, K Yoshida, S Ozono, S Ohara, Y Hayashi, S … - Japanese Journal of Clinical Oncology, 1991 - FPCR
... significance of two types of vascular invasion (macroscopic tumor thrombus into
the renal vein or vena cava inferior and microvascular invasion) as prognostic ...

Source: Google Scholar

Microvascular Tumor Invasion: Prognostic Significance In Low-Stage Renal Cell Carcinoma
UroToday.com- The importance of microvascular invasion (MVI) of renal cell carcinoma (RCC) as a prognostic factor has been much debated in the literature of urology. Opinions range from no significance to the most significant histologic variable that can be reported. Here, Madbouly and colleagues report their outcomes for patients with RCC examining MVI as a prognostic variable.

The authors report on 8 patients with localized RCC with at least one year of follow-up who underwent radical nephrectomy over a 14 year period. Of these, 6 developed metastatic disease in follow-up and ultimately died of RCC. Eight patients were noted to have MVI of these, 50% developed metastatic disease whereas only 5% of patients without MVI developed metastatic disease. The presence of MVI was associated with male sex (p=0.017) and increased stage (p=0.039). The 5 year disease free survival was only 45% for those with MVI versus 90% for those without. In their multivariate analysis that included stage, grade, histology, tumor size, age, the presence of perinephric fat invasion, and MVI only MVI was a significant predictor of disease free survival (p=0.007).

The authors conclude that MVI is a significant predictor of patient outcome that should be reported on all patients undergoing surgery for RCC.

The small numbers of the study and the fact that patient sex was also significant in predicting outcome make these conclusions somewhat suspect but the findings regarding MVI concur with many other larger studies in the literature.

Madbouly K, Al-Qahtani SM, Ghazwani Y, Al-Shaibani S, Mansi MK

Urology. 69(4):670-74, April 2007
doi:10.1016/j.urology.2007.01.012

Reported by UroToday.com Contributing Editor Christopher G. Wood, MD

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.

To access the latest urology news releases from UroToday, go to: www.urotoday.com
 
 
 
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