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Recent News and Articles on the Keywords: prostate cancer + cancer markers + cancer  Related to the article below (Last Update: 5/12/2008)

Study Shows Prostate Cancer Gene 3 (PCA3) Correlates With Severity ...
Canada NewsWire (press release), Canada - May 8, 2008
(2006) Molecular markers of prostate cancer. Urol Oncol. 24, 538-551 4 Loeb,S. et al. (2006) Pathological characteristics of prostate cancer detected ...GPRO

Gather.com
Gene combination raises prostate cancer risk
Gather.com, MA - May 6, 2008
Men with four of the five genetic variants were more than four times as likely to develop prostate cancer than those with none of the markers. ...
New questions raised about NL prostate cancer testing
CBC.ca, Canada - Apr 16, 2008
The Newfoundland and Labrador government has been asking questions about tests used to determine prostate cancer treatment, in light of pathology lab ...
Protein That Helps Predict Prostate Cancer Survival Identified
Science Daily (press release) - Apr 22, 2008
Inflammatory cells are attracted to cancer sites and this local inflammation can lead to a release of inflammatory markers, like CRP. ...
Have another cup of tea
Health24.com, South Africa -
An extract of catechins obtained from green tea reduced the incidence of prostate cancer in a group of Italian men by 26,7% compared to men receiving ...

TopCancerNews.com
Prostate Cancer Spread Predicted by New Blood Marker
TopCancerNews.com, TX - May 3, 2008
Researchers report finding a new blood biomarker that enables close to 98 percent accuracy in predicting the spread of prostate cancer to regional lymph ...

Business Wire (press release)
North Shore Radiation Therapy Offers Prostate Cancer Patients The ...
Business Wire (press release), CA - Apr 17, 2008
There are several techniques used to achieve image guided radiation therapy for prostate cancer. For some tumors, gold markers can be placed in the tumor. ...
Eating less fat may prevent prostate cancer, study shows
Media Newswire (press release), NY - Apr 21, 2008
"We're looking at specific markers and growth factors in human tissue known to be important for development and progression of prostate cancer," he said. ...
Plant power
Malaysia Star, Malaysia - Apr 26, 2008
As consumption of tomato products increased, levels of lycopene in the blood increased, and the risk for prostate cancer decreased. Breast cancer is the ...
Identification Of Prostate Cancer Susceptibility Loci
Medical News Today (press release), UK - Apr 20, 2008
UroToday.com - Dr. Kiermeney (Nijmegen) presented data on susceptibility loci in prostate cancer (CaP). Searching for genes in this setting can be done by ...
Source: Google News

… , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer -
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI … - Science, 1997 - sciencemag.org
... Glioblastoma line A172 has a deletion encompassing markers JL25 through KP8 and ... The
prostate cancer cell lines with homozygous deletions are NCI H660 and PC-3 ...

Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk -
JL Stanford - Cancer Research, 1997 - AACR
... Cancer Research. ARTICLES. Polymorphic repeats in the androgen receptor gene:
molecular markers of prostate cancer risk. JL Stanford ...

… of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer -
JB Welsh, LM Sapinoso, AI Su, SG Kern, J Wang- … - Cancer Research, 2001 - AACR
... Research Advances in Brief. Analysis of Gene Expression Identifies Candidate
Markers and Pharmacological Targets in Prostate Cancer. John ...

Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer -
RE Reiter, Z Gu, T Watabe, G Thomas, K Szigeti, E … - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
... Home page JV Tricoli, M. Schoenfeldt, and BA Conley Detection of Prostate Cancer
and Predicting Progression: Current and Future Diagnostic Markers Clin. ...

The polycomb group protein EZH2 is involved in progression of prostate cancer. -
S Varambally, SM Dhanasekaran, M Zhou, TR Barrette … - Nature, 2002 - ncbi.nlm.nih.gov
... Thus, dysregulated expression of EZH2 may be involved in the progression of prostate
cancer, as well as being a marker that distinguishes indolent prostate ...

… (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer … -
MF Darson, A Pacelli, P Roche, HG Rittenhouse, RL … - Urology, 1997 - ncbi.nlm.nih.gov
1997 Jun;49(6):857-62. Human glandular kallikrein 2 (hK2) expression in prostatic
intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker. ...

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search -
JR Smith? - Science, 1996 - sciencemag.org
... Table 2. Linkage results for susceptibility to prostate cancer and nine
markers on chromosome 1 in 91 families. and represent the ...

a-Methylacyl-CoA Racemase A New Molecular Marker for Prostate Cancer 1 -
J Luo, S Zha, WR Gage, TA Dunn, JL Hicks, CJ … - Cancer Research, 2002 - AACR
... comparing the mRNA expression profile of cancerous lesions with noncancerous lesions,
multiple candidates of molecular markers for prostate cancer have emerged ...

Prevalence of Prostate Cancer among Men with a Prostate-Specific Antigen Level<= 4.0 ng per … -
IM Thompson, DK Pauler, PJ Goodman, CM Tangen, MS … - The New England Journal of Medicine, 2004 - nejm.org
... JR. Evaluation of prostate-specific antigen and prostatic acid phosphatase
as prostate cancer markers. Urology 1986;28:472-479. ...

Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate -
TA Stamey, N Yang, AR Hay, JE McNeal, FS Freiha, E … - N Engl J Med, 1987 - Mass Med Soc
... used in the diagnosis and follow-up of patients with prostate cancer. Stamey and
colleagues evaluated the usefulness of a new marker, prostate-specific antigen ...

Source: Google Scholar

EPCA-2: A Highly Specific Serum Marker For Prostate Cancer
UroToday.com- The steady decrease in prostate cancer mortality is indirect evidence that prostate cancer early detection using serum PSA and the digital rectal examination saves lives. Nevertheless, the use of serum PSA for prostate cancer screening remains controversial due to its low specificity. Developing additional serum tumor markers for early detection would prove invaluable for improving early detection while reducing the number of unnecessary biopsies.

In the April issue of Urology, Leman and colleagues describe the performance characteristics of EPCA-2, a novel nuclear protein marker for prostate cancer cells. EPCA and EPCA-2 were identified at Johns Hopkins using proteomic technology to analyze the subcellular protein composition of prostate cancer cell nuclei.
Banked serum from several subsets of patients was used including: 63 men with a serum PSA less than 2.5 ng/ml and a normal DRE (30 of those had undergone a negative 12-core biopsy), 80 men with prostate cancer (40 organ-confined and 40 non-organ confined), 35 men with symptomatic BPH, and men with prostate cancer and PSA levels less than 2.5 ng/ml and (5) 134 controls.

In men without cancer, the EPCA-2.22 ELISA assay had 92% specificity (95% CI, 85% to 96%) and 94% sensitivity (95% CI, 93% to 99%) for prostate cancer using a threshold value of 30 ng/mL. In men with a diagnosis of prostate cancer, EPCA was found to have a sensitivity of 90% and 98% in men with organ confined and non-organ confined disease, respectively. Interestingly, the EPCA-2.22 serum assay was effective in differentiating patients with localized disease versus extraprostatic extension with an area under the curve of 0.89 (p < 0.0001).

This exciting study suggests that the EPCA-2 protein serum assay exhibits favorable performance characteristics which are potentially superior to serum PSA. Whether this test will retain its sensitivity and specificity when used in a screening population remains to be studied.

Leman ES, Cannon GW, Trock BJ, Sokoll LJ, Chan DW, Mangold L, Partin AW, Getzenberg RH

Urology. 69(4):714-20, April 2007
doi:10.1016/j.urology.2007.01.097

Reported by UroToday.com Contributing Editor Ricardo F. Sánchez-Ortiz, MD

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.

To access the latest urology news releases from UroToday, go to: www.urotoday.com
 
 
 
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