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Recent News and Articles on the Keywords: systems pathology + prostate cancer + prostate  Related to the article below (Last Update: 5/12/2008)

Cerner Millennium Health Information Technology Implemented
Al-Bawaba, Jordan - May 11, 2008
The center will treat the most common types of cancer, as well as those prevalent in the Middle East, such as lung, prostate and breast cancer. ...CERN
Immunotherapy: Enlisting The Immune System To Fight Cancer
Science Daily (press release) - Apr 17, 2008
Blocking CTLA-4, a cellular molecule on lymphocytes that inhibits immune response, produced meaningful clinical benefits in patients with prostate cancer ...
Vice President of Aureon Laboratories to Present at GTCbio's 2nd ...
PR-Inside.com (Pressemitteilung), Austria - Apr 22, 2008
Aureon have applied this platform to the development and validation of two commercially available tests for men with prostate cancer: 1) Prostate Px? ...
Burnham Institute for Medical Research Advances Biomarker Research ...
Earthtimes, UK - Apr 22, 2008
In one project alone, 240 prostate cancer cases displayed on 1600 tissue microarray cores were reviewed by four pathologists from different academic ...
Learn about the Cancer Diagnostic Testing World Markets
Trading Markets (press release), CA -
Diagnostic Methods for Cancer Detection 4.1 Organ Specific Tumor Markers 4.1.1 Colon Cancer 4.1.2 Prostate Cancer 4.1.3 Pancreatic Cancer 4.1.4 Breast ...

Virginia Business Magazine
Va. Institutions taking leadership roles in treatment and research
Virginia Business Magazine, VA - May 1, 2008
There have been big gains ? cases of prostate cancer, for example, dropped nearly 6 percent between 2000 and 2004, and breast cancer declined 3 percent ...
Avoiding Unnecessary Surgery: Part Three
Evening Bulletin, PA - Apr 25, 2008
For example, urologists are likely to recommend surgery for prostate cancer. Radiologists and radiation oncologists are most likely to recommend radiation. ...
IRIS International Presents Study Results of Its Investigational ...
PR-Inside.com (Pressemitteilung), Austria - Apr 18, 2008
The results of the retrospective study showed that the Ultrasensitive NADiA total PSA (tPSA) Assay reliably predicts prostate cancer bio chemical recurrence ...IRIS
MB Alerts: IRIS International Inc. Review in Progress
Trading Markets (press release), CA - Apr 21, 2008
The results of the retrospective study showed that the Ultrasensitive NADiA total PSA (tPSA) Assay reliably predicts prostate cancer bio chemical recurrence ...IRIS

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Postoperative Nomogram for Disease Recurrence After Radical Prostatectomy for Prostate Cancer -
MW Kattan, TM Wheeler, PT Scardino - Journal of Clinical Oncology, 1999 - jcojournal.org
... Improved prediction of prostate cancer recurrence through systems pathology J. Clin.
Invest., July 2, 2007; 117(7): 1876 - 1883. [Abstract] [Full Text] [PDF], ...

Neuro-endocrine cells--a new prognostic parameter in prostate cancer. -
RJ Cohen, G Glezerson, Z Haffejee - Br J Urol, 1991 - ncbi.nlm.nih.gov
... cells--a new prognostic parameter in prostate cancer. ... Z. Department of Anatomical
Pathology, University of ... than do conventional histological grading systems. ...

Hormone Therapy Failure in Human Prostate Cancer: Analysis by Complementary DNA and Tissue … -
L Bubendorf, M Kolmer, J Kononen, P Koivisto, S … - jnci, 1999 - jnci.oxfordjournals.org
... the introduction of human prostate tissue or ... discovered from experimental model systems
of cancer ... traditional methods in molecular pathology, substantial work ...

Serum Proteomic Patterns for Detection of Prostate Cancer -
EF Petricoin, DK Ornstein, CP Paweletz, A Ardekani … - jnci, 2002 - jnci.oxfordjournals.org
... BA Hitt, PJ Levine, Correlogic Systems, Inc., Bethesda ... Program, Laboratory of Pathology,
CCR, NCI ... a histopathologic diagnosis of prostate cancer (serum prostate ...

… -matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men 1 -
BL Adam, Y Qu, JW Davis, MD Ward, MA Clements, LH … - Cancer Research, 2002 - AACR
... Reading of Tea Leaves or an Insight to Clinical Systems Biology? ... A Murphy, C Martin,
O Sheils, and JO'Leary Molecular pathology of prostate cancer J. Clin. ...

a-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer -
MA Rubin, M Zhou, SM Dhanasekaran, S Varambally, … - JAMA, 2002 - Am Med Assoc
... Detailed prostatectomy pathology reports included the presence or ... were graded using
the Gleason grading system. ... atrophy, high-grade PIN, and prostate cancer. ...

Gleason Score 2-4 Adenocarcinoma of the Prostate on Needle Biopsy: A Diagnosis That Should Not Be … -
JI Epstein - The American Journal of Surgical Pathology, 2000 - ajsp.com
... of the Gleason grading system among 10 prostate pathology experts. 2 There were
four cases considered to represent Gleason score 2-4 cancer by the two authors ...

Biological Determinants of Cancer Progression in Men With Prostate Cancer -
TA Stamey, JE McNeal, CM Yemoto, BM Sigal, IM … - JAMA, 1999 - Am Med Assoc
... move away from the scoring system and simply ... In: Tannenbaum M, ed. Urologic Pathology:
The Prostate. ... Multiple cancers in the prostate: morphologic features of ...

Clinical Validation of Candidate Genes Associated with Prostate Cancer Progression in the CWR22 … -
S Mousses, L Bubendorf, U Wagner, G Hostetter, J … - Cancer Research, 2002 - AACR
... PK]; and Department of Pathology, National Cancer ... explore molecular mechanisms of
prostate cancer progression, we ... analysis of the CWR22 xenograft model system. ...

… and Images for Pathology Studies Focusing on Clinical Outcome The Prostate Specialized Program of … -
S Manley, NR Mucci, AM De Marzo, MA Rubin - American Journal of Pathology, 2001 - ASIP
... biomarkers including E-cadherin, prostate-specific antigen ... This system facilitates
the statistical analysis of ... data with clinical and pathology information in ...

Source: Google Scholar

Improved Prediction Of Prostate Cancer Recurrence Through Systems Pathology
UroToday.com- Dr. Cordon-Cardo and collaborators report development of systems pathology that incorporates clinical and pathologic variables to predict prostate cancer (CaP) recurrence. Their work appears in the online version of the Journal of Clinical Investigation.

Systems pathology is a methodology that uses object-oriented image analysis, pattern recognition, and quantitative biomarker multiplexing that are analyzed by supervised machine learning algorithms. An initial study based upon 323 patients identified that high levels of androgen receptor as identified by immunohistochemical staining were correlated with a reduced time to PSA recurrence.
This was then combined with the pathologic variables of biopsy Gleason score, seminal vesicle invasion, extracapsular extension, primary radical prostatectomy Gleason score, and preoperative PSA in addition to the texture of epithelial nuclei and cytoplasm in tumor areas for the systems pathology platform.

A validation study was performed in 366 patients but only 61 of these had adequate tissue in the microarrays to be included. PSA recurrence was found in 26 of the 61 men (43%). The model applied to these 61 patients demonstrated a sensitivity of 96% and a specificity of 72% for the detection of PSA recurrence by 5 years post surgery.

The authors comment that this approach provides an aspect of personalized medicine to help decision-making.

Cordon-Cardo C, Kotsianti A, Verbel DA, Teverovskiy M, Capodieci P, Hamann S, Jeffers Y, Clayton M, Elkhettabi F, Khan FM, Sapir M, Bayer-Zubek V, Vengrenyuk Y, Fogarsi S, Saidi O, Reuter VE, Scher HI, Kattan MW, jr. Bianco FJ, Wheeler TM, Ayala GE, Scardino PT, Donovan MJ

J Clin Invest. ePub, June 7, 2007
Doi: 10.1172/JCI31399

Reported by UroToday.com Contributing Editor Christopher P. Evans, M.D

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.
 
 
 
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