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Recent News and Articles on the Keywords: stem cells + human embryonic + discovery  Related to the article below (Last Update: 5/5/2008)

UW stem-cell pioneer one of TIME 100
Daily Cardinal, WI -
Each discovered a way to genetically reprogram human skin cells to act like embryonic stem cells. TIME?s entry called the discovery an achievement with ?a ...
UW's Thomson one of Time's 'World's Most Influential People' The Capital Times
all 2 news articles »

The Future of Things
Artificial Stem Cells May Cure Parkinson?s Disease
The Future of Things -
... from human skin cells. The artificial stem cells have the same characteristics as embryonic stem cells and can thus create almost any cell in the body. ...
Scientists Derive Cardiac Stem Cell; Study May Strengthen VistaGen ...
Cell Based Assay News (subscription), NY - May 2, 2008
CDI would test those compounds using human cardiomyocytes derived from human embryonic stem cells. Kolaja added that ?it is also interesting that the ...
Mouse Adult Stem Cells Developed into Heart and Blood Cells
Earthtimes (press release), UK - Apr 30, 2008
Although iPS cells are believed to be equivalent to embryonic stem cells, rigorous scientific studies are needed to confirm their potential to differentiate ...
Researchers Grow Heart and Blood Cells from Reprogrammed Skin Cells
Newswise (press release) - Apr 30, 2008
?I believe iPS cells address many of the shortcomings of human embryonic stem cells and are the future of regenerative medicine,? said MacLellan, ...
Stem cell treatments safer alternative to joint replacement
Monterey County Herald, CA - May 3, 2008
"Treatments and research in this country have been hindered by ethical concerns that were related to the use of embryonic stem cells, which, as it turns out ...
StemCells, Inc. Granted Key US Patent Covering Composition of ...
FOXBusiness - Apr 23, 2008
StemCells has pioneered the discovery and development of HuCNS-SC(R) cells, its highly purified, expandable population of human neural stem cells. ...STEM
Heart Cells Made From Embryonic Stem Cells
Medical News Today, UK - Apr 24, 2008
Keller and colleagues followed the development of heart cells in human embryonic stem cells while they differentiated in cultures in the lab. ...
Embryonic stem cell debate trips up Ohio cloning bill
Akron Beacon Journal, OH - Apr 24, 2008
Stem cells also come from amniotic fluid and other sources, which aren't controversial because they don't involve the destruction of human embryos, ...
Heart Progenitor Cells Developed from Embryonic Stem Cells; New ...
Canada NewsWire (press release), Canada - Apr 23, 2008
Entitled, "Human cardiovascular progenitor cells develop from a KDR1 embryonic-stem-cell-derived population," the study will also appear in the print ...
Source: Google News

Embryonic Stem Cell Lines Derived from Human Blastocysts -
JA Thomson, J Itskovitz-Eldor, SS Shapiro, MA … - Science, 1998 - sciencemag.org
... and express cell surface markers that characterize primate embryonic stem cells
but do ... These cell lines should be useful in human developmental biology ...

Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro -
BE Reubinoff, MF Pera, CY Fong, A Trounson, A … - Nature Biotechnology, 2000 - nature.com
... Embryonic stem cells provide a model to study early human embryology, an
investigational tool for discovery of novel growth factors and medicines, and a ...

In vitro differentiation of transplantable neural precursors from human embryonic stem cells -
SC Zhang, M Wernig, ID Duncan, O Br?stle, JA … - Nature Biotechnology, 2001 - nature.com
... In vitro differentiation of transplantable neural precursors from human embryonic
stem cells. ... Embryonic stem cell lines derived from human blastocysts. ...

Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential … -
M Amit, MK Carpenter, MS Inokuma, CP Chiu, CP … - Developmental Biology, 2000 - Elsevier
... derived from preimplantation embryos (embryonic stem cell lines, ES ... Human ES cell
lines have widespread implications for human developmental biology ...

Neural progenitors from human embryonic stem cells -
BE Reubinoff, P Itsykson, T Turetsky, MF Pera, E … - Nature Biotechnology, 2001 - nature.com
... derivation of neural progenitor cells from human embryonic stem (ES) cells ... The potential
use of human ES cells as ... When ES cells are induced to differentiate in ...

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells -
JS Draper, K Smith, P Gokhale, HD Moore, E Maltby, … - Nature Biotechnology, 2003 - nature.com
... 2003; | doi:10.1038/nbt922 Recurrent gain of chromosomes 17q and 12 in cultured
human embryonic stem cells. Jonathan S Draper 1, 6 ...

Human embryonic stem cells -
MF Pera - Journal of Cell Science, 2000 - jcs.biologists.org
... of candidate human pluripotent embryonic stem (ES) and ... applications envisioned for
human cells with these ... territories of human embryonic gene expression for ...

Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells -
C Xu, S Police, N Rao, MK Carpenter - Circulation Research, 2002 - Am Heart Assoc
... to enhance cardiac function in preclinical animal models and for utility in drug
discovery. ... Feeder-free growth of undifferentiated human embryonic stem cells. ...

Specification of motoneurons from human embryonic stem cells -
XJ Li, ZW Du, ED Zarnowska, M Pankratz, LO Hansen, … - Nature Biotechnology, 2005 - nature.com
... Nature Biotechnology 23, 215 - 221 (2005) Published online: 30 January 2005; |
doi:10.1038/nbt1063 Specification of motoneurons from human embryonic stem cells. ...

Electromechanical integration of cardiomyocytes derived from human embryonic stem cells -
I Kehat, L Khimovich, O Caspi, A Gepstein, R … - Nature Biotechnology, 2004 - nature.com
... 2004; | doi:10.1038/nbt1014 Electromechanical integration of cardiomyocytes
derived from human embryonic stem cells. Izhak Kehat 1, 3 ...

Source: Google Scholar

Discovery May Change The Future Of Human Embryonic Stem Cells Research
A startling discovery on the development of human embryonic stem cells by scientists at McMaster University will change how future research in the area is done.

An article published in the prestigious scientific journal Nature this week reports on a new understanding of the growth of human stem cells. It had been thought previously that stem cells are directly influenced by cells in the local environment or 'niche', but the situation may be more complex. Human embryonic stem cells are perpetual machines that generate fuel for life.
In this week's Nature, researchers of the McMaster Cancer and Stem Cell Research Institute show that human embryonic stem (ES) cells can actually produce distinctive niche cells, which then release stem-cell nourishing proteins to help keep their 'parents' ticking over.

Scientific Director Mick Bhatia and colleagues provide the first evidence that human ES cells have the unique ability to generate human-ES-cell-derived fibroblast-like niche cells (hdFs) in vitro despite removal from their in vivo microenvironment. These hdFs then provide a continuous source of supportive proteins, including insulin-like growth factor 2 (IGF-II), which they now show could be 'the' protein to sustain hESCs..

Researchers are interested in the relationship between stem cells and their niche, because the niche represents a route for modifying stem cell behaviour -- if human ES cells can be reliably guided down a particular pathway, then they can be more readily used for future clinical therapy to regenerate damaged tissue such as neurons for Parkinson's disease, or insulin producing cells for diabetes .

The research has been funded by the Canadian Institutes for Health Research and the National Cancer Institute of Canada.

The Nature article is the latest in a series of important papers published by scientists at the 18-month-old institute, which was established with funding by philanthropist Michael G. DeGroote. The institute has a research focus on the molecular determinants of cancer and tissue repair and is building scientific momentum.
"This discovery of a new fundamental understanding about how human stem cells develop is the kind of scientific work which has already put this Institute on the map as the leader in this field," said John Kelton, dean and vice-president of McMaster's Faculty of Health Sciences.

Mick Bhatia said that he and his scientific team have been working for the past year to prove themselves wrong, but as every test confirmed their discovery, it was time to submit the work for international peer review from other experts.

"This will be critical for future developments involving drug and gene screening of human ES cells, that will be required before clinical use of human stem cells of this kind," he said.

The paper was published electronically on Nature's website and will be published in print later this month.

McMaster University, a world-renowned, research-intensive university, fosters a culture of innovation, and a commitment to discovery and learning in teaching, research and scholarship. Based in Hamilton, the University, one of only four Canadian universities to be listed on the Top 100 universities in the world, has a student population of more than 23,000, and an alumni population of more than 125,000 in 125 countries.

Note: available for downloading at http://www.fhs.mcmaster.ca/media.htm

* Colour pictures of human stem cells

* Short video of human stem cell development

* Graphic of how human stem cell develops niche cells which provide nourishment to stem cell

* Pictures of scientists of McMaster Stem Cell and Cancer Research Institute

Source: Veronica McGuire
McMaster University
 
 
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