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Recent News and Articles on the Keywords: may lead + better drugs + research  Related to the article below (Last Update: 5/5/2008)

Scientists unveil enzyme that may be malaria?s Achilles heel
Thaindian.com, Thailand -
The research team points out that several existing malaria drugs by stopping haems transformation. According to the researchers, their study may help ...
Science Documentaries for Youngsters
Slashdot - May 4, 2008
I'd like to find some documentary videos geared to this age level that may explain better these concepts and theories. I've found a few PBS specials online ...
Albany Molecular Research Inc. Q1 2008 Earnings Call Transcript
Seeking Alpha, NY -
In addition, we affirmed our forecasts in orders up to three additional late stage developmental APIs that we are making for three new innovative drugs, ...AMRI
Rethinking race and inequality.
Slate -
Everything about it hurt: the research, the writing, the reactions, the regrets. Not a day has gone by that I haven't thought about it. ...
Compound That Could Lead To New Blood Pressure Drugs Discovered
Science Daily (press release) - May 1, 2008
The findings, which appear in the May 1 edition of the American Heart Association journal Hypertension, could lead to a new class of antihypertensive drugs ...
Kidney Disease Substantially Worsens in a Fourth of African ...
National Institutes of Health (press release) -
The condition can lead to kidney failure, premature death, heart attacks, strokes, bone disease, and growth and developmental problems in children. ...
Sticking with treatment
Gather.com, MA - 50 minutes ago
Or your doctor may recommend combining the drug with another one, switching to a different drug, or replacing drugs with therapy or other forms of treatment ...
Purdue-developed genomics tool could lead to better medicine
PressZoom (press release), Netherlands - Apr 28, 2008
If we have data based on genetic information, however, that company may be able to make multiple drugs, and nearly all of the affected population would be ...
Undernews For May 3, 2008
Scoop.co.nz, New Zealand -
Research suggests that more than 40 percent of freshmen at four-year institutions do not graduate in six years. Colleges trumpet the statistic that, ...

Charlotte Weekly
Union County Primary 2008
Charlotte Weekly, NC -
A lot of folks aren?t aware that we have serious problems with drugs and crime in Union County. As growth increases, so does crime. ...
Source: Google News

Chromatin?IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors -
EA Leadbetter, IR Rifkin, AM Hohlbaum, BC … - Nature, 2002 - nature.com
... the identification of signalling components and/or inhibitors specific for this
pathway may eventually lead to the ... Antisense Nucleic Acid Drug Dev. ...

Adherence in AIDS clinical trials: A framework for clinical research and clinical care -
JR Ickovics, AW Meisler - Journal of Clinical Epidemiology, 1997 - Elsevier
... they feel that they are not getting better or they are indeed getting sicker, drug
effectiveness may ... under- estimate of the treatment effect may lead to a ...

Experimental and computational approaches to estimate solubility and permeability in drug discovery … -
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney - Advanced Drug Delivery Reviews, 2001 - Elsevier
... of the chemists perception of lead attractiveness is ... at one research location, but
may be familiar ... in a calculated range associated with better solubility or ...

The Value of Improving the Productivity of the Drug Development Process: Faster Times and Better … -
JA DiMasi - PharmacoEconomics, 2002 - pharmacoeconomics.adisonline.com
... process holds the promise of better decision making ... of substantial efficiencies in
new drug discovery and ... and other new discovery technologies may lead in the ...

A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis -
K Andries, P Verhasselt, J Guillemont, HWH … - Science, 2005 - sciencemag.org
... the activity of R207910 was significantly better than at ... Inhibition of ATP synthase
function may lead to ATP ... resistance with existing anti-TB drugs, and our ...

… and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs -
CJ Foster, DM Prosser, JM Agans, Y Zhai, MD Smith, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig
... of the target receptor of the thienopyridine drugs affords us a better understanding
of platelet function and provides tools that may lead to the ...

DRUG COMPLIANCE IN PEDIATRICS Clinical and Research Issues -
DM Matsui - The Pediatric Clinics of North America, 1997 - Elsevier
... Cues and reminders may be useful tools to improve ... New technology should lead to the
development of ... The trend toward better compliance with medication at night ...

[PDF] Audio-computer interviewing to measure risk behaviour for HIV among injecting drug users: a quasi- … -
DC Des Jarlais, D Paone, J Milliken, CF Turner, H … - Lancet, 1999 - hawaii.edu
... better measurement of risk behaviours will lead to programme improvements, better
control of ... HIV transmission in each ?risky act? may be around 50 ...

Review Article. Intervention research in rational use of drugs: a review -
A Le Grand, V Hogerzeil? - Health Policy and Planning, 1999 - Oxford Univ Press
... Or they may spend money on analgesics to relieve their misery ... is that a limited number
of drugs would lead to a better supply of drugs, better pre- scribing ...

Dendrimers in drug research -
U Boas, PMH Heegaard - Chemical Society Reviews, 2004 - rsc.org
... DNA (3 ?g mL ?1 ), which may lead to apoptosis. ... delivery devices, as the dendrimer
may be degraded ... degraded (or fragmented) dendrimers are better suited for ...

Source: Google Scholar

Research May Lead To Better Drugs To Fight Deadly Pathogens
Biology textbooks suggest that blunt-neutrophils are mindless killers. These white blood cells patrol the body and guard against infection by bacteria and fungi, identifying and destroying any invaders that cross their path. But new evidence, which may lead to better drugs to fight deadly pathogens, indicates that neutrophils might actually distinguish among their targets.

A scientist in the lab of Whitehead Member Gerald Fink has discovered that neutrophils recognize and respond to a specific form of sugar called beta-1,6-glucan on the surface of fungi. This sugar comprises just a small fraction of the fungal cell wall, much less than another sugar with a slightly different chemical conformation called beta-1,3-glucan. Because the scarce form of the sugar elicits a much stronger reaction from immune cells than the abundant one, it appears that neutrophils can distinguish between two nearly identical chemicals.
"These results show that engulfment and killing by neutrophils varies, depending on cell wall properties of the microbe," explains Whitehead postdoctoral researcher Ifat Rubin-Bejerano, first author on the paper, which appears in the journal Cell Host & Microbe. "We showed that neutrophils respond in a completely different way to slight changes in sugar composition. If we are able to use this unique sugar to excite the immune system, it may help the human body fight infection."

"Previously, everyone thought that these key cells of the immune system weren't picky and would eat anything that looked foreign," adds Fink, who is also an MIT professor of biology. "Ifat's work has shown that the cells aren't little Pac-Men, but can discriminate one pathogen from another."

Rubin-Bejerano had evidence that neutrophils respond to beta-glucan. After coating tiny beads with a variety of substances (including beta-1,3-glucan and beta-1,6-glucan), she exposed them to the neutrophils and was surprised to see a striking difference in their response to the two sugars. The neutrophils quickly engulfed many of the beads coated with beta-1,6-glucan, but only a few of those covered in beta-1,3-glucan.

Previous studies indicated that blood serum (basically blood minus cells) helps neutrophils recognize their enemies, so Rubin-Bejerano decided to look for clues to their response in this mixture. She identified several proteins in serum that bind to beta-1,6-glucan, but not beta-1,3-glucan, and then pinpointed a molecule on the surface of the neutrophil that recognizes these proteins.

To link her experiments back to real fungi, Rubin-Bejerano worked with the pathogen Candida albicans, which is the most common fungus in blood stream infections. She used an enzyme to digest beta-1,6-glucan from the fungal cell wall, leaving the beta-1,3-glucan intact. She then unleashed the neutrophils on these altered cells and observed a 50 percent reduction in the immune response.
Our bodies maintain a fine balance between the immune system and microbes. Antibiotics and antifungals tilt the balance in favor of the immune system by targeting the microbes directly. A substance like beta-1,6-glucan could help tilt this balance further by stimulating immune cells.

Rubin-Bejerano's work offers hope for combating the growing problem of microbial infections, which can seriously threaten human health -- particularly in patients with compromised immune systems. In fact, Rubin-Bejerano co-founded a company called ImmuneXcite to explore this possibility.

Source: Alyssa Kneller
Whitehead Institute for Biomedical Research
 
 
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